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Results: 1 to 20 of 57

1.

PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.

Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P.

Genes Dev. 2015 Feb 1;29(3):298-307. doi: 10.1101/gad.252734.114.

PMID:
25644604
2.

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.

Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D.

Nature. 2015 Mar 12;519(7542):242-6. doi: 10.1038/nature14115. Epub 2014 Dec 22.

PMID:
25533952
3.

Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.

Bartesaghi S, Hallen S, Huang L, Svensson PA, Momo RA, Wallin S, Carlsson EK, Forslöw A, Seale P, Peng XR.

Mol Endocrinol. 2015 Jan;29(1):130-9. doi: 10.1210/me.2014-1295.

PMID:
25389910
4.

Ebf2 is a selective marker of brown and beige adipogenic precursor cells.

Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):14466-71. doi: 10.1073/pnas.1412685111. Epub 2014 Sep 2.

5.

Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis.

Lim MA, Bence KK, Sandesara I, Andreux P, Auwerx J, Ishibashi J, Seale P, Kalb RG.

Hum Mol Genet. 2014 Sep 15;23(18):4995-5008. doi: 10.1093/hmg/ddu214. Epub 2014 May 15.

PMID:
24833719
6.

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.

Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P.

Cell Metab. 2014 Apr 1;19(4):593-604. doi: 10.1016/j.cmet.2014.03.007.

7.

p107 is a crucial regulator for determining the adipocyte lineage fate choices of stem cells.

De Sousa M, Porras DP, Perry CG, Seale P, Scimè A.

Stem Cells. 2014 May;32(5):1323-36. doi: 10.1002/stem.1637.

8.

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM.

Cell. 2014 Jan 16;156(1-2):304-16. doi: 10.1016/j.cell.2013.12.021.

9.

The nuclear receptor Rev-erbα controls circadian thermogenic plasticity.

Gerhart-Hines Z, Feng D, Emmett MJ, Everett LJ, Loro E, Briggs ER, Bugge A, Hou C, Ferrara C, Seale P, Pryma DA, Khurana TS, Lazar MA.

Nature. 2013 Nov 21;503(7476):410-3. doi: 10.1038/nature12642. Epub 2013 Oct 27.

10.

Brown and beige fat: development, function and therapeutic potential.

Harms M, Seale P.

Nat Med. 2013 Oct;19(10):1252-63. doi: 10.1038/nm.3361. Epub 2013 Sep 29. Review.

PMID:
24100998
11.

Brown adipose tissue biology and therapeutic potential.

Seale P.

Front Endocrinol (Lausanne). 2013 Mar 19;4:14. doi: 10.3389/fendo.2013.00014. eCollection 2013. No abstract available.

12.

EBF2 determines and maintains brown adipocyte identity.

Rajakumari S, Wu J, Ishibashi J, Lim HW, Giang AH, Won KJ, Reed RR, Seale P.

Cell Metab. 2013 Apr 2;17(4):562-74. doi: 10.1016/j.cmet.2013.01.015. Epub 2013 Mar 14.

13.

MicroRNA-133 controls brown adipose determination in skeletal muscle satellite cells by targeting Prdm16.

Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van Ijcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA.

Cell Metab. 2013 Feb 5;17(2):210-24. doi: 10.1016/j.cmet.2013.01.004.

14.

Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity.

Derecka M, Gornicka A, Koralov SB, Szczepanek K, Morgan M, Raje V, Sisler J, Zhang Q, Otero D, Cichy J, Rajewsky K, Shimoda K, Poli V, Strobl B, Pellegrini S, Harris TE, Seale P, Russell AP, McAinch AJ, O'Brien PE, Keller SR, Croniger CM, Kordula T, Larner AC.

Cell Metab. 2012 Dec 5;16(6):814-24. doi: 10.1016/j.cmet.2012.11.005.

15.

An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.

Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P.

Mol Cell Biol. 2012 Jun;32(12):2289-99. doi: 10.1128/MCB.06529-11. Epub 2012 Apr 2.

16.

Orexin turns up the heat on obesity.

Seale P.

Cell Metab. 2011 Oct 5;14(4):441-2. doi: 10.1016/j.cmet.2011.09.007.

17.

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.

Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM.

J Clin Invest. 2011 Jan;121(1):96-105. doi: 10.1172/JCI44271. Epub 2010 Dec 1.

18.

Transcriptional control of brown adipocyte development and thermogenesis.

Seale P.

Int J Obes (Lond). 2010 Oct;34 Suppl 1:S17-22. doi: 10.1038/ijo.2010.178.

PMID:
20935660
19.

Validity of a continuous metabolic risk score as an index for modeling metabolic syndrome in adolescents.

Okosun IS, Lyn R, Davis-Smith M, Eriksen M, Seale P.

Ann Epidemiol. 2010 Nov;20(11):843-51. doi: 10.1016/j.annepidem.2010.08.001.

PMID:
20933191
20.

Medicine. Beige can be slimming.

Ishibashi J, Seale P.

Science. 2010 May 28;328(5982):1113-4. doi: 10.1126/science.1190816. Epub 2010 May 6. No abstract available.

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