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Page 1
Showing results for protonophore【地物】
Your search for protonosphere【地物】 retrieved no results
Short- and medium-chain fatty acids in energy metabolism: the cellular perspective.
Schönfeld P, Wojtczak L. Schönfeld P, et al. J Lipid Res. 2016 Jun;57(6):943-54. doi: 10.1194/jlr.R067629. Epub 2016 Apr 14. J Lipid Res. 2016. PMID: 27080715 Free PMC article. Review.
SCFAs and MCFAs modulate tissue metabolism of carbohydrates and lipids, as manifested by a mostly inhibitory effect on glycolysis and stimulation of lipogenesis or gluconeogenesis. SCFAs and MCFAs exert no or only weak protonophoric and lytic activities in mitochondria and …
SCFAs and MCFAs modulate tissue metabolism of carbohydrates and lipids, as manifested by a mostly inhibitory effect on glycolysis and stimul …
Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.
Bertholet AM, Natale AM, Bisignano P, Suzuki J, Fedorenko A, Hamilton J, Brustovetsky T, Kazak L, Garrity R, Chouchani ET, Brustovetsky N, Grabe M, Kirichok Y. Bertholet AM, et al. Nature. 2022 Jun;606(7912):180-187. doi: 10.1038/s41586-022-04747-5. Epub 2022 May 25. Nature. 2022. PMID: 35614225 Free PMC article.
As evidence of pharmacological activators of I(H) through UCP1 and AAC is lacking, I(H) is induced by protonophores such as 2,4-dinitrophenol (DNP) and cyanide-4-(trifluoromethoxy) phenylhydrazone (FCCP)(10,11). ...Here we report the direct measurement of I(H) induced by D …
As evidence of pharmacological activators of I(H) through UCP1 and AAC is lacking, I(H) is induced by protonophores such as 2,4-dinit …
Niclosamide: A career builder.
Needham D. Needham D. J Control Release. 2024 May;369:786-856. doi: 10.1016/j.jconrel.2023.07.016. Epub 2024 Mar 21. J Control Release. 2024. PMID: 37544514 Review.
To do this I take as my example, niclosamide, a small molecule protonophore that, uniquely, can "target" all cell membranes, both plasma and organelle. ...
To do this I take as my example, niclosamide, a small molecule protonophore that, uniquely, can "target" all cell membranes, both pla …
Longevity and mitochondrial membrane potential.
Knorre DA, Severin FF. Knorre DA, et al. Biochemistry (Mosc). 2012 Jul;77(7):793-4. doi: 10.1134/S0006297912070127. Biochemistry (Mosc). 2012. PMID: 22817543 Free article. Review.
In Saccharomyces cerevisiae yeast cells a decrease in the mitochondrial membrane potential caused by protonophores or by a loss of mitochondrial DNA leads to an increase in longevity (replicative life span). ...Together, it suggests that activation of selective mitophagy i …
In Saccharomyces cerevisiae yeast cells a decrease in the mitochondrial membrane potential caused by protonophores or by a loss of mi …
Anilinopyrazines as potential mitochondrial uncouplers.
Murray JH, Hargett S, Hoehn KL, Santos WL. Murray JH, et al. Bioorg Med Chem Lett. 2020 Apr 15;30(8):127057. doi: 10.1016/j.bmcl.2020.127057. Epub 2020 Feb 21. Bioorg Med Chem Lett. 2020. PMID: 32113842
Mitochondrial protonophores transport protons through the mitochondrial inner membrane into the matrix to uncouple nutrient oxidation from ATP production thereby decreasing the proton motive force. ...
Mitochondrial protonophores transport protons through the mitochondrial inner membrane into the matrix to uncouple nutrient oxidation …
How do uncoupling proteins uncouple?
Garlid KD, Jabůrek M, Jezek P, Varecha M. Garlid KD, et al. Biochim Biophys Acta. 2000 Aug 15;1459(2-3):383-9. doi: 10.1016/s0005-2728(00)00175-4. Biochim Biophys Acta. 2000. PMID: 11004454 Free article. Review.
According to the proton buffering model, introduced by Klingenberg, UCP1 conducts protons through a hydrophilic pathway lined with fatty acid head groups that buffer the protons as they move across the membrane. According to the fatty acid protonophore model, introduced by …
According to the proton buffering model, introduced by Klingenberg, UCP1 conducts protons through a hydrophilic pathway lined with fatty aci …
Mitochondria-Centric Review of Polyphenol Bioactivity in Cancer Models.
Stevens JF, Revel JS, Maier CS. Stevens JF, et al. Antioxid Redox Signal. 2018 Dec 1;29(16):1589-1611. doi: 10.1089/ars.2017.7404. Epub 2017 Dec 11. Antioxid Redox Signal. 2018. PMID: 29084444 Free PMC article. Review.
CRITICAL ISSUES: The ability of polyphenols to dissipate the MMP (deltapsi(m)) by a protonophore mechanism has been known for more than 50 years. However, researchers focus primarily on the downstream molecular effects of deltapsi(m) dissipation and mitochondrial uncouplin …
CRITICAL ISSUES: The ability of polyphenols to dissipate the MMP (deltapsi(m)) by a protonophore mechanism has been known for more th …
Energy conservation and uncoupling in mitochondria.
Hatefi Y. Hatefi Y. J Supramol Struct. 1975;3(3):201-13. doi: 10.1002/jss.400030302. J Supramol Struct. 1975. PMID: 1102805 Review.
(c) Trinitrophenol is a membrane-impermeable uncoupler (uncouples submitochondrial particles, but not mitochondria) and a poor protonophore. There is an excellent correlation between the uncoupling potencies and the affinities of uncouplers for the mitochondrial uncoupler- …
(c) Trinitrophenol is a membrane-impermeable uncoupler (uncouples submitochondrial particles, but not mitochondria) and a poor protonopho …
Uncouplers of oxidative phosphorylation.
Terada H. Terada H. Environ Health Perspect. 1990 Jul;87:213-8. doi: 10.1289/ehp.9087213. Environ Health Perspect. 1990. PMID: 2176586 Free PMC article. Review.
Weakly acidic uncouplers are considered to produce uncoupling by their protonophoric action in the H(+)-impermeable mitochondrial membrane. ...
Weakly acidic uncouplers are considered to produce uncoupling by their protonophoric action in the H(+)-impermeable mitochondrial mem …
1,581 results