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Items: 1 to 20 of 89


Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators.

Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG.

J Med Chem. 2015 Dec 24;58(24):9498-509. doi: 10.1021/acs.jmedchem.5b00929. Epub 2015 Dec 9.


Cutaneous penetration of the topically applied photosensitizer Pc 4 as detected by intravital 2-photon laser scanning microscopy.

Huang AY, Myers JT, Barkauskas D, Howell SJ, Oleinick NL, McCormick TS, Cooper KD, Baron ED, Lam M.

Photodiagnosis Photodyn Ther. 2012 Sep;9(3):225-31. doi: 10.1016/j.pdpdt.2012.01.007. Epub 2012 Feb 23.


Optimization of a nanomedicine-based silicon phthalocyanine 4 photodynamic therapy (Pc 4-PDT) strategy for targeted treatment of EGFR-overexpressing cancers.

Master AM, Livingston M, Oleinick NL, Sen Gupta A.

Mol Pharm. 2012 Aug 6;9(8):2331-8. doi: 10.1021/mp300256e. Epub 2012 Jul 19.


EGFR-mediated intracellular delivery of Pc 4 nanoformulation for targeted photodynamic therapy of cancer: in vitro studies.

Master AM, Qi Y, Oleinick NL, Gupta AS.

Nanomedicine. 2012 Jul;8(5):655-64. doi: 10.1016/j.nano.2011.09.012. Epub 2011 Oct 22.


Successful cutaneous delivery of the photosensitizer silicon phthalocyanine 4 for photodynamic therapy.

Lam M, Hsia AH, Liu Y, Guo M, Swick AR, Berlin JC, McCormick TS, Kenney ME, Oleinick NL, Cooper KD, Baron ED.

Clin Exp Dermatol. 2011 Aug;36(6):645-51. doi: 10.1111/j.1365-2230.2010.03989.x. Epub 2011 May 30. Review.


Photodynamic therapy with Pc 4 induces apoptosis of Candida albicans.

Lam M, Jou PC, Lattif AA, Lee Y, Malbasa CL, Mukherjee PK, Oleinick NL, Ghannoum MA, Cooper KD, Baron ED.

Photochem Photobiol. 2011 Jul-Aug;87(4):904-9. doi: 10.1111/j.1751-1097.2011.00938.x. Epub 2011 Jun 13.


Radiosensitization of human cervical cancer cells by inhibiting ribonucleotide reductase: enhanced radiation response at low-dose rates.

Kunos CA, Colussi VC, Pink J, Radivoyevitch T, Oleinick NL.

Int J Radiat Oncol Biol Phys. 2011 Jul 15;80(4):1198-204. doi: 10.1016/j.ijrobp.2011.01.034. Epub 2011 Apr 4.


Silicon phthalocyanine (Pc 4) photodynamic therapy is a safe modality for cutaneous neoplasms: results of a phase 1 clinical trial.

Baron ED, Malbasa CL, Santo-Domingo D, Fu P, Miller JD, Hanneman KK, Hsia AH, Oleinick NL, Colussi VC, Cooper KD.

Lasers Surg Med. 2010 Dec;42(10):728-35. doi: 10.1002/lsm.20984.


Photodynamic therapy with the silicon phthalocyanine pc 4 induces apoptosis in mycosis fungoides and sezary syndrome.

Lam M, Lee Y, Deng M, Hsia AH, Morrissey KA, Yan C, Azzizudin K, Oleinick NL, McCormick TS, Cooper KD, Baron ED.

Adv Hematol. 2010;2010:896161. doi: 10.1155/2010/896161. Epub 2010 Dec 12.


Preliminary clinical and pharmacologic investigation of photodynamic therapy with the silicon phthalocyanine photosensitizer pc 4 for primary or metastatic cutaneous cancers.

Kinsella TJ, Baron ED, Colussi VC, Cooper KD, Hoppel CL, Ingalls ST, Kenney ME, Li X, Oleinick NL, Stevens SR, Remick SC.

