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Showing results for stereocenter
Your search for spermocenter retrieved no results
From Three- to Six-Membered Heterocycles Bearing a Quaternary Stereocenter: an Asymmetric Organocatalytic Approach.
Lattanzi A. Lattanzi A. Chem Rec. 2023 May;23(5):e202300066. doi: 10.1002/tcr.202300066. Epub 2023 Apr 12. Chem Rec. 2023. PMID: 37042434 Review.
The development of procedures useful to form quaternary stereocenters stands out as a highly challenging task in asymmetric synthesis. ...In this account, our achievements, spanning over a decade, on asymmetric methodologies to access novel three-, five-, six-membered hete …
The development of procedures useful to form quaternary stereocenters stands out as a highly challenging task in asymmetric synthesis …
Stereochemical Editing.
Tan G, Glorius F. Tan G, et al. Angew Chem Int Ed Engl. 2023 Mar 6;62(11):e202217840. doi: 10.1002/anie.202217840. Epub 2023 Jan 16. Angew Chem Int Ed Engl. 2023. PMID: 36576752 Review.
Stereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adjust their relative stereochemistry at a late-stage. ...
Stereochemical editing has recently risen to prominence, allowing the direct editing of organic molecules with stereocenter(s) to adj …
Remote Stereocenter through Amide-Directed, Rhodium-Catalyzed Enantioselective Hydroboration of Unactivated Internal Alkenes.
Zhao W, Chen KZ, Li AZ, Li BJ. Zhao W, et al. J Am Chem Soc. 2022 Jul 27;144(29):13071-13078. doi: 10.1021/jacs.2c05993. Epub 2022 Jul 13. J Am Chem Soc. 2022. PMID: 35830595
Despite the frequent occurrence of gamma-branched amines in bioactive molecules, the direct catalytic asymmetric synthesis of this structural motif containing a remote stereocenter remains an important synthetic challenge. Here, we report an amide-directed, rhodium-catalyz …
Despite the frequent occurrence of gamma-branched amines in bioactive molecules, the direct catalytic asymmetric synthesis of this structura …
Catalytic Enantioselective Entry to Triflones Featuring a Quaternary Stereocenter.
Franco F, Meninno S, Overgaard J, Rossi S, Benaglia M, Lattanzi A. Franco F, et al. Org Lett. 2022 Jun 24;24(24):4371-4376. doi: 10.1021/acs.orglett.2c01589. Epub 2022 Jun 10. Org Lett. 2022. PMID: 35687515 Free PMC article.
A highly enantioselective one-pot synthesis of functionalized triflones, bearing a quaternary stereocenter, has been developed, exploiting the Michael reaction of alpha-(trifluoromethylsulfonyl) aryl acetic acid esters with N-acryloyl-1H-pyrazole catalyzed by commercially …
A highly enantioselective one-pot synthesis of functionalized triflones, bearing a quaternary stereocenter, has been developed, explo …
Catalytic Asymmetric Synthesis of Troger's Base Analogues with Nitrogen Stereocenter.
Ma C, Sun Y, Yang J, Guo H, Zhang J. Ma C, et al. ACS Cent Sci. 2023 Jan 4;9(1):64-71. doi: 10.1021/acscentsci.2c01121. eCollection 2023 Jan 25. ACS Cent Sci. 2023. PMID: 36712492 Free PMC article.
Nitrogen stereocenters are common chiral units in natural products, pharmaceuticals, and chiral catalysts. However, their research has lagged largely behind, compared with carbon stereocenters and other heteroatom stereocenters. Herein, we report an efficient …
Nitrogen stereocenters are common chiral units in natural products, pharmaceuticals, and chiral catalysts. However, their research ha …
General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.
Zhang Z , Cepeda AJ , Robles ML , Hirsch M , Kumru K , Zhou JA , Keatinge-Clay AT . Zhang Z , et al. Chem Commun (Camb). 2019 Dec 17;56(1):157-160. doi: 10.1039/c9cc07966a. Chem Commun (Camb). 2019. PMID: 31799975 Free PMC article.
Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities....
Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers wa …
Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine.
Niki A, Ozeki M, Kuse A, Nakagawa S, Aoki S, Shigeta T, Kajimoto T, Iwasaki H, Kojima N, Arimitsu K, Hosoi S, Node M, Yamashita M, Kawasaki I. Niki A, et al. Chem Pharm Bull (Tokyo). 2021;69(9):926-930. doi: 10.1248/cpb.c21-00436. Chem Pharm Bull (Tokyo). 2021. PMID: 34470957 Free article.
Acyclic asymmetric quaternary stereocenters, which are composed of four carbon-carbon bonds, were finely constructed by utilizing a face-selective alkylation of enolate intermediates derived from an asymmetric Michael addition reaction of a chiral lithium amide with trisub …
Acyclic asymmetric quaternary stereocenters, which are composed of four carbon-carbon bonds, were finely constructed by utilizing a f …
Dinuclear Zinc-Catalyzed Asymmetric Desymmetrization of Cyclopentendiones: Access to Functional Cyclopentanediones Bearing an All-carbon Quaternary Stereocenter.
Du SS, Zhai YH, Zhang C, Wang MC, Jia SK, Mei GJ, Hua YZ. Du SS, et al. Chem Asian J. 2023 Sep 15;18(18):e202300591. doi: 10.1002/asia.202300591. Epub 2023 Aug 9. Chem Asian J. 2023. PMID: 37524655
Under mild conditions, a series of functional cyclopentanediones bearing multiple stereogenic centers including an all-carbon quaternary stereocenter, were obtained in moderate to good yields with excellent stereoselectivities....
Under mild conditions, a series of functional cyclopentanediones bearing multiple stereogenic centers including an all-carbon quaternary …
Synthesis of pyranopyrazoles with a chiral quaternary carbon stereocenter via copper-catalyzed enantioselective [3 + 3] cycloaddition.
Wang M, Li B, Gong B, Yao H, Lin A. Wang M, et al. Chem Commun (Camb). 2022 Feb 24;58(17):2850-2853. doi: 10.1039/d1cc07058d. Chem Commun (Camb). 2022. PMID: 35129569
This reaction provided an efficient route to synthesize pyranopyrazoles containing a chiral quaternary carbon stereocenter in good yields with good to excellent enantioselectivities. ...
This reaction provided an efficient route to synthesize pyranopyrazoles containing a chiral quaternary carbon stereocenter in good yi …
N-Heterocyclic carbene catalyzed desymmetrization of diols: access to enantioenriched oxindoles having a C3-quaternary stereocenter.
Dutta S, Porey A, Guin J. Dutta S, et al. Chem Commun (Camb). 2023 May 9;59(38):5771-5774. doi: 10.1039/d3cc00489a. Chem Commun (Camb). 2023. PMID: 37096372
Herein, we describe an effective strategy for enantioselective synthesis of oxindoles having a C3-quaternary stereocenter via N-heterocyclic carbene (NHC) catalyzed desymmetrization of diols. ...
Herein, we describe an effective strategy for enantioselective synthesis of oxindoles having a C3-quaternary stereocenter via N-heter …
4,140 results