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Results: 1 to 20 of 62

1.

ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

Han Z, Madara JJ, Liu Y, Liu W, Ruthel G, Freedman BD, Harty RN.

J Infect Dis. 2015 Mar 18. pii: jiu838. [Epub ahead of print]

PMID:
25786915
2.

Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.

Zwack EE, Snyder AG, Wynosky-Dolfi MA, Ruthel G, Philip NH, Marketon MM, Francis MS, Bliska JB, Brodsky IE.

MBio. 2015 Feb 17;6(1):e02095-14. doi: 10.1128/mBio.02095-14.

3.

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Han Z, Lu J, Liu Y, Davis B, Lee MS, Olson MA, Ruthel G, Freedman BD, Schnell MJ, Wrobel JE, Reitz AB, Harty RN.

J Virol. 2014 Jul;88(13):7294-306. doi: 10.1128/JVI.00591-14. Epub 2014 Apr 16.

4.

Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.

Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD.

PLoS One. 2014 Mar 5;9(3):e90390. doi: 10.1371/journal.pone.0090390. eCollection 2014.

5.

A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress.

Lu J, Han Z, Liu Y, Liu W, Lee MS, Olson MA, Ruthel G, Freedman BD, Harty RN.

J Virol. 2014 May;88(9):4736-43. doi: 10.1128/JVI.03757-13. Epub 2014 Feb 12.

6.

Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.

Guha M, Srinivasan S, Ruthel G, Kashina AK, Carstens RP, Mendoza A, Khanna C, Van Winkle T, Avadhani NG.

Oncogene. 2014 Nov 6;33(45):5238-50. doi: 10.1038/onc.2013.467. Epub 2013 Nov 4.

PMID:
24186204
7.

Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis.

Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P.

PLoS Pathog. 2013;9(7):e1003504. doi: 10.1371/journal.ppat.1003504. Epub 2013 Jul 18.

8.

Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway.

Garrison AR, Radoshitzky SR, Kota KP, Pegoraro G, Ruthel G, Kuhn JH, Altamura LA, Kwilas SA, Bavari S, Haucke V, Schmaljohn CS.

Virology. 2013 Sep;444(1-2):45-54. doi: 10.1016/j.virol.2013.05.030. Epub 2013 Jun 19.

9.

Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.

Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN.

J Virol. 2013 Jul;87(13):7777-80. doi: 10.1128/JVI.00470-13. Epub 2013 May 1.

10.

CD44 Promotes intoxication by the clostridial iota-family toxins.

Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H.

PLoS One. 2012;7(12):e51356. doi: 10.1371/journal.pone.0051356. Epub 2012 Dec 7.

11.

Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88.

Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU.

PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27.

12.

Ebola virus entry requires the host-programmed recognition of an intracellular receptor.

Miller EH, Obernosterer G, Raaben M, Herbert AS, Deffieu MS, Krishnan A, Ndungo E, Sandesara RG, Carette JE, Kuehne AI, Ruthel G, Pfeffer SR, Dye JM, Whelan SP, Brummelkamp TR, Chandran K.

EMBO J. 2012 Apr 18;31(8):1947-60. doi: 10.1038/emboj.2012.53. Epub 2012 Mar 6.

13.

In vitro inhibition of monkeypox virus production and spread by Interferon-β.

Johnston SC, Lin KL, Connor JH, Ruthel G, Goff A, Hensley LE.

Virol J. 2012 Jan 6;9:5. doi: 10.1186/1743-422X-9-5.

14.

Efficacy of a capsule conjugate vaccine against inhalational anthrax in rabbits and monkeys.

Chabot DJ, Joyce J, Caulfield M, Cook J, Hepler R, Wang S, Vietri NJ, Ruthel G, Shoop W, Pitt L, Leffel E, Ribot W, Friedlander AM.

Vaccine. 2012 Jan 20;30(5):846-52. doi: 10.1016/j.vaccine.2011.12.010. Epub 2011 Dec 13.

PMID:
22172509
15.

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors.

Ruthel G, Burnett JC, Nuss JE, Wanner LM, Tressler LE, Torres-Melendez E, Sandwick SJ, Retterer CJ, Bavari S.

Toxins (Basel). 2011 Mar;3(3):207-17. doi: 10.3390/toxins3030207. Epub 2011 Mar 15.

16.

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1.

Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR.

Nature. 2011 Aug 24;477(7364):340-3. doi: 10.1038/nature10348.

17.

A small molecule that mimics the BB-loop in the Toll interleukin-1 (IL-1) receptor domain of MyD88 attenuates staphylococcal enterotoxin B-induced pro-inflammatory cytokine production and toxicity in mice.

Kissner TL, Moisan L, Mann E, Alam S, Ruthel G, Ulrich RG, Rebek M, Rebek J Jr, Saikh KU.

J Biol Chem. 2011 Sep 9;286(36):31385-96. doi: 10.1074/jbc.M110.204982. Epub 2011 Jun 21.

18.

Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC class II molecules.

Kissner TL, Ruthel G, Alam S, Ulrich RG, Fernandez S, Saikh KU.

PLoS One. 2011 Jan 20;6(1):e15985. doi: 10.1371/journal.pone.0015985.

19.

Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.

Cardinale SC, Butler MM, Ruthel G, Nuss JE, Wanner LM, Li B, Pai R, Peet NP, Bavari S, Bowlin TL.

Botulinum J. 2011;2(1):16-29.

20.

Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease.

Nuss JE, Dong Y, Wanner LM, Ruthel G, Wipf P, Gussio R, Vennerstrom JL, Bavari S, Burnett JC.

ACS Med Chem Lett. 2010 Oct 14;1(7):301-305.

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