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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1978 2
1979 3
1980 3
1981 3
1982 4
1983 9
1984 9
1985 12
1986 16
1987 16
1988 15
1989 21
1990 34
1991 40
1992 35
1993 40
1994 46
1995 55
1996 47
1997 46
1998 43
1999 41
2000 40
2001 41
2002 31
2003 38
2004 51
2005 48
2006 55
2007 86
2008 93
2009 101
2010 109
2011 140
2012 148
2013 169
2014 162
2015 147
2016 177
2017 185
2018 177
2019 167
2020 188
2021 160
2022 78
2023 84
2024 63

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Search Results

2,897 results

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Page 1
The Discovery and Function of Filaggrin.
Hoober JK, Eggink LL. Hoober JK, et al. Int J Mol Sci. 2022 Jan 27;23(3):1455. doi: 10.3390/ijms23031455. Int J Mol Sci. 2022. PMID: 35163390 Free PMC article. Review.
The first indications of the composition of these structures emerged in the 1960s from a histochemical stain for histidine, followed by radioautographic evidence of a high incidence of histidine incorporation into newly synthesized proteins in cells containing the granules …
The first indications of the composition of these structures emerged in the 1960s from a histochemical stain for histidine, followed by radi …
Endotypes of atopic dermatitis and food allergy.
Hui-Beckman JW, Goleva E, Berdyshev E, Leung DYM. Hui-Beckman JW, et al. J Allergy Clin Immunol. 2023 Jan;151(1):26-28. doi: 10.1016/j.jaci.2022.07.021. Epub 2022 Aug 30. J Allergy Clin Immunol. 2023. PMID: 36050129 Review.
Epithelial barrier dysfunction is important in both conditions. Genetic factors, such as filaggrin mutations and IL-4 receptor alpha chain polymorphisms, are linked to increased risk. ...Comprehensive multiomic studies using skin tape stripping have identified distinct ato …
Epithelial barrier dysfunction is important in both conditions. Genetic factors, such as filaggrin mutations and IL-4 receptor alpha …
Moisturization and skin barrier function.
Rawlings AV, Harding CR. Rawlings AV, et al. Dermatol Ther. 2004;17 Suppl 1:43-8. doi: 10.1111/j.1396-0296.2004.04s1005.x. Dermatol Ther. 2004. PMID: 14728698 Review.
Over the past decade, great progress has been made toward elucidating the structure and function of the stratum corneum (SC), the outermost layer of the epidermis. SC cells (corneocytes) protect against desiccation and environmental challenge by regulating water flu …
Over the past decade, great progress has been made toward elucidating the structure and function of the stratum corneum (SC), …
The skin: an indispensable barrier.
Proksch E, Brandner JM, Jensen JM. Proksch E, et al. Exp Dermatol. 2008 Dec;17(12):1063-72. doi: 10.1111/j.1600-0625.2008.00786.x. Exp Dermatol. 2008. PMID: 19043850 Review.
In this review we provide an overview of several components of the physical barrier, explaining how barrier function is regulated and altered in dermatoses. The physical barrier is mainly localized in the stratum corneum (SC) and consists of protein-enriched …
In this review we provide an overview of several components of the physical barrier, explaining how barrier function is regulated and altere …
Particulate matter causes skin barrier dysfunction.
Kim BE, Kim J, Goleva E, Berdyshev E, Lee J, Vang KA, Lee UH, Han S, Leung S, Hall CF, Kim NR, Bronova I, Lee EJ, Yang HR, Leung DY, Ahn K. Kim BE, et al. JCI Insight. 2021 Mar 8;6(5):e145185. doi: 10.1172/jci.insight.145185. JCI Insight. 2021. PMID: 33497363 Free PMC article.
The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In this study, the effects of PM2.5 on filaggrin (FLG) and skin barrier function were investigated in vitro and in vivo. ...Experimenta …
The molecular mechanisms that underlie the detrimental effects of particulate matter (PM) on skin barrier function are poorly understood. In …
Advances and novel developments in mechanisms of allergic inflammation.
Han X, Krempski JW, Nadeau K. Han X, et al. Allergy. 2020 Dec;75(12):3100-3111. doi: 10.1111/all.14632. Epub 2020 Nov 4. Allergy. 2020. PMID: 33068299 Review.
In this review, we discuss several significant recent developments in basic and clinical research as well as important future research directions in allergic inflammation. ...We have seen how mutations in the filaggrin gene are a significant risk factor for allergic …
In this review, we discuss several significant recent developments in basic and clinical research as well as important future researc …
Similarities between stratum corneum basic protein and histidine-rich protein II from newborn rat epidermis.
Dale BA, Vadlamudi B, DeLap LW, Bernstein IA. Dale BA, et al. Biochim Biophys Acta. 1981 Mar 27;668(1):98-106. doi: 10.1016/0005-2795(81)90153-7. Biochim Biophys Acta. 1981. PMID: 6165394 Free article.
The stratum corneum basic protein and histidine-rich protein II were each isolated from newborn rat epidermis and compared by biochemical and immunologic methods. ...Both proteins aggregate with keratin filaments to form macrofibrils. The …
The stratum corneum basic protein and histidine-rich protein II were each isolated from newborn rat epide …
Pathobiology of the stratum corneum.
Jackson SM, Williams ML, Feingold KR, Elias PM. Jackson SM, et al. West J Med. 1993 Mar;158(3):279-85. West J Med. 1993. PMID: 8460510 Free PMC article. Review.
The epidermis is a dynamic system whose metabolic activity is regulated in large part by the integrity of the permeability barrier. This barrier resides in the stratum corneum and comprises a unique 2-compartment system of structural protein-enriched corneocy …
The epidermis is a dynamic system whose metabolic activity is regulated in large part by the integrity of the permeability barrier. This bar …
Stratum corneum basic protein: an interfilamentous matrix protein of epidermal keratin.
Dale BA, Lonsdale-Eccles JD, Holbrook KA. Dale BA, et al. Curr Probl Dermatol. 1980;10:311-25. doi: 10.1159/000396298. Curr Probl Dermatol. 1980. PMID: 6165525
The stratum corneum basic protein (SCBP) aggregates specifically with keratin filaments, forming macrofibrils in which the filaments are highly aligned. The appearance of the macrofibrils formed in vitro is similar to the keratin pattern in the intact …
The stratum corneum basic protein (SCBP) aggregates specifically with keratin filaments, forming macrofibrils in …
2,897 results