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Results: 1 to 20 of 67


Heterozygosity for a hypomorphic polβ mutation reduces the expansion frequency in a mouse model of the fragile x-related disorders.

Lokanga RA, Senejani AG, Sweasy JB, Usdin K.

PLoS Genet. 2015 Apr 17;11(4):e1005181. doi: 10.1371/journal.pgen.1005181. eCollection 2015 Apr.


Tumor-associated mutations in a conserved structural motif alter physical and biochemical properties of human RAD51 recombinase.

Chen J, Morrical MD, Donigan KA, Weidhaas JB, Sweasy JB, Averill AM, Tomczak JA, Morrical SW.

Nucleic Acids Res. 2015 Jan;43(2):1098-111. doi: 10.1093/nar/gku1337. Epub 2014 Dec 24.


A germline polymorphism of thymine DNA glycosylase induces genomic instability and cellular transformation.

Sjolund A, Nemec AA, Paquet N, Prakash A, Sung P, Doublié S, Sweasy JB.

PLoS Genet. 2014 Nov 6;10(11):e1004753. doi: 10.1371/journal.pgen.1004753. eCollection 2014 Nov.


Fluorescence resonance energy transfer studies of DNA polymerase β: the critical role of fingers domain movements and a novel non-covalent step during nucleotide selection.

Towle-Weicksel JB, Dalal S, Sohl CD, Doublié S, Anderson KS, Sweasy JB.

J Biol Chem. 2014 Jun 6;289(23):16541-50. doi: 10.1074/jbc.M114.561878. Epub 2014 Apr 24.


The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.

Nemec AA, Murphy DL, Donigan KA, Sweasy JB.

J Biol Chem. 2014 May 16;289(20):13708-16. doi: 10.1074/jbc.M114.550400. Epub 2014 Mar 25.



Sweasy JB, Glazer PM.

Yale J Biol Med. 2013 Dec;86(4):441-2. No abstract available.


Mutation of POLB causes lupus in mice.

Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB.

Cell Rep. 2014 Jan 16;6(1):1-8. doi: 10.1016/j.celrep.2013.12.017. Epub 2014 Jan 2.


Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: activity, structure, and the effect of editing.

Prakash A, Carroll BL, Sweasy JB, Wallace SS, Doublié S.

DNA Repair (Amst). 2014 Feb;14:17-26. doi: 10.1016/j.dnarep.2013.12.003. Epub 2013 Dec 29.


Cellular roles of DNA polymerase beta.

Ray S, Menezes MR, Senejani A, Sweasy JB.

Yale J Biol Med. 2013 Dec 13;86(4):463-9. Review.


Kinesin 5B (KIF5B) is required for progression through female meiosis and proper chromosomal segregation in mitotic cells.

Kidane D, Sakkas D, Nottoli T, McGrath J, Sweasy JB.

PLoS One. 2013;8(4):e58585. doi: 10.1371/journal.pone.0058585. Epub 2013 Apr 1.


MBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological roles.

Sjolund AB, Senejani AG, Sweasy JB.

Mutat Res. 2013 Mar-Apr;743-744:12-25. doi: 10.1016/j.mrfmmm.2012.11.001. Epub 2012 Nov 26. Review.


A germline polymorphism of DNA polymerase beta induces genomic instability and cellular transformation.

Yamtich J, Nemec AA, Keh A, Sweasy JB.

PLoS Genet. 2012;8(11):e1003052. doi: 10.1371/journal.pgen.1003052. Epub 2012 Nov 8.


Targeting cancer with a lupus autoantibody.

Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, Rockwell S, Nishimura RN, Weisbart RH, Glazer PM.

Sci Transl Med. 2012 Oct 24;4(157):157ra142. doi: 10.1126/scitranslmed.3004385.


Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.

Lamb KL, Liu Y, Ishiguro K, Kwon Y, Paquet N, Sartorelli AC, Sung P, Rockwell S, Sweasy JB.

Mol Carcinog. 2014 Mar;53(3):201-10. doi: 10.1002/mc.21964. Epub 2012 Oct 12.


The cell pole: the site of cross talk between the DNA uptake and genetic recombination machinery.

Kidane D, Ayora S, Sweasy JB, Graumann PL, Alonso JC.

Crit Rev Biochem Mol Biol. 2012 Nov-Dec;47(6):531-55. doi: 10.3109/10409238.2012.729562. Epub 2012 Oct 9. Review.


Mouse models of DNA polymerases.

Menezes MR, Sweasy JB.

Environ Mol Mutagen. 2012 Dec;53(9):645-65. doi: 10.1002/em.21731. Epub 2012 Sep 22. Review.


DNA polymerase β variant Ile260Met generates global gene expression changes related to cellular transformation.

Donigan KA, Tuck D, Schulz V, Sweasy JB.

Mutagenesis. 2012 Nov;27(6):683-91. doi: 10.1093/mutage/ges034. Epub 2012 Aug 21.


Tipping the balance in the powerhouse of the cell to "protect" colorectal cancer.

Kidane D, Sweasy JB.

PLoS Genet. 2012;8(6):e1002758. doi: 10.1371/journal.pgen.1002758. Epub 2012 Jun 7. No abstract available.


The E288K colon tumor variant of DNA polymerase β is a sequence specific mutator.

Murphy DL, Donigan KA, Jaeger J, Sweasy JB.

Biochemistry. 2012 Jul 3;51(26):5269-75. Epub 2012 Jun 19.

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