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Page 1
Macrocyclic polyoxazoles as G-quadruplex ligands.
Iida K, Nagasawa K. Iida K, et al. Chem Rec. 2013 Dec;13(6):539-48. doi: 10.1002/tcr.201300015. Epub 2013 Nov 13. Chem Rec. 2013. PMID: 24347328 Review.
This review deals with recent progress in the synthesis and evaluation of our telomestatin-inspired macrocyclic polyoxazoles as G-quadruplex (G4) ligands. The hexaoxazole derivatives (6OTDs) interact with and stabilize G4-forming oligonucleotides, depending upon the charac …
This review deals with recent progress in the synthesis and evaluation of our telomestatin-inspired macrocyclic polyoxazoles as G-qua …
Macrocyclic pyridyl polyoxazoles: structure-activity studies of the aminoalkyl side-chain on G-quadruplex stabilization and cytotoxic activity.
Blankson G, Rzuczek SG, Bishop C, Pilch DS, Liu A, Liu L, Lavoie EJ, Rice JE. Blankson G, et al. Molecules. 2013 Sep 26;18(10):11938-63. doi: 10.3390/molecules181011938. Molecules. 2013. PMID: 24077174 Free PMC article.
Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. ...Here we detail the synthesis of eight new dimethylamino-substituted pyridyl polyoxazoles in which the point of attachment to the macrocycle, as well …
Pyridyl polyoxazoles are 24-membered macrocyclic lactams comprised of a pyridine, four oxazoles and a phenyl ring. ...Here we detail …
Retracted Article: Metal-free [2+2+1] cycloaddition polymerization of alkynes, nitriles, and oxygen atoms to functional polyoxazoles.
Dong L, Lan T, Liang Y, Guo S, Zhang H. Dong L, et al. RSC Adv. 2020 Jun 25;10(41):24368-24373. doi: 10.1039/d0ra04249h. eCollection 2020 Jun 24. RSC Adv. 2020. PMID: 35516187 Free PMC article. Retracted.
The present reaction could be applied to a facile synthesis of polyoxazoles. In this work, the cycloaddition polymerization of 4-cyano-4'-ethynylbiphenyl and PhIO was developed and modified polyoxazole was prepared. ...In addition, the good thermal stability of p …
The present reaction could be applied to a facile synthesis of polyoxazoles. In this work, the cycloaddition polymerization of 4-cyan …
Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.
Rzuczek SG, Pilch DS, Liu A, Liu L, LaVoie EJ, Rice JE. Rzuczek SG, et al. J Med Chem. 2010 May 13;53(9):3632-44. doi: 10.1021/jm1000612. J Med Chem. 2010. PMID: 20359224 Free PMC article.
The synthesis of a series of 24-membered pyridine-containing polyoxazole macrocycles is described. Seventeen new macrocycles were evaluated for cytotoxic activity against RPMI 8402, KB-3, and KB-3 cell lines that overexpress the efflux transporters MDR1 (KBV-1) and BCRP (K …
The synthesis of a series of 24-membered pyridine-containing polyoxazole macrocycles is described. Seventeen new macrocycles were eva …
Oxadiazole/Pyridine-Based Ligands: A Structural Tuning for Enhancing G-Quadruplex Binding.
Doria F, Pirota V, Petenzi M, Teulade-Fichou MP, Verga D, Freccero M. Doria F, et al. Molecules. 2018 Aug 28;23(9):2162. doi: 10.3390/molecules23092162. Molecules. 2018. PMID: 30154319 Free PMC article.
Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl polyoxazoles and polyoxadiazoles were recently identified as selective G-quadruplex stabilizing compounds with high cytotoxicity and prom …
Non-macrocyclic heteroaryls represent a valuable class of ligands for nucleic acid recognition. In this regard, non-macrocyclic pyridyl p …
Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity.
Blankson GA, Pilch DS, Liu AA, Liu LF, Rice JE, LaVoie EJ. Blankson GA, et al. Bioorg Med Chem. 2013 Aug 1;21(15):4511-20. doi: 10.1016/j.bmc.2013.05.033. Epub 2013 May 30. Bioorg Med Chem. 2013. PMID: 23787291 Free PMC article.
These biphenyl tetraoxazoles were not strong ligands for G-quadruplex DNA relative to other macrocyclic polyoxazoles. This reduced stabilizing potential did correlate with their comparatively lower cytotoxic activity as observed in the human tumor cell lines, RPMI 8402 and …
These biphenyl tetraoxazoles were not strong ligands for G-quadruplex DNA relative to other macrocyclic polyoxazoles. This reduced st …
Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B.
Mattila A, Andsten RM, Jumppanen M, Assante M, Jokela J, Wahlsten M, Mikula KM, Sigindere C, Kwak DH, Gugger M, Koskela H, Sivonen K, Liu X, Yli-Kauhaluoma J, Iwaï H, Fewer DP. Mattila A, et al. ACS Chem Biol. 2019 Dec 20;14(12):2683-2690. doi: 10.1021/acschembio.9b00620. Epub 2019 Nov 19. ACS Chem Biol. 2019. PMID: 31674754
This finding expands the regiospecific chemical functionality of cyanobactin prenyltransferases and the chemical diversity of the cyanobactin family of natural products to include bis-prenylated polyoxazole linear peptides....
This finding expands the regiospecific chemical functionality of cyanobactin prenyltransferases and the chemical diversity of the cyanobacti …
19 results