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717 results

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Schizandrin A can inhibit non-small cell lung cancer cell proliferation by inducing cell cycle arrest, apoptosis and autophagy.
Zhu L, Wang Y, Lv W, Wu X, Sheng H, He C, Hu J. Zhu L, et al. Int J Mol Med. 2021 Dec;48(6):214. doi: 10.3892/ijmm.2021.5047. Epub 2021 Oct 13. Int J Mol Med. 2021. PMID: 34643254 Free PMC article.
Schizandrin A (SchA) can be extracted from the vine plant Schisandra chinensis and has been reported to confer various biologically active properties. ...
Schizandrin A (SchA) can be extracted from the vine plant Schisandra chinensis and has been reported to confer various biologically a
Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-kappaB and p38/ERK MAPK signaling pathways.
Chen P, Wang R, Liu F, Li S, Gu Y, Wang L, Yuan Y. Chen P, et al. Front Pharmacol. 2023 May 23;14:1092151. doi: 10.3389/fphar.2023.1092151. eCollection 2023. Front Pharmacol. 2023. PMID: 37288106 Free PMC article.
In addition, Schizandrin C reduced the expressions of alpha-smooth muscle actin and type iota collagen in the liver. ...These findings supported Schizandrin C as a potential drug for liver fibrosis....
In addition, Schizandrin C reduced the expressions of alpha-smooth muscle actin and type iota collagen in the liver. ...These finding …
Schizandrin protects H9c2 cells against lipopolysaccharide-induced injury by downregulating Smad3.
Zhang X, Zhao Y, Bai D, Yuan X, Cong S. Zhang X, et al. J Biochem Mol Toxicol. 2019 May;33(5):e22301. doi: 10.1002/jbt.22301. Epub 2019 Feb 22. J Biochem Mol Toxicol. 2019. PMID: 30801894
Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) ...Besides this, Smad3 was a downstream effector of schizandrin. The beneficial effects of schizandrin on the H9c2 cells were attenuated when Smad3 was overexpressed. ...
Schizandrin is a major bioactive constituent of Schisandra chinensis (Turcz.) ...Besides this, Smad3 was a downstream effector of
Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway.
Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY, Zhao S. Zhao B, et al. Exp Ther Med. 2021 Mar;21(3):220. doi: 10.3892/etm.2021.9651. Epub 2021 Jan 18. Exp Ther Med. 2021. PMID: 33603829 Free PMC article.
Schizandrin B exhibits prominent antioxidant and anti-inflammatory effects, and plays an important role in ameliorating myocardial ischemia/reperfusion injury. ...Furthermore, schizandrin B enhanced phosphorylated (p)-AMPK expression, while AMPK knockdown induced by
Schizandrin B exhibits prominent antioxidant and anti-inflammatory effects, and plays an important role in ameliorating myocardial is
Schizandrin attenuates lung lesions induced by Avian pathogenic Escherichia coli in chickens.
Yuan M, Peng LY, Wei Q, Li JH, Song K, Chen S, Huang JN, Yu JL, An Q, Yi PF, Shen HQ, Fu BD. Yuan M, et al. Microb Pathog. 2020 Feb 11;142:104059. doi: 10.1016/j.micpath.2020.104059. Online ahead of print. Microb Pathog. 2020. PMID: 32058027
The purpose of this study was to investigate the protective effect of schizandrin on APEC-induced lung lesions in chickens and explore the potential mechanism of schizandrin protection. The schizandrin (50, 100, and 200 mg/kg) was intragastrically administere …
The purpose of this study was to investigate the protective effect of schizandrin on APEC-induced lung lesions in chickens and explor …
Schizandrin attenuates inflammation induced by avian pathogenic Escherichia coli in chicken type II pneumocytes.
Yuan M, Peng LY, Wu SC, Li JH, Song K, Chen S, Huang JN, Yu JL, An Q, Yi PF, Shen HQ, Fu BD. Yuan M, et al. Int Immunopharmacol. 2020 Apr;81:106313. doi: 10.1016/j.intimp.2020.106313. Epub 2020 Feb 15. Int Immunopharmacol. 2020. PMID: 32070918
Moreover, schizandrin markedly decreased the levels of IL-1beta, IL-8, IL-6, and TNF-alpha, the mechanism responsible for these effects was attributed to the inhibitory effect of schizandrin on NF-kappaB and MAPK signaling activation. ...The results indicate that …
Moreover, schizandrin markedly decreased the levels of IL-1beta, IL-8, IL-6, and TNF-alpha, the mechanism responsible for these effec …
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3beta/Nrf2 signaling-mediated ferroptosis in vivo and in vitro.
Dong C, Song C, He Z, Song Q, Song T, Liu J, Xiong Y, Su X, Zhou J, Yang S, Liao W. Dong C, et al. Int Immunopharmacol. 2023 Apr;117:110042. doi: 10.1016/j.intimp.2023.110042. Epub 2023 Mar 20. Int Immunopharmacol. 2023. PMID: 36940552
Schizandrin B (SchB) protects against oxidative, inflammatory, and ferroptotic injury. ...
Schizandrin B (SchB) protects against oxidative, inflammatory, and ferroptotic injury. ...
Schizandrin ameliorates behavioral disorders in hepatic injury mice via regulation of oxidative stress and neuroinflammation.
Yan T, Liu B, Li F, Wu B, Xiao F, He B, Jia Y. Yan T, et al. Immunopharmacol Immunotoxicol. 2021 Apr;43(2):212-222. doi: 10.1080/08923973.2021.1879847. Epub 2021 Feb 15. Immunopharmacol Immunotoxicol. 2021. PMID: 33588680
Furthermore, schizandrin could dramatically inhibit the neuroinflammation in mice by reducing pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6) through regulating NF-kappaB/NLRP3/Iba-1 signaling. Besides, the elevated levels of ammonia, AST, and ALT were significa …
Furthermore, schizandrin could dramatically inhibit the neuroinflammation in mice by reducing pro-inflammatory cytokines (TNF-alpha, …
Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/antioxidant enzymes in microglia.
Park SY, Park SJ, Park TG, Rajasekar S, Lee SJ, Choi YW. Park SY, et al. Int Immunopharmacol. 2013 Oct;17(2):415-26. doi: 10.1016/j.intimp.2013.06.032. Epub 2013 Jul 13. Int Immunopharmacol. 2013. PMID: 23859871
Schizandrin C induced expression of phase II detoxifying/antioxidant enzymes including heme oxygenase-1 (HO-1) and NADPH dehydrogenase quinone-1 (NQO-1). ...Schizandrin C also effectively suppressed ROS generation and NO production, as well as iNOS promoter activity
Schizandrin C induced expression of phase II detoxifying/antioxidant enzymes including heme oxygenase-1 (HO-1) and NADPH dehydrogenas
Schizandrin A ameliorates cognitive functions via modulating microglial polarisation in Alzheimer's disease mice.
Wang Q, Liu L, Guan H, Zhou Y, Li Q. Wang Q, et al. Pharm Biol. 2021 Dec;59(1):860-867. doi: 10.1080/13880209.2021.1941132. Pharm Biol. 2021. PMID: 34214019 Free PMC article.
CONTEXT: Schizandrin A (Sch A) is a major phytochemical from Schisandra chinensis (Turcz.) ...
CONTEXT: Schizandrin A (Sch A) is a major phytochemical from Schisandra chinensis (Turcz.) ...
717 results