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    Results: 1 to 20 of 98

    1.

    Drosophila O-GlcNAc transferase (OGT) is encoded by the Polycomb group (PcG) gene, super sex combs (sxc).

    Sinclair DA, Syrzycka M, Macauley MS, Rastgardani T, Komljenovic I, Vocadlo DJ, Brock HW, Honda BM.

    Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13427-32. Epub 2009 Jul 28.PMID: 19666537 [PubMed - indexed for MEDLINE]Related articles

    2.

    The ageing epigenome: damaged beyond repair?

    Sinclair DA, Oberdoerffer P.

    Ageing Res Rev. 2009 Jul;8(3):189-98. Epub 2009 May 9. Review.PMID: 19439199 [PubMed - indexed for MEDLINE]Related articles

    3.

    Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3.

    Jin L, Galonek H, Israelian K, Choy W, Morrison M, Xia Y, Wang X, Xu Y, Yang Y, Smith JJ, Hoffmann E, Carney DP, Perni RB, Jirousek MR, Bemis JE, Milne JC, Sinclair DA, Westphal CH.

    Protein Sci. 2009 Mar;18(3):514-25.PMID: 19241369 [PubMed - indexed for MEDLINE]Related articles

    4.

    NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

    Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P.

    Aging Cell. 2009 Apr;8(2):140-51. Epub 2009 Feb 23.PMID: 19239415 [PubMed - indexed for MEDLINE]Related articles

    5.

    SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.

    Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.

    Cell. 2008 Nov 28;135(5):907-18.PMID: 19041753 [PubMed - indexed for MEDLINE]Related articles

    6.

    The Drosophila cohesin subunit Rad21 is a trithorax group (trxG) protein.

    Hallson G, Syrzycka M, Beck SA, Kennison JA, Dorsett D, Page SL, Hunter SM, Keall R, Warren WD, Brock HW, Sinclair DA, Honda BM.

    Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12405-10. Epub 2008 Aug 19.PMID: 18713858 [PubMed - indexed for MEDLINE]Related articlesFree article

    7.

    Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.

    Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R.

    Cell Metab. 2008 Aug;8(2):157-68. Epub 2008 Jul 3.PMID: 18599363 [PubMed - indexed for MEDLINE]Related articlesFree article

    8.

    Xenohormesis: sensing the chemical cues of other species.

    Howitz KT, Sinclair DA.

    Cell. 2008 May 2;133(3):387-91.PMID: 18455976 [PubMed - indexed for MEDLINE]Related articlesFree article

    9.

    The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth.

    Firestein R, Blander G, Michan S, Oberdoerffer P, Ogino S, Campbell J, Bhimavarapu A, Luikenhuis S, de Cabo R, Fuchs C, Hahn WC, Guarente LP, Sinclair DA.

    PLoS One. 2008 Apr 16;3(4):e2020.PMID: 18414679 [PubMed - indexed for MEDLINE]Related articlesFree article

    10.

    David A. Sinclair, Ph.D is interviewed by Vicki Glaser.

    Sinclair DA.

    Rejuvenation Res. 2008 Feb;11(1):265-8. No abstract available. PMID: 18279035 [PubMed - indexed for MEDLINE]Related articles

    11.

    Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

    Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.

    Nature. 2007 Nov 29;450(7170):712-6.PMID: 18046409 [PubMed - indexed for MEDLINE]Related articlesFree article

    12.

    MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

    Medvedik O, Lamming DW, Kim KD, Sinclair DA.

    PLoS Biol. 2007 Oct 2;5(10):e261.PMID: 17914901 [PubMed - indexed for MEDLINE]Related articlesFree article

    13.

    Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

    Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.

    Cell. 2007 Sep 21;130(6):1095-107.PMID: 17889652 [PubMed - indexed for MEDLINE]Related articles

    14.

    Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation.

    Li Y, Yokota T, Gama V, Yoshida T, Gomez JA, Ishikawa K, Sasaguri H, Cohen HY, Sinclair DA, Mizusawa H, Matsuyama S.

    Cell Death Differ. 2007 Dec;14(12):2058-67. Epub 2007 Sep 21.PMID: 17885668 [PubMed - indexed for MEDLINE]Related articlesFree article

    15.

    The role of nuclear architecture in genomic instability and ageing.

    Oberdoerffer P, Sinclair DA.

    Nat Rev Mol Cell Biol. 2007 Sep;8(9):692-702. Review.PMID: 17700626 [PubMed - indexed for MEDLINE]Related articles

    16.

    Caloric restriction and life span determination of yeast cells.

    Medvedik O, Sinclair DA.

    Methods Mol Biol. 2007;371:97-109.PMID: 17634577 [PubMed - indexed for MEDLINE]Related articles

    17.

    The pink gene encodes the Drosophila orthologue of the human Hermansky-Pudlak syndrome 5 (HPS5) gene.

    Syrzycka M, McEachern LA, Kinneard J, Prabhu K, Fitzpatrick K, Schulze S, Rawls JM, Lloyd VK, Sinclair DA, Honda BM.

    Genome. 2007 Jun;50(6):548-56.PMID: 17632576 [PubMed - indexed for MEDLINE]Related articles

    18.

    SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH.

    EMBO J. 2007 Jul 11;26(13):3169-79. Epub 2007 Jun 21.PMID: 17581637 [PubMed - indexed for MEDLINE]Related articlesFree article

    19.

    Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.

    Calabrese EJ, Bachmann KA, Bailer AJ, Bolger PM, Borak J, Cai L, Cedergreen N, Cherian MG, Chiueh CC, Clarkson TW, Cook RR, Diamond DM, Doolittle DJ, Dorato MA, Duke SO, Feinendegen L, Gardner DE, Hart RW, Hastings KL, Hayes AW, Hoffmann GR, Ives JA, Jaworowski Z, Johnson TE, Jonas WB, Kaminski NE, Keller JG, Klaunig JE, Knudsen TB, Kozumbo WJ, Lettieri T, Liu SZ, Maisseu A, Maynard KI, Masoro EJ, McClellan RO, Mehendale HM, Mothersill C, Newlin DB, Nigg HN, Oehme FW, Phalen RF, Philbert MA, Rattan SI, Riviere JE, Rodricks J, Sapolsky RM, Scott BR, Seymour C, Sinclair DA, Smith-Sonneborn J, Snow ET, Spear L, Stevenson DE, Thomas Y, Tubiana M, Williams GM, Mattson MP.

    Toxicol Appl Pharmacol. 2007 Jul 1;222(1):122-8. Epub 2007 Mar 7. Review.PMID: 17459441 [PubMed - indexed for MEDLINE]Related articles

    20.

    The role of protein arginine methylation in the formation of silent chromatin.

    Yu MC, Lamming DW, Eskin JA, Sinclair DA, Silver PA.

    Genes Dev. 2006 Dec 1;20(23):3249-54.PMID: 17158743 [PubMed - indexed for MEDLINE]Related articlesFree article

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