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2001 1
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2007 1
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2010 2
2012 2
2013 3
2014 6
2015 4
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2017 2
2018 4
2019 5
2020 1
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Page 1
Common variants in SLC1A2 and schizophrenia: Association and cognitive function in patients with schizophrenia and healthy individuals.
Zhang B, Guan F, Chen G, Lin H, Zhang T, Feng J, Li L, Fu D. Zhang B, et al. Schizophr Res. 2015 Dec;169(1-3):128-134. doi: 10.1016/j.schres.2015.10.012. Epub 2015 Oct 12. Schizophr Res. 2015. PMID: 26459047
SLC1A2 is reported to be responsible for the majority of glutamate uptake, which has a crucial role in neural development and synaptic plasticity, and a disturbance in glutamatergic transmission has been suggested to be involved in the pathophysiology of schizophrenia …
SLC1A2 is reported to be responsible for the majority of glutamate uptake, which has a crucial role in neural development and synapti …
No genetic association between the SLC1A2 gene and Japanese patients with schizophrenia.
Nagai Y, Ohnuma T, Karibe J, Shibata N, Maeshima H, Baba H, Hatano T, Hanzawa R, Arai H. Nagai Y, et al. Neurosci Lett. 2009 Oct 9;463(3):223-7. doi: 10.1016/j.neulet.2009.07.092. Epub 2009 Aug 4. Neurosci Lett. 2009. PMID: 19660525
Among these, EAAT2 (also known as solute carrier family 1, member 2; SLC1A2) has been widely studied in schizophrenia pathophysiology. During the last decade, we reported significant decreases in EAAT2 mRNA expression in the prefrontal cortex and parahippocampal gyr …
Among these, EAAT2 (also known as solute carrier family 1, member 2; SLC1A2) has been widely studied in schizophrenia pathophy …
Association study of polymorphisms in the excitatory amino acid transporter 2 gene (SLC1A2) with schizophrenia.
Deng X, Shibata H, Ninomiya H, Tashiro N, Iwata N, Ozaki N, Fukumaki Y. Deng X, et al. BMC Psychiatry. 2004 Aug 6;4:21. doi: 10.1186/1471-244X-4-21. BMC Psychiatry. 2004. PMID: 15296513 Free PMC article.
We have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. In this study we report an association study of the excitatory amino acid transporter 2 gene, SLC1A2 with schizophrenia. ...CONCLUSION: …
We have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. In this st …
Molecular mechanisms of schizophrenia.
Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, Gallinat J. Lang UE, et al. Cell Physiol Biochem. 2007;20(6):687-702. doi: 10.1159/000110430. Cell Physiol Biochem. 2007. PMID: 17982252 Free article. Review.
The most widely considered neurodevelopmental hypothesis of schizophrenia integrates environmental influences and causative genes. ...The glutamatergic hypothesis of schizophrenia lead recently to a first successful mGlu2/3 receptor agonistic drug and is underpinned …
The most widely considered neurodevelopmental hypothesis of schizophrenia integrates environmental influences and causative genes. .. …
Association of rare variation in the glutamate receptor gene SLC1A2 with susceptibility to bipolar disorder and schizophrenia.
Fiorentino A, Sharp SI, McQuillin A. Fiorentino A, et al. Eur J Hum Genet. 2015 Sep;23(9):1200-6. doi: 10.1038/ejhg.2014.261. Epub 2014 Nov 19. Eur J Hum Genet. 2015. PMID: 25406999 Free PMC article.
The SLC1A2 gene encodes the excitatory amino acid transporter 2 (EAAT2). Glutamate is the major mediator of excitatory neurotransmission and EAAT2 is responsible for clearing the neurotransmitter from the synaptic cleft. Genetic variation in SLC1A2 has been implicat …
The SLC1A2 gene encodes the excitatory amino acid transporter 2 (EAAT2). Glutamate is the major mediator of excitatory neurotransmiss …
Epigenetic Alterations of Brain Non-Neuronal Cells in Major Mental Diseases.
Abdolmaleky HM, Martin M, Zhou JR, Thiagalingam S. Abdolmaleky HM, et al. Genes (Basel). 2023 Apr 12;14(4):896. doi: 10.3390/genes14040896. Genes (Basel). 2023. PMID: 37107654 Free PMC article. Review.
