Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 3
2000 1
2001 3
2002 5
2003 9
2004 4
2005 8
2006 16
2007 12
2008 5
2009 9
2010 9
2011 14
2012 17
2013 20
2014 15
2015 11
2016 9
2017 8
2018 15
2019 11
2020 12
2021 10
2022 6
2023 9
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

220 results

Results by year

Filters applied: . Clear all
Page 1
Pin1 and Alzheimer's disease.
Malter JS. Malter JS. Transl Res. 2023 Apr;254:24-33. doi: 10.1016/j.trsl.2022.09.003. Epub 2022 Sep 23. Transl Res. 2023. PMID: 36162703 Free PMC article. Review.
Alzheimer's disease (AD) is an immense and growing public health crisis. ...Here I review the functionality of Pin1 and its role in neurodegeneration....
Alzheimer's disease (AD) is an immense and growing public health crisis. ...Here I review the functionality of Pin1
Peptidyl-Prolyl Cis/Trans Isomerase Pin1 and Alzheimer's Disease.
Wang L, Zhou Y, Chen D, Lee TH. Wang L, et al. Front Cell Dev Biol. 2020 May 15;8:355. doi: 10.3389/fcell.2020.00355. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32500074 Free PMC article. Review.
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. ...Although Pin1 is tightly regulated under physiological conditions, Pin1 deregulation in the brain contributes to the development of neurodegenerative diseas
Alzheimer's disease (AD) is the most common cause of dementia with cognitive decline. ...Although Pin1 is tightl
Pin1 in Alzheimer's disease.
Butterfield DA, Abdul HM, Opii W, Newman SF, Joshi G, Ansari MA, Sultana R. Butterfield DA, et al. J Neurochem. 2006 Sep;98(6):1697-706. doi: 10.1111/j.1471-4159.2006.03995.x. J Neurochem. 2006. PMID: 16945100 Free article. Review.
Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to be increased in Alzheimer's disease (AD) brains, leading to increased production of beta-amyloid (Abeta) peptides and ne …
Proteolytic processing and phosphorylation of amyloid precursor protein (APP), and hyperphosphorylation of tau protein, have been shown to b …
Pin1 flips Alzheimer's switch.
Etzkorn FA. Etzkorn FA. ACS Chem Biol. 2006 May 23;1(4):214-6. doi: 10.1021/cb600171g. ACS Chem Biol. 2006. PMID: 17163675 Review.
The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a peptidyl-prolyl isomerase, Pin1, specifically regulates the degradation of amyloid precursor protein (APP). An alternative model for …
The biochemical processes leading to Alzheimer's disease are just now being elucidated. A recent study shows that a pep …
Pin1: a new genetic link between Alzheimer's disease, cancer and aging.
Driver JA, Lu KP. Driver JA, et al. Curr Aging Sci. 2010 Dec;3(3):158-65. doi: 10.2174/1874609811003030158. Curr Aging Sci. 2010. PMID: 20735350 Review.
The loss of active Pin1 leads to the accumulation of abnormal tau and the overproduction of beta-amyloid, the cardinal features of Alzheimer's disease. ...We hypothesize that Pin1 might help explain an inverse relationship between Alzheimer
The loss of active Pin1 leads to the accumulation of abnormal tau and the overproduction of beta-amyloid, the cardinal features of …
Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?
Balastik M, Lim J, Pastorino L, Lu KP. Balastik M, et al. Biochim Biophys Acta. 2007 Apr;1772(4):422-9. doi: 10.1016/j.bbadis.2007.01.006. Epub 2007 Jan 23. Biochim Biophys Acta. 2007. PMID: 17317113 Free PMC article. Review.
Presence of neuritic plaques and neurofibrillary tangles in the brain are two neuropathological hallmarks of Alzheimer's disease (AD), although the molecular basis of their coexistence remains elusive. ...Furthermore, Pin1 is the only gene known so far …
Presence of neuritic plaques and neurofibrillary tangles in the brain are two neuropathological hallmarks of Alzheimer's di
Pin1: a new outlook in Alzheimer's disease.
Lonati E, Masserini M, Bulbarelli A. Lonati E, et al. Curr Alzheimer Res. 2011 Sep;8(6):615-22. doi: 10.2174/156720511796717140. Curr Alzheimer Res. 2011. PMID: 21605045 Review.
Neurodegenerative diseases termed Tauopathies, including Alzheimer disease, are characterized by the presence of intraneuronal neurofibrillary tangles (NFTs), composed by hyperphosphorylated protein Tau. ...However, Pin1 activity in Tauopathies in which Tau i …
Neurodegenerative diseases termed Tauopathies, including Alzheimer disease, are characterized by the presence of intraneuronal …
Melatonin regulates Abeta production/clearance balance and Abeta neurotoxicity: A potential therapeutic molecule for Alzheimer's disease.
Li Y, Zhang J, Wan J, Liu A, Sun J. Li Y, et al. Biomed Pharmacother. 2020 Dec;132:110887. doi: 10.1016/j.biopha.2020.110887. Epub 2020 Nov 2. Biomed Pharmacother. 2020. PMID: 33254429 Free article. Review.
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple predisposing factors and complicated pathogenesis. ...
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple predisposing factors and comp
Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease.
Driver JA, Zhou XZ, Lu KP. Driver JA, et al. Biochim Biophys Acta. 2015 Oct;1850(10):2069-76. doi: 10.1016/j.bbagen.2014.12.025. Epub 2015 Jan 10. Biochim Biophys Acta. 2015. PMID: 25583562 Free PMC article. Review.
BACKGROUND: Pin1 is an intracellular signaling molecule which plays a critical but opposite role in the pathogenesis of Alzheimer's disease (AD) and many human cancers. ...Inhibition of Pin1 in animal models has profound anti-tumor effects. In c …
BACKGROUND: Pin1 is an intracellular signaling molecule which plays a critical but opposite role in the pathogenesis of Alzheimer
Regulation of protein conformation by Pin1 offers novel disease mechanisms and therapeutic approaches in Alzheimer's disease.
Driver JA, Zhou XZ, Lu KP. Driver JA, et al. Discov Med. 2014 Feb;17(92):93-9. Discov Med. 2014. PMID: 24534472 Free PMC article. Review.
This change in shape has profound effects on protein function and is a major signaling mechanism in the cell. Abnormal regulation of Pin1 has been associated with premature aging and multiple pathological processes, notably cancer and Alzheimer's disease
This change in shape has profound effects on protein function and is a major signaling mechanism in the cell. Abnormal regulation of Pin1
220 results