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Pharmacoinformatics and molecular docking reveal potential drug candidates against Schizophrenia to target TAAR6.
Tahir RA, Wu H, Javed N, Khalique A, Khan SAF, Mir A, Ahmed MS, Barreto GE, Qing H, Ashraf GM, Sehgal SA. Tahir RA, et al. J Cell Physiol. 2019 Aug;234(8):13263-13276. doi: 10.1002/jcp.27999. Epub 2018 Dec 19. J Cell Physiol. 2019. PMID: 30569503
Schizophrenia (SZ) is a complex disabling disorder that leads to the mental disability and afflicts 1% of the world's total population and placed in top ten medical disorders. ...Absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties, Lipinski rul …
Schizophrenia (SZ) is a complex disabling disorder that leads to the mental disability and afflicts 1% of the world's total populatio …
A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families.
Vladimirov V, Thiselton DL, Kuo PH, McClay J, Fanous A, Wormley B, Vittum J, Ribble R, Moher B, van den Oord E, O'Neill FA, Walsh D, Kendler KS, Riley BP. Vladimirov V, et al. Mol Psychiatry. 2007 Sep;12(9):842-53. doi: 10.1038/sj.mp.4001984. Epub 2007 May 15. Mol Psychiatry. 2007. PMID: 17505468
The TAAR6 gene has been previously associated with schizophrenia in 192 pedigrees of European and African ancestry. To replicate these findings we performed an association study of TAAR6 in 265 pedigrees of the Irish Study of High-Density Schizophrenia …
The TAAR6 gene has been previously associated with schizophrenia in 192 pedigrees of European and African ancestry. To replica …
The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
Vladimirov VI, Maher BS, Wormley B, O'Neill FA, Walsh D, Kendler KS, Riley BP. Vladimirov VI, et al. Schizophr Res. 2009 Feb;107(2-3):249-54. doi: 10.1016/j.schres.2008.09.030. Epub 2008 Oct 30. Schizophr Res. 2009. PMID: 18973992 Free PMC article.
To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Density Schizophrenia Families (ISHDSF) sample, we genotyped 12 single nucleotide polymorphisms (SNPs) in the Irish Case-Control Study of …
To replicate previous association between TAAR6 and schizophrenia, including our own finding in the Irish Study of High Densit …
Association of the trace amine associated receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample.
Pae CU, Yu HS, Amann D, Kim JJ, Lee CU, Lee SJ, Jun TY, Lee C, Paik IH, Patkar AA, Lerer B. Pae CU, et al. J Psychiatr Res. 2008 Jan;42(1):35-40. doi: 10.1016/j.jpsychires.2006.09.011. Epub 2006 Nov 9. J Psychiatr Res. 2008. PMID: 17097106
Previous studies have reported association of the trace amine associated receptor 6 (TAAR6) gene with susceptibility to schizophrenia and bipolar disorder but results have not been consistent. ...The GTT haplotype associations withstand the most rigorous corrections …
Previous studies have reported association of the trace amine associated receptor 6 (TAAR6) gene with susceptibility to schizophre …
No support for an association with TAAR6 and schizophrenia in a linked population of European ancestry.
Ludewick HP, Schwab SG, Albus M, Lerer B, Maier W, Trixler M, Wildenauer DB. Ludewick HP, et al. Psychiatr Genet. 2008 Aug;18(4):208-10. doi: 10.1097/YPG.0b013e3283050aba. Psychiatr Genet. 2008. PMID: 18628684
No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked families (P>0.2). We conclude that trace amine associated receptor 6 is not important for the development of schizophrenia in our famil …
No evidence for association was obtained between these SNPs and schizophrenia in our sample, even when limited to the 56 linked famil …
Trace Amines and Their Receptors.
Gainetdinov RR, Hoener MC, Berry MD. Gainetdinov RR, et al. Pharmacol Rev. 2018 Jul;70(3):549-620. doi: 10.1124/pr.117.015305. Pharmacol Rev. 2018. PMID: 29941461 Review.
Humans possess six functional isoforms (TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9), whereas some fish species express over 100. ...In the brain, TAAR1 acts as a rheostat of dopaminergic, glutamatergic, and serotonergic neurotransmission and has been identified as a nove …
Humans possess six functional isoforms (TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, and TAAR9), whereas some fish species express over 100. .. …
Influence of TAAR6 polymorphisms on response to aripiprazole.
Serretti A, Pae CU, Chiesa A, Mandelli L, De Ronchi D. Serretti A, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2009 Aug 1;33(5):822-6. doi: 10.1016/j.pnpbp.2009.03.032. Epub 2009 Apr 5. Prog Neuropsychopharmacol Biol Psychiatry. 2009. PMID: 19345712
BACKGROUND: There is some evidence suggesting a role of TAAR6 in schizophrenia. The aim of the present study is to investigate possible influences of a panel of markers in TAAR6 (rs8192625, rs4305745, rs4305746, rs6903874, rs6937506) on clinical outcomes and …
BACKGROUND: There is some evidence suggesting a role of TAAR6 in schizophrenia. The aim of the present study is to investigate …
Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.
Pae CU, Drago A, Patkar AA, Jun TY, Serretti A. Pae CU, et al. Eur Neuropsychopharmacol. 2009 Nov;19(11):806-11. doi: 10.1016/j.euroneuro.2009.07.001. Epub 2009 Jul 29. Eur Neuropsychopharmacol. 2009. PMID: 19643584
Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the risk of psychosis and that modifies responses to antipsychotic treatments. Our group previously reported genetic studies on TAAR6 and …
Suggestive associations have been reported between trace amines and heat shock proteins, and a disrupted pathophysiology that enhances the r …
Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association.
Xie Z, Vallender EJ, Yu N, Kirstein SL, Yang H, Bahn ME, Westmoreland SV, Miller GM. Xie Z, et al. J Neurosci Res. 2008 Nov 15;86(15):3435-46. doi: 10.1002/jnr.21783. J Neurosci Res. 2008. PMID: 18627029 Free PMC article.
Several recent studies report an association between trace amine-associated receptor 6 (TAAR6) and susceptibility to schizophrenia and bipolar affective disorder in humans. ...Membrane and cell surface localization of TAAR6 was confirmed by immunocytochemistr …
Several recent studies report an association between trace amine-associated receptor 6 (TAAR6) and susceptibility to schizophrenia …
TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study.
Pae CU, Drago A, Kim JJ, Patkar AA, Jun TY, Lee C, Mandelli L, De Ronchi D, Paik IH, Serretti A. Pae CU, et al. Eur Psychiatry. 2008 Sep;23(6):390-5. doi: 10.1016/j.eurpsy.2008.04.004. Epub 2008 Jun 25. Eur Psychiatry. 2008. PMID: 18583103
We recently reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set of TAAR6 variations and clinical presentation and outcome in a sample of 240 SZ Korean patients …
We recently reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). …
13 results