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Anticancer effects of Pimaric acid is mediated via endoplasmic reticulum stress, caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration in human ovarian cancer cells.
Li W, Xuemei G, Yilin Z, Han W, Yajun H, Yi H, Zhongxiang Z. Li W, et al. Acta Biochim Pol. 2022 Mar 2;69(1):245-250. doi: 10.18388/abp.2020_6011. Acta Biochim Pol. 2022. PMID: 35231164 Free article.
Pimaric acid is a naturally occurring resin and has been found to perform many pharmacological activities including, anticancer activity. However, the role of Pimaric acid in ovarian cancer is still not known. This investigation aimed to evaluate the a
Pimaric acid is a naturally occurring resin and has been found to perform many pharmacological activities including, anticance
Pimaric acid reduces vasoconstriction via BK(Ca) channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
Ishida M, Yamamura A, Fujiwara M, Amano T, Ota M, Hikawa Y, Kondo R, Suzuki Y, Imaizumi Y, Yamamura H. Ishida M, et al. J Pharmacol Sci. 2023 Oct;153(2):84-88. doi: 10.1016/j.jphs.2023.08.001. Epub 2023 Aug 10. J Pharmacol Sci. 2023. PMID: 37640473 Free article.
Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated large-conductance Ca(2+)-activated K(+) (BK(Ca)) channels and inhibited voltage-dependent Ca(2+) channels (VDCCs). ...
Pulmonary vessels play a pivotal role in oxygen circulation. We previously demonstrated that pimaric acid (PiMA) activated lar …
Molecular mechanisms underlying pimaric acid-induced modulation of voltage-gated K(+) channels.
Sakamoto K, Suzuki Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y. Sakamoto K, et al. J Pharmacol Sci. 2017 Apr;133(4):223-231. doi: 10.1016/j.jphs.2017.02.013. Epub 2017 Mar 8. J Pharmacol Sci. 2017. PMID: 28391996 Free article.
Voltage-gated K(+) (K(V)) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential therapeutic targets in many types of diseases. Pimaric acid (PiMA) is a unique opener of large conductance Ca(2+)-activated K(+) …
Voltage-gated K(+) (K(V)) channels, which control firing and shape of action potentials in excitable cells, are supposed to be potential the …
Pimaric acid from Aralia cordata has an inhibitory effect on TNF-alpha-induced MMP-9 production and HASMC migration via down-regulated NF-kappaB and AP-1.
Suh SJ, Kwak CH, Chung TW, Park SJ, Cheeeei M, Park SS, Seo CS, Son JK, Chang YC, Park YG, Lee YC, Chang HW, Kim CH. Suh SJ, et al. Chem Biol Interact. 2012 Aug 30;199(2):112-9. doi: 10.1016/j.cbi.2012.06.003. Epub 2012 Jun 13. Chem Biol Interact. 2012. PMID: 22705379
Many studies have indicated that activation of matrix metalloproteinase (MMP)-9 and smooth muscle cell (SMC) migration are involved in neointimal formation and atherosclerosis. In this study, we revealed that pimaric acid (PiMA) purified from Aralia cordata had an i …
Many studies have indicated that activation of matrix metalloproteinase (MMP)-9 and smooth muscle cell (SMC) migration are involved in neoin …
4-epi-Pimaric acid: a phytomolecule as a potent antibacterial and anti-biofilm agent for oral cavity pathogens.
Ali F, Sangwan PL, Koul S, Pandey A, Bani S, Abdullah ST, Sharma PR, Kitchlu S, Khan IA. Ali F, et al. Eur J Clin Microbiol Infect Dis. 2012 Feb;31(2):149-59. doi: 10.1007/s10096-011-1287-x. Epub 2011 May 19. Eur J Clin Microbiol Infect Dis. 2012. PMID: 21594714
The present study focused on the antibacterial and biofilm inhibitory potential of 4-epi-pimaric acid isolated from aerial parts (stem and leaves) of Aralia cachemirica L. (Araliaceae) against oral cavity pathogens. 4-epi-Pimaric acid exhibited minimum …
The present study focused on the antibacterial and biofilm inhibitory potential of 4-epi-pimaric acid isolated from aerial par …
Retinoic acid receptor agonist activity of naturally occurring diterpenes.
Tanabe H, Yasui T, Kotani H, Nagatsu A, Makishima M, Amagaya S, Inoue M. Tanabe H, et al. Bioorg Med Chem. 2014 Jun 15;22(12):3204-12. doi: 10.1016/j.bmc.2014.03.047. Epub 2014 Apr 13. Bioorg Med Chem. 2014. PMID: 24799257
Pimaradienoic acid (ent-pimara-8(14),15-dien-19-oic acid) was subsequently isolated as the constituent capable of activating RAR. Pimaric acid and abietic acid, which have similar structures to pimaradienoic acid, were also found to be novel RAR agonists, although a …
Pimaradienoic acid (ent-pimara-8(14),15-dien-19-oic acid) was subsequently isolated as the constituent capable of activating RAR. Pimaric
1,4a,7-Trimethyl-7-vinyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodeca-hydro-phenanthrene-1-carboxylic acid.
Chen YX, Zhao ZD, Gu Y, Wang YM. Chen YX, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Apr 25;65(Pt 5):o1117. doi: 10.1107/S1600536809013233. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21583929 Free PMC article.
The title compound, pimaric acid, C(20)H(30)O(2), was isolated from a mixture of resin acids. ...
The title compound, pimaric acid, C(20)H(30)O(2), was isolated from a mixture of resin acids. ...
Recent developments and future prospects on bio-based polyesters derived from renewable resources: A review.
Zia KM, Noreen A, Zuber M, Tabasum S, Mujahid M. Zia KM, et al. Int J Biol Macromol. 2016 Jan;82:1028-40. doi: 10.1016/j.ijbiomac.2015.10.040. Epub 2015 Oct 19. Int J Biol Macromol. 2016. PMID: 26492854 Review.
Isosorbide, 2,4:3,5-di-O-methylene-d-mannitol, bicyclic diacetalyzed galactaric acid, 2,5-furandicarboxylic acid, citric, 2,3-O-methylene l-threitol, dimethyl 2,3-O-methylene l-threarate, betulin, dihydrocarvone, decalactone, pimaric acid, ricinoleic acid and sebaci …
Isosorbide, 2,4:3,5-di-O-methylene-d-mannitol, bicyclic diacetalyzed galactaric acid, 2,5-furandicarboxylic acid, citric, 2,3-O-methylene l- …
Terpenoid Compositions of Resins from Callitris Species (Cupressaceae).
Simoneit BRT, Cox RE, Oros DR, Otto A. Simoneit BRT, et al. Molecules. 2018 Dec 19;23(12):3384. doi: 10.3390/molecules23123384. Molecules. 2018. PMID: 30572688 Free PMC article.
Phenolic diterpenoids, for example, ferruginol, hinokiol, were found in trace quantities in some samples. Thus, callitrisic acid and 4-epi-pimaric acid are the characteristic diterpenoids of Callitris species that are amenable to molecular biomarker analyses in geol …
Phenolic diterpenoids, for example, ferruginol, hinokiol, were found in trace quantities in some samples. Thus, callitrisic acid and 4-epi- …
64 results