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2005 2
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SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models.
Kwon OC, Song JJ, Yang Y, Kim SH, Kim JY, Seok MJ, Hwang I, Yu JW, Karmacharya J, Maeng HJ, Kim J, Jho EH, Ko SY, Son H, Chang MY, Lee SH. Kwon OC, et al. EMBO Mol Med. 2021 Apr 9;13(4):e13076. doi: 10.15252/emmm.202013076. Epub 2021 Mar 1. EMBO Mol Med. 2021. PMID: 33646633 Free PMC article.
Astrocytes and microglia are brain-resident glia that can establish harmful inflammatory environments in disease contexts and thereby contribute to the progression of neuronal loss in neurodegenerative disorders. ...Furthermore, SGK1 inhibition potentiated gl …
Astrocytes and microglia are brain-resident glia that can establish harmful inflammatory environments in disease contexts and thereby …
Association between SGK1 and alpha-synuclein in skeletal muscle in an MPTP-induced Parkinson's disease model.
Heo EJ, Lee Y, Hyung Seo M, Yeo S. Heo EJ, et al. Neurosci Lett. 2023 Sep 25;814:137464. doi: 10.1016/j.neulet.2023.137464. Epub 2023 Aug 25. Neurosci Lett. 2023. PMID: 37634811
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the substantia nigra and it is known to involve the accumulation of alpha-synuclein (alpha-syn), which is a neuroprotein that promotes degeneration of dop …
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the substantia …
Association between Decreased SGK1 and Increased Intestinal alpha-Synuclein in an MPTP Mouse Model of Parkinson's Disease.
Seo MH, Kwon D, Kim SH, Yeo S. Seo MH, et al. Int J Mol Sci. 2023 Nov 16;24(22):16408. doi: 10.3390/ijms242216408. Int J Mol Sci. 2023. PMID: 38003598 Free PMC article.
Parkinson's disease (PD) is a globally common progressive neurodegenerative disease resulting from the loss of dopaminergic neurons in the brain. ...Gastrointestinal disorders are some of the major prodromal symptoms of PD. Therefore, modulating …
Parkinson's disease (PD) is a globally common progressive neurodegenerative disease resulting from the loss of d …
High-fat diet-induced activation of SGK1 promotes Alzheimer's disease-associated tau pathology.
Elahi M, Motoi Y, Shimonaka S, Ishida Y, Hioki H, Takanashi M, Ishiguro K, Imai Y, Hattori N. Elahi M, et al. Hum Mol Genet. 2021 Aug 28;30(18):1693-1710. doi: 10.1093/hmg/ddab115. Hum Mol Genet. 2021. PMID: 33890983 Free PMC article.
Elevated expression of SGK1 in the mouse hippocampus led to neurodegeneration and impairments in learning and memory. Upregulation and activation of SGK1, SGK1-GSK-3ss-tau complex were also observed in the hippocampi of AD cases. ...
Elevated expression of SGK1 in the mouse hippocampus led to neurodegeneration and impairments in learning and memory. Upregulation an …
Significance of SGK1 in the regulation of neuronal function.
Lang F, Strutz-Seebohm N, Seebohm G, Lang UE. Lang F, et al. J Physiol. 2010 Sep 15;588(Pt 18):3349-54. doi: 10.1113/jphysiol.2010.190926. Epub 2010 Jun 7. J Physiol. 2010. PMID: 20530112 Free PMC article. Review.
Parkinson's disease, schizophrenia, depression, Alzheimer's disease). Despite multiple SGK1 functions, the phenotype of the SGK1 knockout mouse is mild and becomes only apparent under challenging conditions....
Parkinson's disease, schizophrenia, depression, Alzheimer's disease). Despite multiple SGK1 functions, th …
Genetics of Parkinson's disease heterogeneity: A genome-wide association study of clinical subtypes.
