Genetic and environmental influences on insomnia, daytime sleepiness, and obesity in twins

Sleep. 2006 May;29(5):645-9. doi: 10.1093/sleep/29.5.645.

Abstract

Study objectives: To better understand the relationships of insomnia, sleepiness, and obesity.

Design: Classic twin study.

Setting: A community-based twin registry in Washington State.

Patients or participants: One thousand forty-two monozygotic and 828 dizygotic twin pairs participating in the University of Washington Twin Registry.

Interventions: N/A.

Measurements and results: Twins were, on average, 32 years old; 61% were women, and 19.5% were obese, defined as a body mass index > or = 28. Insomnia and sleepiness were endorsed by 19.3% and 3.7% of twins, respectively. Twin correlations were higher in monozygotic than dizygotic twins for insomnia (0.47 versus 0.15), sleepiness (0.37 versus 0.14), and obesity (0.82 versus 0.46). Heritability estimates were 57% for insomnia (p < .001; 95% confidence interval 47-63), 38% for sleepiness (p < .01; 95% confidence interval 16-46), and 73% for obesity (p < .001; 95% confidence interval 49-87). Multivariate genetic model fitting revealed that common additive genetic effects comprised 12.8% of the phenotypic correlation between insomnia and sleepiness (p < .01) and 10% of the phenotypic correlation between insomnia and obesity (p < .01). The phenotypic correlation between sleepiness and obesity was not due to common additive genetic effects.

Conclusions: Insomnia, sleepiness, and obesity are under strong genetic influence. Common genetic effects were observed between insomnia and both sleepiness and obesity, suggesting shared genetic contributions to these phenomena.

Publication types

  • Twin Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Circadian Rhythm*
  • Disorders of Excessive Somnolence / epidemiology*
  • Environment*
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Middle Aged
  • Obesity / epidemiology*
  • Phenotype
  • Registries
  • Sleep Initiation and Maintenance Disorders / epidemiology*
  • Sleep Initiation and Maintenance Disorders / genetics*
  • Sleep, REM / physiology
  • Twins / genetics*