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29 results

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Page 1
Tyrosine dephosphorylation underlies DHPG-induced LTD.
Moult PR, Schnabel R, Kilpatrick IC, Bashir ZI, Collingridge GL. Moult PR, et al. Neuropharmacology. 2002 Aug;43(2):175-80. doi: 10.1016/s0028-3908(02)00110-7. Neuropharmacology. 2002. PMID: 12213271
In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 microM phenyl-arsine oxide) significantly inhibited DHPG-induced LTD. These data suggest that DHPG-induced LTD involves activation of a protein tyrosine phosphatase....
In contrast two protein tyrosine phosphatase (PTP) inhibitors (1 mM orthovanadate or 15 microM phenyl-arsine oxide) sig …
Phosphatidylinositol Monophosphates Regulate the Membrane Localization of HSPA1A, a Stress-Inducible 70-kDa Heat Shock Protein.
Smulders L, Altman R, Briseno C, Saatchi A, Wallace L, AlSebaye M, Stahelin RV, Nikolaidis N. Smulders L, et al. Biomolecules. 2022 Jun 20;12(6):856. doi: 10.3390/biom12060856. Biomolecules. 2022. PMID: 35740982 Free PMC article.
Next, we manipulated the cellular lipid content using ionomycin, phenyl arsine oxide (PAO), GSK-A1, and wortmannin. These experiments revealed that HSPA1A's PM localization was unaffected by ionomycin but was significantly reduced by PAO, GSK-A1, and wortmann …
Next, we manipulated the cellular lipid content using ionomycin, phenyl arsine oxide (PAO), GSK-A1, and wortmannin. The …
An improved synthesis of arsenic-biotin conjugates.
Heredia-Moya J, Kirk KL. Heredia-Moya J, et al. Bioorg Med Chem. 2008 May 15;16(10):5743-6. doi: 10.1016/j.bmc.2008.03.054. Epub 2008 Mar 27. Bioorg Med Chem. 2008. PMID: 18396406 Free PMC article.
An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of biotinyl chloride, formed in situ, with p-aminophenyldichloroarsine. The reaction of the arsine oxide-biotin conjugate with 1, …
An amide linked conjugate of p-aminophenylarsine oxide and biotin is conveniently prepared in a one-pot procedure by the reaction of …
Cutaneous Exposure to Arsenicals Is Associated with Development of Constrictive Bronchiolitis in Mice.
Surolia R, Li FJ, Dsouza K, Zeng H, Singh P, Stephens C, Guo Y, Wang Z, Kashyap M, Srivastava R, Lora Gonzalez M, Benson P, Kumar A, Kim H, Kim YI, Ahmad A, Athar M, Antony VB. Surolia R, et al. Am J Respir Cell Mol Biol. 2023 May;68(5):485-497. doi: 10.1165/rcmb.2022-0321MA. Am J Respir Cell Mol Biol. 2023. PMID: 36780670 Free PMC article.
We exposed mice to lewisite, DPCA, or a less toxic surrogate organoarsenic chemical, phenyl arsine oxide, on the skin. The surviving mice were followed for 20 weeks after skin exposure to arsenicals. ...
We exposed mice to lewisite, DPCA, or a less toxic surrogate organoarsenic chemical, phenyl arsine oxide, on the skin. …
Active site targeting of hedgehog precursor protein with phenylarsine oxide.
Owen TS, Xie XJ, Laraway B, Ngoje G, Wang C, Callahan BP. Owen TS, et al. Chembiochem. 2015 Jan 2;16(1):55-8. doi: 10.1002/cbic.201402421. Epub 2014 Nov 21. Chembiochem. 2015. PMID: 25418613 Free PMC article.
Hedgehog proteins, signaling molecules implicated in human embryo development and cancer, can be inhibited at the stage of autoprocessing by the trivalent arsenical phenyl arsine oxide (PhAs(III) ). The interaction (apparent Ki , 4 10(-7) M) is characterized …
Hedgehog proteins, signaling molecules implicated in human embryo development and cancer, can be inhibited at the stage of autoprocessing by …
The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.
Zsengellér ZK, Gerard NP. Zsengellér ZK, et al. Immunobiology. 2020 Mar;225(2):151895. doi: 10.1016/j.imbio.2019.12.004. Epub 2019 Dec 5. Immunobiology. 2020. PMID: 31843260
Here we seek to determine the molecular mechanism by which TLR2 and TLR4, members of the Toll-like receptor family, are activated by bacterial LPS, hyperoxia, and zymosan respectively. Our central hypothesis is that the oxidation state of cysteine thiols on the ectodomain …
Here we seek to determine the molecular mechanism by which TLR2 and TLR4, members of the Toll-like receptor family, are activated by bacteri …
Mitochondrial free [Ca2+] levels and the permeability transition.
Vay L, Hernández-SanMiguel E, Lobatón CD, Moreno A, Montero M, Alvarez J. Vay L, et al. Cell Calcium. 2009 Mar;45(3):243-50. doi: 10.1016/j.ceca.2008.10.007. Epub 2008 Dec 18. Cell Calcium. 2009. PMID: 19100620
In addition, this high [Ca(2+)](M) did not induce PTP opening unless additional activators (phenyl arsine oxide, PAO) were present. PAO induced a rapid, concentration-dependent and irreversible drop in [Ca(2+)](M). ...
In addition, this high [Ca(2+)](M) did not induce PTP opening unless additional activators (phenyl arsine oxide, PAO) w …
29 results