Dulski J, Uitti RJ, Beasley A, Hernandez D, Ramanan VK, Cahn EJ, Ren Y, Johnson PW, Quicksall ZS, Wszolek ZK, Ross OA, Heckman MG. Dulski J, et al. Parkinsonism Relat Disord. 2024 Feb;119:105935. doi: 10.1016/j.parkreldis.2023.105935. Epub 2023 Nov 26. Parkinsonism Relat Disord. 2024. PMID: 38072719
INTRODUCTION: Substantial heterogeneity between individual patients in the clinical presentation of Parkinson's disease (PD) has led to the classification of distinct PD subtypes. ...Replication of these findings will be important in order to better define th …
INTRODUCTION: Substantial heterogeneity between individual patients in the clinical presentation of Parkinson's disease …
sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson's disease.
Stichel CC, Schoenebeck B, Foguet M, Siebertz B, Bader V, Zhu XR, Lübbert H. Stichel CC, et al. Eur J Neurosci. 2005 Jan;21(2):301-16. doi: 10.1111/j.1460-9568.2005.03859.x. Eur J Neurosci. 2005. PMID: 15673431
In an effort to gain deeper insight into the molecular processes underlying neurodegeneration in Parkinson's disease, we performed gene expression profiling at several early time points after MPTP-injection into old (1-year) mice. ...We selected one of the st …
In an effort to gain deeper insight into the molecular processes underlying neurodegeneration in Parkinson's disease, w …
Neurons, Erythrocytes and Beyond -The Diverse Functions of Chorein.
Lang F, Pelzl L, Schöls L, Hermann A, Föller M, Schäffer TE, Stournaras C. Lang F, et al. Neurosignals. 2017;25(1):117-126. doi: 10.1159/000485457. Epub 2017 Nov 28. Neurosignals. 2017. PMID: 29179176 Free article. Review.
Chorea-acanthocytosis (ChAc), a neurodegenerative disease, results from loss-of-function-mutations of the chorein-encoding gene VPS13A. ...ORAI1 expression, SOCE and cell survival can be restored by lithium treatment, an effect disrupted by pharmacological inhibition of …
Chorea-acanthocytosis (ChAc), a neurodegenerative disease, results from loss-of-function-mutations of the chorein-encoding gene VPS13 …
S-Nitrosylation at the active site decreases the ubiquitin-conjugating activity of ubiquitin-conjugating enzyme E2 D1 (UBE2D1), an ERAD-associated protein.
Fujikawa K, Nakahara K, Takasugi N, Nishiya T, Ito A, Uchida K, Uehara T. Fujikawa K, et al. Biochem Biophys Res Commun. 2020 Apr 16;524(4):910-915. doi: 10.1016/j.bbrc.2020.02.011. Epub 2020 Feb 10. Biochem Biophys Res Commun. 2020. PMID: 32051088 Free article.
In the present study, we found that the ubiquitination of a known ERAD substrate, serine/threonine-protein kinase 1 (SGK1), is attenuated by nitrosative stress. C-terminus of Hsc70-interacting protein (CHIP) together with ubiquitin-conjugating enzyme E2 D1 (UBE2D1) are inv …
In the present study, we found that the ubiquitination of a known ERAD substrate, serine/threonine-protein kinase 1 (SGK1), is attenu …
Sgk1, a cell survival response in neurodegenerative diseases.
Schoenebeck B, Bader V, Zhu XR, Schmitz B, Lübbert H, Stichel CC. Schoenebeck B, et al. Mol Cell Neurosci. 2005 Oct;30(2):249-64. doi: 10.1016/j.mcn.2005.07.017. Mol Cell Neurosci. 2005. PMID: 16125969
Recent evidence for the involvement of sgk1 in the early pathogenesis of MPTP-induced Parkinson's disease (PD) prompted us to investigate in more detail its expression and role in animal models of different neurodegenerative diseases. ...These findings …
Recent evidence for the involvement of sgk1 in the early pathogenesis of MPTP-induced Parkinson's disease (PD) p …
15 results