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Results: 1 to 20 of 144

1.

Efficacy and Safety of Tofacitinib as Monotherapy in Japanese Patients With Active Rheumatoid Arthritis: A 12-Week, Randomized, Phase 2 Study.

Tanaka Y, Takeuchi T, Yamanaka H, Nakamura H, Toyoizumi S, Zwillich S.

Mod Rheumatol. 2014 Dec 11:1-25. [Epub ahead of print]

PMID:
25496464
[PubMed - as supplied by publisher]
2.

Small-molecule therapeutics in rheumatoid arthritis: Scientific rationale, efficacy and safety.

Meier FM, McInnes IB.

Best Pract Res Clin Rheumatol. 2014 Aug;28(4):605-624. doi: 10.1016/j.berh.2014.10.017. Epub 2014 Nov 21. Review.

PMID:
25481553
[PubMed - as supplied by publisher]
3.

Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib.

Charles-Schoeman C, Fleischmann R, Davignon J, Schwartz H, Turner S, Beysen C, Milad M, Hellerstein M, Luo Z, Kaplan I, Riese R, Zuckerman A, McInnes IB.

Arthritis Rheumatol. 2014 Dec 2. doi: 10.1002/art.38974. [Epub ahead of print]

PMID:
25470338
[PubMed - as supplied by publisher]
4.

Small-molecule inhibitors of spleen tyrosine kinase as therapeutic agents for immune disorders: will promise meet expectations?

Lucas MC, Tan SL.

Future Med Chem. 2014 Oct;6(16):1811-27. doi: 10.4155/fmc.14.126.

PMID:
25407369
[PubMed - in process]
5.

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.

Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS.

Ann Rheum Dis. 2014 Nov 14. pii: annrheumdis-2014-206028. doi: 10.1136/annrheumdis-2014-206028. [Epub ahead of print]

PMID:
25398374
[PubMed - as supplied by publisher]
Free Article
6.

New treatments for inflammatory rheumatic disease.

Selmi C, Generali E, Massarotti M, Bianchi G, Sciré CA.

Immunol Res. 2014 Dec;60(2-3):277-88. doi: 10.1007/s12026-014-8565-5.

PMID:
25381481
[PubMed - in process]
7.

Lipid profile changes in patients with chronic inflammatory arthritis treated with biologics and tofacitinib in randomized clinical trials: A systematic review and meta-analysis.

Souto A, Salgado E, Maneiro JR, Mera A, Carmona L, Gómez-Reino JJ.

Arthritis Rheumatol. 2014 Oct 9. doi: 10.1002/art.38894. [Epub ahead of print]

PMID:
25303044
[PubMed - as supplied by publisher]
8.

Efficacy and safety of tofacitinib for treatment of rheumatoid arthritis.

Lundquist LM, Cole SW, Sikes ML.

World J Orthop. 2014 Sep 18;5(4):504-11. doi: 10.5312/wjo.v5.i4.504. eCollection 2014 Sep 18. Review.

PMID:
25232526
[PubMed]
Free PMC Article
9.

Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical perspectives.

Malemud CJ, Blumenthal DE.

World J Orthop. 2014 Sep 18;5(4):496-503. doi: 10.5312/wjo.v5.i4.496. eCollection 2014 Sep 18. Review.

PMID:
25232525
[PubMed]
Free PMC Article
10.

Tofacitinib versus methotrexate in rheumatoid arthritis.

Yuan K, Chen J, Xu A.

N Engl J Med. 2014 Sep 18;371(12):1163-4. doi: 10.1056/NEJMc1408607#SA2. No abstract available.

PMID:
25229928
[PubMed - indexed for MEDLINE]
11.

Tofacitinib versus methotrexate in rheumatoid arthritis.

Sexton D.

N Engl J Med. 2014 Sep 18;371(12):1163. doi: 10.1056/NEJMc1408607#SA1. No abstract available.

PMID:
25229927
[PubMed - indexed for MEDLINE]
12.

Tofacitinib versus methotrexate in rheumatoid arthritis.

Wilkinson B, Krishnaswami S, van Vollenhoven RF.

N Engl J Med. 2014 Sep 18;371(12):1164-5. doi: 10.1056/NEJMc1408607. No abstract available.

PMID:
25229926
[PubMed - indexed for MEDLINE]
Free Article
13.

Efficacy and safety of tofacitinib for active rheumatoid arthritis with an inadequate response to methotrexate or disease-modifying antirheumatic drugs: a meta-analysis of randomized controlled trials.

Song GG, Bae SC, Lee YH.

Korean J Intern Med. 2014 Sep;29(5):656-63. doi: 10.3904/kjim.2014.29.5.656. Epub 2014 Aug 28.

PMID:
25228842
[PubMed - in process]
Free PMC Article
14.

Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?

Kwok SK.

Korean J Intern Med. 2014 Sep;29(5):577-9. doi: 10.3904/kjim.2014.29.5.577. Epub 2014 Aug 28. No abstract available.

PMID:
25228832
[PubMed - in process]
Free PMC Article
15.

Selective inhibitors of the Janus kinase Jak3--Are they effective?

Thoma G, Drückes P, Zerwes HG.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4617-21. doi: 10.1016/j.bmcl.2014.08.046. Epub 2014 Aug 28.

PMID:
25217444
[PubMed - in process]
16.

Tofacitinib with methotrexate in third-line treatment of patients with active rheumatoid arthritis: Patient-reported outcomes from a Phase 3 trial.

Strand V, Burmester GR, Zerbini CA, Mebus CA, Zwillich SH, Gruben D, Wallenstein GV.

Arthritis Care Res (Hoboken). 2014 Sep 3. doi: 10.1002/acr.22453. [Epub ahead of print]

PMID:
25186034
[PubMed - as supplied by publisher]
17.

Update on Janus kinase antagonists in inflammatory bowel disease.

Boland BS, Sandborn WJ, Chang JT.

Gastroenterol Clin North Am. 2014 Sep;43(3):603-17. doi: 10.1016/j.gtc.2014.05.011. Epub 2014 Jun 24.

PMID:
25110261
[PubMed - in process]
18.

Changes in serum creatinine in patients with active rheumatoid arthritis treated with tofacitinib: results from clinical trials.

Isaacs JD, Zuckerman A, Krishnaswami S, Nduaka C, Lan S, Hutmacher MM, Boy MG, Kowalski K, Menon S, Riese R.

Arthritis Res Ther. 2014 Jul 25;16(4):R158. doi: 10.1186/ar4673.

PMID:
25063045
[PubMed - in process]
Free PMC Article
19.

Systematic review of tofacitinib: a new drug for the management of rheumatoid arthritis.

Kaur K, Kalra S, Kaushal S.

Clin Ther. 2014 Jul 1;36(7):1074-86. doi: 10.1016/j.clinthera.2014.06.018.

PMID:
25047498
[PubMed - in process]
20.

Analysis of infections and all-cause mortality in phase II, phase III, and long-term extension studies of tofacitinib in patients with rheumatoid arthritis.

Cohen S, Radominski SC, Gomez-Reino JJ, Wang L, Krishnaswami S, Wood SP, Soma K, Nduaka CI, Kwok K, Valdez H, Benda B, Riese R.

Arthritis Rheumatol. 2014 Nov;66(11):2924-37. doi: 10.1002/art.38779.

PMID:
25047021
[PubMed - in process]

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