Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.
McGuire JR, Bester SM, Guelta MA, Cheung J, Langley C, Winemiller MD, Bae SY, Funk V, Myslinski JM, Pegan SD, Height JJ.
McGuire JR, et al.
Chem Res Toxicol. 2021 Mar 15;34(3):804-816. doi: 10.1021/acs.chemrestox.0c00406. Epub 2021 Feb 4.
Chem Res Toxicol. 2021.
PMID: 33538594
To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along with the inhibition kinetics for these agents. ...To identify the structural underpinnings of this phenomenon, the structures of tabun, …
To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along wit …