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2019 10
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Page 1
Neurochemical and Neurobiological Weapons.
Sejvar JJ. Sejvar JJ. Neurol Clin. 2020 Nov;38(4):881-896. doi: 10.1016/j.ncl.2020.07.007. Epub 2020 Sep 12. Neurol Clin. 2020. PMID: 33040867 Review.
Acetylcholinesterase inhibitors act by increasing the amount of acetylcholine in the neuromuscular junction, resulting in flaccid paralysis. Tabun, VX, soman, and sarin are the major agents in this category. ...
Acetylcholinesterase inhibitors act by increasing the amount of acetylcholine in the neuromuscular junction, resulting in flaccid paralysis. …
Nerve agents: emergency preparedness.
Weir AGA, Makin S, Breeze J. Weir AGA, et al. BMJ Mil Health. 2020 Feb;166(1):42-46. doi: 10.1136/jramc-2019-001380. BMJ Mil Health. 2020. PMID: 31999618 Review.
In 1984, Iraq became the first nation to deploy NA on the battlefield when they used tabun against Iranian military forces in Majnoon Island near Basra. ...
In 1984, Iraq became the first nation to deploy NA on the battlefield when they used tabun against Iranian military forces in Majnoon …
Diagnoses of Pathological States Based on Acetylcholinesterase and Butyrylcholinesterase.
Pohanka M. Pohanka M. Curr Med Chem. 2020;27(18):2994-3011. doi: 10.2174/0929867326666190130161202. Curr Med Chem. 2020. PMID: 30706778 Review.
Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, VX, novichok and overdosing by drugs used in some neurodegenerative disorders like Alzheimers disease and myasthenia gravis, as well as poi …
Thus, both AChE and BChE can serve as biochemical markers of various pathologies. Poisoning by nerve agents like sarin, soman, tabun, …
Potential of Vitamin B6 Dioxime Analogues to Act as Cholinesterase Ligands.
Gašo Sokač D, Zandona A, Roca S, Vikić-Topić D, Lihtar G, Maraković N, Bušić V, Kovarik Z, Katalinić M. Gašo Sokač D, et al. Int J Mol Sci. 2022 Nov 2;23(21):13388. doi: 10.3390/ijms232113388. Int J Mol Sci. 2022. PMID: 36362178 Free PMC article.
The second oxime group in the structure did not improve the binding compared to the monooxime analogues. The same was observed for reactivation of VX-, tabun-, and paraoxon-inhibited AChE and BChE, where no significant efficiency burst was noted. ...
The second oxime group in the structure did not improve the binding compared to the monooxime analogues. The same was observed for reactivat …
In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase.
Worek F, Thiermann H, Koller M, Wille T. Worek F, et al. Molecules. 2020 Jul 2;25(13):3029. doi: 10.3390/molecules25133029. Molecules. 2020. PMID: 32630769 Free PMC article.
Defensive research on nerve agents is mainly focused on the "classical five", namely tabun, sarin, soman, cyclosarin and VX, although Schedule 1 of the CWC covers an unforeseeable number of homologues. ...
Defensive research on nerve agents is mainly focused on the "classical five", namely tabun, sarin, soman, cyclosarin and VX, although …
Engineered Recombinant PON1-OPH Fusion Hybrids: Potentially Effective Catalytic Bioscavengers against Organophosphorus Nerve Agent Analogs.
Lee N, Yun H, Lee C, Lee Y, Kim E, Kim S, Jeon H, Yu C, Rho J. Lee N, et al. J Microbiol Biotechnol. 2021 Jan 28;31(1):144-153. doi: 10.4014/jmb.2006.06044. J Microbiol Biotechnol. 2021. PMID: 33144547 Free PMC article.
Organophosphorus nerve agents (OPNAs), including both G- and V-type nerve agents such as sarin, soman, tabun and VX, are extremely neurotoxic organophosphorus compounds. ...
Organophosphorus nerve agents (OPNAs), including both G- and V-type nerve agents such as sarin, soman, tabun and VX, are extremely ne …
Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase.
Čadež T, Kolić D, Šinko G, Kovarik Z. Čadež T, et al. Sci Rep. 2021 Nov 2;11(1):21486. doi: 10.1038/s41598-021-00953-9. Sci Rep. 2021. PMID: 34728713 Free PMC article.
Two newly developed reactivators-bispyridinium triazole oxime 14A and zwitterionic oxime RS194B possess remarkable potential for further development of antidotes directed against pesticides and related phosphoramidate exposures, such as nerve agents tabun or Novichoks....
Two newly developed reactivators-bispyridinium triazole oxime 14A and zwitterionic oxime RS194B possess remarkable potential for further dev …
Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.
McGuire JR, Bester SM, Guelta MA, Cheung J, Langley C, Winemiller MD, Bae SY, Funk V, Myslinski JM, Pegan SD, Height JJ. McGuire JR, et al. Chem Res Toxicol. 2021 Mar 15;34(3):804-816. doi: 10.1021/acs.chemrestox.0c00406. Epub 2021 Feb 4. Chem Res Toxicol. 2021. PMID: 33538594
To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along with the inhibition kinetics for these agents. ...To identify the structural underpinnings of this phenomenon, the structures of tabun, …
To gain insight into this issue, the structures of hAChE inhibited by tabun, sarin, cyclosarin, soman, and GP were obtained along wit …
33 results