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The following term was not found in PubMed: succinonitrite
Page 1
Succinylation Links Metabolism to Protein Functions.
Yang Y, Gibson GE. Yang Y, et al. Neurochem Res. 2019 Oct;44(10):2346-2359. doi: 10.1007/s11064-019-02780-x. Epub 2019 Mar 22. Neurochem Res. 2019. PMID: 30903449 Free PMC article. Review.
Phosphorylation and acetylation are particularly well studied PTMs. A relatively recently discovered novel PTM is succinylation in which metabolically derived succinyl CoA modifies protein lysine groups. ...This review provides a new insight into metabolism in neuro …
Phosphorylation and acetylation are particularly well studied PTMs. A relatively recently discovered novel PTM is succinylation in wh …
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R, Lu Z. Tong Y, et al. Mol Cell. 2021 Jun 3;81(11):2303-2316.e8. doi: 10.1016/j.molcel.2021.04.002. Epub 2021 May 14. Mol Cell. 2021. PMID: 33991485 Free article.
Here, we demonstrate that kidney-type glutaminase (GLS) is highly expressed in human pancreatic ductal adenocarcinoma (PDAC) specimens with correspondingly upregulated glutamine dependence for PDAC cell proliferation. Upon oxidative stress, the succinyl-coenzyme A (CoA) sy …
Here, we demonstrate that kidney-type glutaminase (GLS) is highly expressed in human pancreatic ductal adenocarcinoma (PDAC) specimens with …
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Park J, et al. Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001. Mol Cell. 2013. PMID: 23806337 Free PMC article.
We report systematic profiling of the mammalian succinylome, identifying 2,565 succinylation sites on 779 proteins. Most of these do not overlap with acetylation sites, suggesting differential regulation of succinylation and acetylation. ...Lysine succinylation …
We report systematic profiling of the mammalian succinylome, identifying 2,565 succinylation sites on 779 proteins. Most of these do …
SUCLG2 Regulates Mitochondrial Dysfunction through Succinylation in Lung Adenocarcinoma.
Hu Q, Xu J, Wang L, Yuan Y, Luo R, Gan M, Wang K, Zhao T, Wang Y, Han T, Wang JB. Hu Q, et al. Adv Sci (Weinh). 2023 Dec;10(35):e2303535. doi: 10.1002/advs.202303535. Epub 2023 Oct 30. Adv Sci (Weinh). 2023. PMID: 37904651 Free PMC article.
However, the mechanisms underlying mitochondrial dysfunction during cancer progression are far from being clarified. Here, it is demonstrated that the expression level of succinyl-coenzyme A (CoA) synthetase GDP-forming subunit beta (SUCLG2) can affect the overall succi …
However, the mechanisms underlying mitochondrial dysfunction during cancer progression are far from being clarified. Here, it is demonstrate …
Identification of lysine succinylation as a new post-translational modification.
Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y. Zhang Z, et al. Nat Chem Biol. 2011 Jan;7(1):58-63. doi: 10.1038/nchembio.495. Epub 2010 Dec 12. Nat Chem Biol. 2011. PMID: 21151122 Free PMC article.
Here we report the identification and verification of a previously unreported form of protein post-translational modification (PTM): lysine succinylation. The succinyllysine residue was initially identified by mass spectrometry and protein sequence alignment. ...Our study …
Here we report the identification and verification of a previously unreported form of protein post-translational modification (PTM): lysine …
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. Rardin MJ, et al. Cell Metab. 2013 Dec 3;18(6):920-33. doi: 10.1016/j.cmet.2013.11.013. Cell Metab. 2013. PMID: 24315375 Free PMC article.
Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased beta-hydroxybutyrate production in vivo. In addition, we demonstrate that SIRT5 regulates succinylation of the rate-limiting ketogenic enzyme 3-hydroxy-3-methylglutaryl-CoA synthase …
Loss of SIRT5 leads to accumulation of medium- and long-chain acylcarnitines and decreased beta-hydroxybutyrate production in vivo. In addit …
Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation.
Wang G, Meyer JG, Cai W, Softic S, Li ME, Verdin E, Newgard C, Schilling B, Kahn CR. Wang G, et al. Mol Cell. 2019 May 16;74(4):844-857.e7. doi: 10.1016/j.molcel.2019.03.021. Epub 2019 Apr 15. Mol Cell. 2019. PMID: 31000437 Free PMC article.
BAT-specific deletion of Sirt5, a mitochondrial desuccinylase and demalonylase, results in dramatic increases in global protein succinylation and malonylation. Mass spectrometry-based quantification of succinylation reveals that Sirt5 regulates the key thermogenic p …
BAT-specific deletion of Sirt5, a mitochondrial desuccinylase and demalonylase, results in dramatic increases in global protein succinyla …
Sirtuin 5-Mediated Lysine Desuccinylation Protects Mitochondrial Metabolism Following Subarachnoid Hemorrhage in Mice.
Xiao ZP, Lv T, Hou PP, Manaenko A, Liu Y, Jin Y, Gao L, Jia F, Tian Y, Li P, Zhang JH, Hu Q, Zhang X. Xiao ZP, et al. Stroke. 2021 Dec;52(12):4043-4053. doi: 10.1161/STROKEAHA.121.034850. Epub 2021 Nov 22. Stroke. 2021. PMID: 34807744
The endovascular perforation SAH model was applied. Protein lysine succinylation in the brain cortex was examined using liquid chromatography-tandem mass spectrometry analysis. ...Thirty-nine percent of these succinylated proteins were localized in mitochondria and …
The endovascular perforation SAH model was applied. Protein lysine succinylation in the brain cortex was examined using liquid chroma …
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. Wang Y, et al. Nature. 2017 Dec 14;552(7684):273-277. doi: 10.1038/nature25003. Epub 2017 Dec 6. Nature. 2017. PMID: 29211711 Free PMC article.
We show that succinyl-coenzyme A (succinyl-CoA) binds to KAT2A. The crystal structure of the catalytic domain of KAT2A in complex with succinyl-CoA at 2.3 A resolution shows that succinyl-CoA binds to a deep cleft of KAT2A with the succinyl moie …
We show that succinyl-coenzyme A (succinyl-CoA) binds to KAT2A. The crystal structure of the catalytic domain of KAT2A in comp …
Succinylation Inhibits the Enzymatic Hydrolysis of the Extracellular Matrix Protein Fibrillin 1 and Promotes Gastric Cancer Progression.
Wang X, Shi X, Lu H, Zhang C, Li X, Zhang T, Shen J, Wen J. Wang X, et al. Adv Sci (Weinh). 2022 Sep;9(27):e2200546. doi: 10.1002/advs.202200546. Epub 2022 Jul 28. Adv Sci (Weinh). 2022. PMID: 35901491 Free PMC article.
In 3D matrix culture and animal models, it is found that fibrillin 1 (FBN1) expression is increased in advanced GC and has succinylation modification. The succinylation modification of FBN1 blocks its degradation by matrix metalloproteinases (MMPs). ...In conclusion …
In 3D matrix culture and animal models, it is found that fibrillin 1 (FBN1) expression is increased in advanced GC and has succinylation …
6,125 results