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1995 1
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92 results

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Page 1
Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.
Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Largo-Barrientos P, et al. Neuron. 2021 Mar 3;109(5):767-777.e5. doi: 10.1016/j.neuron.2020.12.016. Epub 2021 Jan 19. Neuron. 2021. PMID: 33472038 Free PMC article.
We show that heterozygous knockout of synaptogyrin-3 is benign in mice but strongly rescues mutant Tau-induced defects in long-term synaptic plasticity and working memory. ...However, Tau-induced neuroinflammation remains clearly upregulated when we remove the expression o …
We show that heterozygous knockout of synaptogyrin-3 is benign in mice but strongly rescues mutant Tau-induced defects in long-term s …
Phosphatidylserine-dependent structure of synaptogyrin remodels the synaptic vesicle membrane.
Yu T, Flores-Solis D, Eastep GN, Becker S, Zweckstetter M. Yu T, et al. Nat Struct Mol Biol. 2023 Jul;30(7):926-934. doi: 10.1038/s41594-023-01004-9. Epub 2023 May 22. Nat Struct Mol Biol. 2023. PMID: 37217654 Free PMC article.
Using NMR spectroscopy, we determine the high-resolution structure of synaptogyrin and identify specific binding sites for phosphatidylserine. ...Cooperative binding of phosphatidylserine to both a cytoplasmic and intravesicular lysine-arginine cluster in synaptogyrin …
Using NMR spectroscopy, we determine the high-resolution structure of synaptogyrin and identify specific binding sites for phosphatid …
Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.
McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. McInnes J, et al. Neuron. 2018 Feb 21;97(4):823-835.e8. doi: 10.1016/j.neuron.2018.01.022. Epub 2018 Feb 1. Neuron. 2018. PMID: 29398363 Free article.
We define that the binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3. In fly and mouse models of Tauopathy, reduction of Synaptogyrin-3 prevents the association of presynaptic Tau with vesicles, alleviates Tau-induce …
We define that the binding of Tau to synaptic vesicles is mediated by the transmembrane vesicle protein Synaptogyrin-3. In fly and mo …
Synaptogyrin-2 influences replication of Porcine circovirus 2.
Walker LR, Engle TB, Vu H, Tosky ER, Nonneman DJ, Smith TPL, Borza T, Burkey TE, Plastow GS, Kachman SD, Ciobanu DC. Walker LR, et al. PLoS Genet. 2018 Oct 31;14(10):e1007750. doi: 10.1371/journal.pgen.1007750. eCollection 2018 Oct. PLoS Genet. 2018. PMID: 30379811 Free PMC article.
Synaptogyrin-dependent modulation of synaptic neurotransmission in Caenorhabditis elegans.
Abraham C, Bai L, Leube RE. Abraham C, et al. Neuroscience. 2011 Sep 8;190:75-88. doi: 10.1016/j.neuroscience.2011.05.069. Epub 2011 Jun 13. Neuroscience. 2011. PMID: 21689733
Employing fluorescent reporter constructs we find that synaptogyrin is expressed in all GABAergic neurons and most, though not all other neurons. ...Taken together, these observations assign a distinct modulatory and redundant neuronal function to synaptogyrin....
Employing fluorescent reporter constructs we find that synaptogyrin is expressed in all GABAergic neurons and most, though not all ot …
Synaptogyrin-2 Promotes Replication of a Novel Tick-borne Bunyavirus through Interacting with Viral Nonstructural Protein NSs.
Sun Q, Qi X, Zhang Y, Wu X, Liang M, Li C, Li D, Cardona CJ, Xing Z. Sun Q, et al. J Biol Chem. 2016 Jul 29;291(31):16138-49. doi: 10.1074/jbc.M116.715599. Epub 2016 May 16. J Biol Chem. 2016. PMID: 27226560 Free PMC article.
Synaptogyrin-2 is a non-neuronal member of the synaptogyrin family involved in synaptic vesicle biogenesis and trafficking. ...These findings unveil the function of synaptogyrin-2 as an enhancer in viral infection....
Synaptogyrin-2 is a non-neuronal member of the synaptogyrin family involved in synaptic vesicle biogenesis and trafficking. .. …
SYNGR2 serves as a prognostic biomarker and correlates with immune infiltrates in esophageal squamous cell carcinoma.
Li B, Ren MY, Chen YZ, Meng YQ, Song TN, Su ZP, Yang B. Li B, et al. J Gene Med. 2022 Aug;24(8):e3441. doi: 10.1002/jgm.3441. Epub 2022 Aug 1. J Gene Med. 2022. PMID: 35840542
BACKGROUND: Synaptogyrin-2 (SYNGR2) plays an important role in regulating membrane traffic in non-neuronal cells. ...
BACKGROUND: Synaptogyrin-2 (SYNGR2) plays an important role in regulating membrane traffic in non-neuronal cells. ...
Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer.
Murphy RM, Tasoulas J, Porrello A, Carper MB, Tsai YH, Coffey AR, Kumar S, Zeng PY, Schrank TP, Midkiff BR, Cohen S, Salazar AH, Hayward MC, Hayes DN, Olshan A, Gupta GP, Nichols AC, Yarbrough WG, Pecot CV, Amelio AL. Murphy RM, et al. Cancer Res Commun. 2022 Sep;2(9):987-1004. doi: 10.1158/2767-9764.crc-21-0135. Epub 2022 Sep 15. Cancer Res Commun. 2022. PMID: 36148399 Free PMC article.
We performed multiplex immunofluorescent staining to confirm expression within the immune cells of HPV(+) tumors, receiver operating characteristic (ROC) curve analyses, and assessed survival outcomes. The neuronal gene Synaptogyrin-3 (SYNGR3) is robustly expressed in immu …
We performed multiplex immunofluorescent staining to confirm expression within the immune cells of HPV(+) tumors, receiver operating charact …
Characterization of synaptogyrin 3 as a new synaptic vesicle protein.
Belizaire R, Komanduri C, Wooten K, Chen M, Thaller C, Janz R. Belizaire R, et al. J Comp Neurol. 2004 Mar 8;470(3):266-81. doi: 10.1002/cne.20008. J Comp Neurol. 2004. PMID: 14755516
Subcellular fractionation and immunoprecipitation of synaptic vesicles from mouse brain showed that synaptogyrin 3 is associated with synaptic vesicles and that synaptogyrins 1 and 3 can reside on the same synaptic vesicle. Immunofluorescent staining of cultured hip …
Subcellular fractionation and immunoprecipitation of synaptic vesicles from mouse brain showed that synaptogyrin 3 is associated with …
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.
Stenius K, Janz R, Südhof TC, Jahn R. Stenius K, et al. J Cell Biol. 1995 Dec;131(6 Pt 2):1801-9. doi: 10.1083/jcb.131.6.1801. J Cell Biol. 1995. PMID: 8557746 Free PMC article.
Synaptogyrin (p29) is a synaptic vesicle protein that is uniformly distributed in the nervous system (Baumert et al., 1990). ...Database searches revealed several cDNA sequences coding polypeptides with sequence identities ranging from 32 to 46%, suggesting that synapto …
Synaptogyrin (p29) is a synaptic vesicle protein that is uniformly distributed in the nervous system (Baumert et al., 1990). ...Datab …
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