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Items: 1 to 20 of 99

1.

Mapping of the Allosteric Site in Cholesterol Hydroxylase CYP46A1 for Efavirenz, a Drug That Stimulates Enzyme Activity.

Anderson KW, Mast N, Hudgens JW, Lin JB, Turko IV, Pikuleva IA.

J Biol Chem. 2016 May 27;291(22):11876-86. doi: 10.1074/jbc.M116.723577. Epub 2016 Apr 7.

PMID:
27056331
2.

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis.

Lin JB, Mast N, Bederman IR, Li Y, Brunengraber H, Björkhem I, Pikuleva IA.

J Lipid Res. 2016 Feb;57(2):258-64. doi: 10.1194/jlr.M064469. Epub 2015 Dec 2.

PMID:
26630912
3.

Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols.

van Lier JE, Mast N, Pikuleva IA.

Angew Chem Int Ed Engl. 2015 Sep 14;54(38):11138-42. doi: 10.1002/anie.201505002. Epub 2015 Jul 29.

PMID:
26230055
4.

Histone H3 Ser57 and Thr58 phosphorylation in the brain of 5XFAD mice.

Anderson KW, Mast N, Pikuleva IA, Turko IV.

FEBS Open Bio. 2015 Jun 25;5:550-6. doi: 10.1016/j.fob.2015.06.009. eCollection 2015.

5.

Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.

Mast N, Lin JB, Pikuleva IA.

Mol Pharmacol. 2015 Sep;88(3):428-36. doi: 10.1124/mol.115.099598. Epub 2015 Jun 16.

PMID:
26082378
6.

Quantification of histone deacetylase isoforms in human frontal cortex, human retina, and mouse brain.

Anderson KW, Chen J, Wang M, Mast N, Pikuleva IA, Turko IV.

PLoS One. 2015 May 11;10(5):e0126592. doi: 10.1371/journal.pone.0126592. eCollection 2015.

7.

Mass spectrometry detection of isolevuglandin adduction to specific protein residues.

Charvet CD, Pikuleva IA.

Methods Mol Biol. 2015;1208:285-98. doi: 10.1007/978-1-4939-1441-8_21.

8.

Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments.

Zheng W, Mast N, Saadane A, Pikuleva IA.

J Lipid Res. 2015 Jan;56(1):81-97. doi: 10.1194/jlr.M053439. Epub 2014 Oct 7.

9.

Retinal and nonocular abnormalities in Cyp27a1(-/-)Cyp46a1(-/-) mice with dysfunctional metabolism of cholesterol.

Saadane A, Mast N, Charvet CD, Omarova S, Zheng W, Huang SS, Kern TS, Peachey NS, Pikuleva IA.

Am J Pathol. 2014 Sep;184(9):2403-19. doi: 10.1016/j.ajpath.2014.05.024. Epub 2014 Jul 25.

10.

Effects of a disrupted blood-brain barrier on cholesterol homeostasis in the brain.

Saeed AA, Genové G, Li T, Lütjohann D, Olin M, Mast N, Pikuleva IA, Crick P, Wang Y, Griffiths W, Betsholtz C, Björkhem I.

J Biol Chem. 2014 Aug 22;289(34):23712-22. doi: 10.1074/jbc.M114.556159. Epub 2014 Jun 27.

11.

Cholesterol in the retina: the best is yet to come.

Pikuleva IA, Curcio CA.

Prog Retin Eye Res. 2014 Jul;41:64-89. doi: 10.1016/j.preteyeres.2014.03.002. Epub 2014 Apr 4. Review.

12.

Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice.

Mast N, Li Y, Linger M, Clark M, Wiseman J, Pikuleva IA.

J Biol Chem. 2014 Feb 7;289(6):3529-38. doi: 10.1074/jbc.M113.532846. Epub 2013 Dec 18.

13.

7α-hydroxy-3-oxo-4-cholestenoic acid in cerebrospinal fluid reflects the integrity of the blood-brain barrier.

Saeed A, Floris F, Andersson U, Pikuleva I, Lövgren-Sandblom A, Bjerke M, Paucar M, Wallin A, Svenningsson P, Björkhem I.

J Lipid Res. 2014 Feb;55(2):313-8. doi: 10.1194/jlr.P044982. Epub 2013 Dec 8.

14.

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Charvet CD, Saadane A, Wang M, Salomon RG, Brunengraber H, Turko IV, Pikuleva IA.

J Biol Chem. 2013 Oct 11;288(41):29267-80. doi: 10.1074/jbc.M113.498832. Epub 2013 Aug 22. Erratum in: J Biol Chem. 2013 Nov 22;288(47):34054. Dosage error in article text.

15.

Mass spectrometry quantification of PICALM and AP180 in human frontal cortex and neural retina.

Chen J, Pikuleva IA, Turko IV.

Anal Biochem. 2013 Nov 15;442(2):253-8. doi: 10.1016/j.ab.2013.08.005. Epub 2013 Aug 13.

16.

Cytochromes p450: roles in diseases.

Pikuleva IA, Waterman MR.

J Biol Chem. 2013 Jun 14;288(24):17091-8. doi: 10.1074/jbc.R112.431916. Epub 2013 Apr 30. Review.

17.

Antifungal Azoles: Structural Insights into Undesired Tight Binding to Cholesterol-Metabolizing CYP46A1.

Mast N, Zheng W, Stout CD, Pikuleva IA.

Mol Pharmacol. 2013 Jul;84(1):86-94. doi: 10.1124/mol.113.085902. Epub 2013 Apr 19.

18.

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1.

Charvet CD, Laird J, Xu Y, Salomon RG, Pikuleva IA.

J Lipid Res. 2013 May;54(5):1421-9. doi: 10.1194/jlr.M035790. Epub 2013 Mar 11.

19.

Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response.

Mast N, Zheng W, Stout CD, Pikuleva IA.

J Biol Chem. 2013 Feb 15;288(7):4613-24. doi: 10.1074/jbc.M112.438754. Epub 2013 Jan 3.

20.

Inhibition and stimulation of activity of purified recombinant CYP11A1 by therapeutic agents.

Mast N, Linger M, Pikuleva IA.

Mol Cell Endocrinol. 2013 May 22;371(1-2):100-6. doi: 10.1016/j.mce.2012.10.013. Epub 2012 Oct 23.

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