The tissue-specific expression and epigenetic dysregulation of many genes in cells derived from the postmortem brains of patients have been reported to provide a fundamental biological framework for major mental diseases such as autism, schizophrenia, bipolar disorder, and …
The tissue-specific expression and epigenetic dysregulation of many genes in cells derived from the postmortem brains of patients have been …
The Role of Glutamatergic Gene Polymorphisms in the Clinical Phenotypes of Schizophrenia.
Poltavskaya EG, Kornetova EG, Freidin MB, Pozhidaev IV, Paderina DZ, Bocharova AV, Semke AV, Bokhan NA, Ivanova SA, Fedorenko OY. Poltavskaya EG, et al. Genes (Basel). 2023 Feb 24;14(3):575. doi: 10.3390/genes14030575. Genes (Basel). 2023. PMID: 36980845 Free PMC article.
Abnormal glutamatergic neurotransmitter system functioning is integrated in the pathogenesis of schizophrenia. METHODS: A sample of 805 Russian schizophrenia patients from the Siberian Federal region was investigated. We examined the association of 39 single nucleot …
Abnormal glutamatergic neurotransmitter system functioning is integrated in the pathogenesis of schizophrenia. METHODS: A sample of 8 …
Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling.
Veldic M, Millischer V, Port JD, Ho AM, Jia YF, Geske JR, Biernacka JM, Backlund L, McElroy SL, Bond DJ, Villaescusa JC, Skime M, Choi DS, Lavebratt C, Schalling M, Frye MA. Veldic M, et al. Transl Psychiatry. 2019 May 23;9(1):149. doi: 10.1038/s41398-019-0483-9. Transl Psychiatry. 2019. PMID: 31123248 Free PMC article.
This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spectroscopy ((1)H-MRS), and single-nucleotide polymorphisms (SNPs) from four genes (GLUL, SLC1A3, SLC1A2, and SLC1A7) that regulate the …
This study investigated the relationship between the anterior cingulate cortex (AC) glutamate, as measured by proton magnetic resonance spec …
Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia.
Fedorenko OY, Paderina DZ, Kornetova EG, Poltavskaya EG, Pozhidaev IV, Goncharova AA, Freidin MB, Bocharova AV, Bokhan NA, Loonen AJM, Ivanova SA. Fedorenko OY, et al. Diagnostics (Basel). 2022 Jun 22;12(7):1521. doi: 10.3390/diagnostics12071521. Diagnostics (Basel). 2022. PMID: 35885427 Free PMC article.
METHODS: A set of 46 SNPs of the glutamatergic system genes (GRIN2A, GRIN2B, GRIK4, GRM3, GRM7, GRM8, SLC1A2, SLC1A3, SLC17A7) was studied in a population of 704 Caucasian patients with schizophrenia. ...CONCLUSIONS: Genes encoding for mGlu3, EAAT2, and EAAT1 may be …
METHODS: A set of 46 SNPs of the glutamatergic system genes (GRIN2A, GRIN2B, GRIK4, GRM3, GRM7, GRM8, SLC1A2, SLC1A3, SLC17A7) was st …
Association study of the excitatory amino acid transporter 2 (EAAT2) and glycine transporter 1 (GlyT1) gene polymorphism with schizophrenia in a Polish population.
Merk W, Kucia K, Mędrala T, Kowalczyk M, Owczarek A, Kowalski J. Merk W, et al. Neuropsychiatr Dis Treat. 2019 Apr 24;15:989-1000. doi: 10.2147/NDT.S194924. eCollection 2019. Neuropsychiatr Dis Treat. 2019. PMID: 31118638 Free PMC article.
Aim: The aim of this study was to evaluate whether the functional polymorphism-181 A/C (rs4354668) of the SLC1A2 and the rs2486001 (IVS3+411 G/A) in the SLC6A9 are involved in schizophrenia development and its clinical picture in the Polish population. ...Conclusion …
Aim: The aim of this study was to evaluate whether the functional polymorphism-181 A/C (rs4354668) of the SLC1A2 and the rs2486001 (I …
42 results