Front Oncol. 2011 Jun 30;1:14. doi: 10.3389/fonc.2011.00014. eCollection 2011.


Binding to and photo-oxidation of cardiolipin by the phthalocyanine photosensitizer Pc 4.

Rodriguez ME, Kim J, Delos Santos GB, Azizuddin K, Berlin J, Anderson VE, Kenney ME, Oleinick NL.

J Biomed Opt. 2010 Sep-Oct;15(5):051604. doi: 10.1117/1.3484256.


A requirement for bid for induction of apoptosis by photodynamic therapy with a lysosome- but not a mitochondrion-targeted photosensitizer.

Chiu SM, Xue LY, Lam M, Rodriguez ME, Zhang P, Kenney ME, Nieminen AL, Oleinick NL.

Photochem Photobiol. 2010 Sep-Oct;86(5):1161-73. doi: 10.1111/j.1751-1097.2010.00766.x.


Photo-oxidation of cardiolipin and cytochrome c with bilayer-embedded Pc 4.

Kim J, Rodriguez ME, Oleinick NL, Anderson VE.

Free Radic Biol Med. 2010 Sep 1;49(5):718-25. doi: 10.1016/j.freeradbiomed.2010.05.014. Epub 2010 May 25.


Photosensitization of intact heart mitochondria by the phthalocyanine Pc 4: Correlation of structural and functional deficits with cytochrome c release.

Kim J, Fujioka H, Oleinick NL, Anderson VE.

Free Radic Biol Med. 2010 Sep 1;49(5):726-32. doi: 10.1016/j.freeradbiomed.2010.05.013. Epub 2010 May 25.


Photodynamic therapy of cottontail rabbit papillomavirus-induced papillomas in a severe combined immunodeficient mouse xenograft system.

Lee RG, Vecchiotti MA, Heaphy J, Panneerselvam A, Schluchter MD, Oleinick NL, Lavertu P, Alagramam KN, Arnold JE, Sprecher RC.

Laryngoscope. 2010 Mar;120(3):618-24. doi: 10.1002/lary.20709.


Atg7 deficiency increases resistance of MCF-7 human breast cancer cells to photodynamic therapy.

Xue LY, Chiu SM, Oleinick NL.

Autophagy. 2010 Feb;6(2):248-55. Epub 2010 Mar 2.


Delivery of the photosensitizer Pc 4 in PEG-PCL micelles for in vitro PDT studies.

Master AM, Rodriguez ME, Kenney ME, Oleinick NL, Gupta AS.

J Pharm Sci. 2010 May;99(5):2386-98. doi: 10.1002/jps.22007.


Structural factors and mechanisms underlying the improved photodynamic cell killing with silicon phthalocyanine photosensitizers directed to lysosomes versus mitochondria.

Rodriguez ME, Zhang P, Azizuddin K, Delos Santos GB, Chiu SM, Xue LY, Berlin JC, Peng X, Wu H, Lam M, Nieminen AL, Kenney ME, Oleinick NL.

Photochem Photobiol. 2009 Sep-Oct;85(5):1189-200. doi: 10.1111/j.1751-1097.2009.00558.x. Epub 2009 Apr 6.


Targeting of mitochondria by 10-N-alkyl acridine orange analogues: role of alkyl chain length in determining cellular uptake and localization.

Rodriguez ME, Azizuddin K, Zhang P, Chiu SM, Lam M, Kenney ME, Burda C, Oleinick NL.

Mitochondrion. 2008 Jun;8(3):237-46. doi: 10.1016/j.mito.2008.04.003. Epub 2008 Apr 25.


Oxidative modification of cytochrome c by singlet oxygen.

Kim J, Rodriguez ME, Guo M, Kenney ME, Oleinick NL, Anderson VE.

Free Radic Biol Med. 2008 May 1;44(9):1700-11. doi: 10.1016/j.freeradbiomed.2007.12.031. Epub 2008 Jan 4.

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