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Results: 1 to 20 of 38


Surface Density-Induced Pleating of a Lipid Monolayer Drives Nascent High-Density Lipoprotein Assembly.

Segrest JP, Jones MK, Catte A, Manchekar M, Datta G, Zhang L, Zhang R, Li L, Patterson JC, Palgunachari MN, Oram JF, Ren G.

Structure. 2015 Jul 7;23(7):1214-26. doi: 10.1016/j.str.2015.05.010. Epub 2015 Jun 18.


A robust all-atom model for LCAT generated by homology modeling.

Segrest JP, Jones MK, Catte A, Thirumuruganandham SP.

J Lipid Res. 2015 Mar;56(3):620-34. doi: 10.1194/jlr.M056382. Epub 2015 Jan 14.


An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations.

Segrest JP, Jones MK, Shao B, Heinecke JW.

Biochemistry. 2014 Dec 9;53(48):7625-40. doi: 10.1021/bi501111j. Epub 2014 Nov 25.


The structure of human apolipoprotein A-IV as revealed by stable isotope-assisted cross-linking, molecular dynamics, and small angle x-ray scattering.

Walker RG, Deng X, Melchior JT, Morris J, Tso P, Jones MK, Segrest JP, Thompson TB, Davidson WS.

J Biol Chem. 2014 Feb 28;289(9):5596-608. doi: 10.1074/jbc.M113.541037. Epub 2014 Jan 14.


Structural basis for distinct functions of the naturally occurring Cys mutants of human apolipoprotein A-I.

Gursky O, Jones MK, Mei X, Segrest JP, Atkinson D.

J Lipid Res. 2013 Dec;54(12):3244-57. doi: 10.1194/jlr.R037911. Epub 2013 Sep 13. Review.


Volumetric determination of apolipoprotein stoichiometry of circulating HDL subspecies.

Segrest JP, Cheung MC, Jones MK.

J Lipid Res. 2013 Oct;54(10):2733-44. doi: 10.1194/jlr.M039172. Epub 2013 Jul 23.


MD simulations suggest important surface differences between reconstituted and circulating spherical HDL.

Segrest JP, Jones MK, Catte A.

J Lipid Res. 2013 Oct;54(10):2718-32. doi: 10.1194/jlr.M039206. Epub 2013 Jul 15.


Helical domains that mediate lipid solubilization and ABCA1-specific cholesterol efflux in apolipoproteins C-I and A-II.

Smith LE, Segrest JP, Davidson WS.

J Lipid Res. 2013 Jul;54(7):1939-48. doi: 10.1194/jlr.M037903. Epub 2013 Apr 25.


Validation of previous computer models and MD simulations of discoidal HDL by a recent crystal structure of apoA-I.

Segrest JP, Jones MK, Catte A, Thirumuruganandham SP.

J Lipid Res. 2012 Sep;53(9):1851-63. doi: 10.1194/jlr.M026229. Epub 2012 Jul 8.


Sidedness of interfacial arginine residues and anti-atherogenicity of apolipoprotein A-I mimetic peptides.

Nayyar G, Mishra VK, Handattu SP, Palgunachari MN, Shin R, McPherson DT, Deivanayagam CC, Garber DW, Segrest JP, Anantharamaiah GM.

J Lipid Res. 2012 May;53(5):849-58. doi: 10.1194/jlr.M019844. Epub 2012 Feb 29.


Rotational and hinge dynamics of discoidal high density lipoproteins probed by interchain disulfide bond formation.

Li L, Li S, Jones MK, Segrest JP.

Biochim Biophys Acta. 2012 Mar;1821(3):481-9. doi: 10.1016/j.bbalip.2011.10.013. Epub 2011 Oct 19.


"Sticky" and "promiscuous", the yin and yang of apolipoprotein A-I termini in discoidal high-density lipoproteins: a combined computational-experimental approach.

Jones MK, Gu F, Catte A, Li L, Segrest JP.

Biochemistry. 2011 Mar 29;50(12):2249-63. doi: 10.1021/bi101301g. Epub 2011 Mar 4.


Sequence conservation of apolipoprotein A-I affords novel insights into HDL structure-function.

Bashtovyy D, Jones MK, Anantharamaiah GM, Segrest JP.

J Lipid Res. 2011 Mar;52(3):435-50. doi: 10.1194/jlr.R012658. Epub 2010 Dec 14. Review.


Assessment of the validity of the double superhelix model for reconstituted high density lipoproteins: a combined computational-experimental approach.

Jones MK, Zhang L, Catte A, Li L, Oda MN, Ren G, Segrest JP.

J Biol Chem. 2010 Dec 24;285(52):41161-71. doi: 10.1074/jbc.M110.187799. Epub 2010 Oct 25.


Structures of discoidal high density lipoproteins: a combined computational-experimental approach.

Gu F, Jones MK, Chen J, Patterson JC, Catte A, Jerome WG, Li L, Segrest JP.

J Biol Chem. 2010 Feb 12;285(7):4652-65. doi: 10.1074/jbc.M109.069914. Epub 2009 Nov 30.


Dynamics of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I.

Jones MK, Catte A, Li L, Segrest JP.

Biochemistry. 2009 Dec 1;48(47):11196-210. doi: 10.1021/bi901242k.


Thermal stability of apolipoprotein A-I in high-density lipoproteins by molecular dynamics.

Jones MK, Catte A, Patterson JC, Gu F, Chen J, Li L, Segrest JP.

Biophys J. 2009 Jan;96(2):354-71. doi: 10.1016/j.bpj.2008.09.041.


Effect of leucine to phenylalanine substitution on the nonpolar face of a class A amphipathic helical peptide on its interaction with lipid: high resolution solution NMR studies of 4F-dimyristoylphosphatidylcholine discoidal complex.

Mishra VK, Palgunachari MN, Krishna R, Glushka J, Segrest JP, Anantharamaiah GM.

J Biol Chem. 2008 Dec 5;283(49):34393-402. doi: 10.1074/jbc.M806384200. Epub 2008 Oct 9.


Charged amino acid residues 997-1000 of human apolipoprotein B100 are critical for the initiation of lipoprotein assembly and the formation of a stable lipidated primordial particle in McA-RH7777 cells.

Manchekar M, Richardson PE, Sun Z, Liu Y, Segrest JP, Dashti N.

J Biol Chem. 2008 Oct 24;283(43):29251-65. doi: 10.1074/jbc.M804912200. Epub 2008 Aug 25.


The editor's roundtable: expanded versus standard lipid panels in assessing and managing cardiovascular risk.

Sulkes D, Brown BG, Krauss RM, Segrest JP, Sniderman AD, Roberts WC.

Am J Cardiol. 2008 Mar 15;101(6):828-42. doi: 10.1016/j.amjcard.2007.12.006. Review. No abstract available.

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