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Results: 1 to 20 of 66

1.

The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation.

Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J.

Mol Cell. 2015 Jan 21. pii: S1097-2765(14)00999-X. doi: 10.1016/j.molcel.2014.12.021. [Epub ahead of print]

PMID:
25620563
[PubMed - as supplied by publisher]
2.

Isolating potentiated Hsp104 variants using yeast proteinopathy models.

Jackrel ME, Tariq A, Yee K, Weitzman R, Shorter J.

J Vis Exp. 2014 Nov 11;(93):e52089. doi: 10.3791/52089.

PMID:
25407485
[PubMed - in process]
3.

Suramin inhibits Hsp104 ATPase and disaggregase activity.

Torrente MP, Castellano LM, Shorter J.

PLoS One. 2014 Oct 9;9(10):e110115. doi: 10.1371/journal.pone.0110115. eCollection 2014.

PMID:
25299406
[PubMed - in process]
Free PMC Article
4.

Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.

Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J.

Biochem J. 2014 Nov 15;464(1):85-98. doi: 10.1042/BJ20131609.

PMID:
25142005
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins.

Jackrel ME, Shorter J.

Dis Model Mech. 2014 Oct;7(10):1175-84. doi: 10.1242/dmm.016113. Epub 2014 Jul 25.

PMID:
25062688
[PubMed - in process]
Free PMC Article
6.

A cellular system that degrades misfolded proteins and protects against neurodegeneration.

Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X.

Mol Cell. 2014 Jul 3;55(1):15-30. doi: 10.1016/j.molcel.2014.04.030. Epub 2014 May 29.

PMID:
24882209
[PubMed - indexed for MEDLINE]
7.

Reversing deleterious protein aggregation with re-engineered protein disaggregases.

Jackrel ME, Shorter J.

Cell Cycle. 2014 May 1;13(9):1379-83. doi: 10.4161/cc.28709. Epub 2014 Apr 2.

PMID:
24694655
[PubMed - in process]
8.

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.

Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J.

Cell. 2014 Jan 16;156(1-2):170-82. doi: 10.1016/j.cell.2013.11.047.

PMID:
24439375
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins.

Torrente MP, Shorter J.

Prion. 2013 Nov-Dec;7(6):457-63. Epub 2014 Jan 8.

PMID:
24401655
[PubMed - in process]
10.

Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation.

Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J.

J Biol Chem. 2014 Jan 10;289(2):848-67. doi: 10.1074/jbc.M113.520759. Epub 2013 Nov 26.

PMID:
24280225
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model.

Cushman-Nick M, Bonini NM, Shorter J.

PLoS Genet. 2013;9(9):e1003781. doi: 10.1371/journal.pgen.1003781. Epub 2013 Sep 5.

PMID:
24039611
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fission yeast does not age under favorable conditions, but does so after stress.

Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolić-Nørrelykke IM.

Curr Biol. 2013 Oct 7;23(19):1844-52. doi: 10.1016/j.cub.2013.07.084. Epub 2013 Sep 12.

PMID:
24035542
[PubMed - indexed for MEDLINE]
Free Article
13.

Stress granules as crucibles of ALS pathogenesis.

Li YR, King OD, Shorter J, Gitler AD.

J Cell Biol. 2013 Apr 29;201(3):361-72. doi: 10.1083/jcb.201302044. Review.

PMID:
23629963
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, Pinkus JL, Greenberg SA, Trojanowski JQ, Traynor BJ, Smith BN, Topp S, Gkazi AS, Miller J, Shaw CE, Kottlors M, Kirschner J, Pestronk A, Li YR, Ford AF, Gitler AD, Benatar M, King OD, Kimonis VE, Ross ED, Weihl CC, Shorter J, Taylor JP.

Nature. 2013 Mar 28;495(7442):467-73. doi: 10.1038/nature11922. Epub 2013 Mar 3.

PMID:
23455423
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly.

Shorter J, Taylor JP.

Rare Dis. 2013 May 29;1:e25200. doi: 10.4161/rdis.25200. eCollection 2013.

PMID:
25002999
[PubMed]
Free PMC Article
16.

Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)].

DeSantis ME, Shorter J.

Chem Biol. 2012 Nov 21;19(11):1400-10. doi: 10.1016/j.chembiol.2012.09.013.

PMID:
23177195
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients.

DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J.

Cell. 2012 Nov 9;151(4):778-93. doi: 10.1016/j.cell.2012.09.038.

PMID:
23141537
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.

Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV Jr, Gitler AD.

Nat Genet. 2012 Dec;44(12):1302-9. doi: 10.1038/ng.2434. Epub 2012 Oct 28.

PMID:
23104007
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration.

Ugras SE, Shorter J.

Neurol Res Int. 2012;2012:432780. doi: 10.1155/2012/432780. Epub 2012 Apr 19.

PMID:
22919483
[PubMed]
Free PMC Article
20.

Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans.

Duennwald ML, Echeverria A, Shorter J.

PLoS Biol. 2012;10(6):e1001346. doi: 10.1371/journal.pbio.1001346. Epub 2012 Jun 19.

PMID:
22723742
[PubMed - indexed for MEDLINE]
Free PMC Article

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