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Page 1
Relationship Between Plasma Olanzapine and N-Desmethyl-Olanzapine Concentration and Metabolic Parameters in Patients With Schizophrenia.
An H, Fan H, Yun Y, Chen S, Qi S, Ma B, Shi J, Wang Z, Yang F. An H, et al. Front Psychiatry. 2022 Jun 21;13:930457. doi: 10.3389/fpsyt.2022.930457. eCollection 2022. Front Psychiatry. 2022. PMID: 35800023 Free PMC article.
OBJECTIVES: The aim of the present study was to investigate a potential relationship between metabolic parameters and steady-state plasma concentrations of olanzapine (OLA) and its metabolite, 4-N'-desmethyl-olanzapine (DMO) in patients with schizophrenia tak …
OBJECTIVES: The aim of the present study was to investigate a potential relationship between metabolic parameters and steady-state plasma …
The usefulness of Olanzapine plasma concentrations in monitoring treatment efficacy and metabolic disturbances in first-episode psychosis.
Arnaiz JA, Rodrigues-Silva C, Mezquida G, Amoretti S, Cuesta MJ, Fraguas D, Lobo A, González-Pinto A, Díaz-Caneja MC, Corripio I, Vieta E, Baeza I, Mané A, García-Rizo C, Bioque M, Saiz J, Bernardo M, Mas S; PEPs group. Arnaiz JA, et al. Psychopharmacology (Berl). 2021 Mar;238(3):665-676. doi: 10.1007/s00213-020-05715-5. Epub 2020 Nov 23. Psychopharmacology (Berl). 2021. PMID: 33230696
INTRODUCTION: The role of Olanzapine therapeutic drug monitoring is controversial. The present study explores the associations of Olanzapine plasma concentrations with clinical response and metabolic side effects in first episode psychosis (FEP) after 2 month …
INTRODUCTION: The role of Olanzapine therapeutic drug monitoring is controversial. The present study explores the associations of …
Differential effects of olanzapine and clozapine on plasma levels of adipocytokines and total ghrelin.
Lu ML, Wang TN, Lin TY, Shao WC, Chang SH, Chou JY, Ho YF, Liao YT, Chen VC. Lu ML, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Apr 3;58:47-50. doi: 10.1016/j.pnpbp.2014.12.001. Epub 2014 Dec 9. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25496829
There were significant differences in the levels of cholesterol, triglycerides, and glucose between these three groups. Post hoc comparisons showed that the olanzapine group had the highest levels of cholesterol and triglycerides. ...Olanzapine had gre …
There were significant differences in the levels of cholesterol, triglycerides, and glucose between these three groups. Post hoc comp …
Metabolic derangements with olanzapine and risperidone in schizophrenia spectrum and other psychotic disorders: A 24-week prospective study.
Rikhari P, Kumar A, Agrawal P, Kumar H. Rikhari P, et al. J Family Med Prim Care. 2022 May;11(5):2194-2200. doi: 10.4103/jfmpc.jfmpc_2161_21. Epub 2022 May 14. J Family Med Prim Care. 2022. PMID: 35800481 Free PMC article.
METHODS: This was a 24-week prospective observational study conducted at a teaching hospital in North India. The patients were prescribed olanzapine or risperidone. Anthropometric measurements (waist circumference, weight, body mass index, blood pressure) and biochemical i …
METHODS: This was a 24-week prospective observational study conducted at a teaching hospital in North India. The patients were prescribed …
Risk factors of hyperprolactinemia induced by risperidone and olanzapine and their correlations with plasma glucose and lipids.
He S, Yu WJ, Wang X, Zhang L, Zhao N, Li G, Shen YF, Li H. He S, et al. Gen Psychiatr. 2020 Jul 6;33(4):e100206. doi: 10.1136/gpsych-2020-100206. eCollection 2020. Gen Psychiatr. 2020. PMID: 32695960 Free PMC article.
AIMS: This study aimed to explore the risk factors of elevated prolactin (PRL) caused by risperidone (RIS) and olanzapine (OLZ) and the relationship between PRL and fasting plasma glucose and lipids. ...In patients taking RIS, the elevated PRL subgroup took the drug …
AIMS: This study aimed to explore the risk factors of elevated prolactin (PRL) caused by risperidone (RIS) and olanzapine (OLZ) and t …
Longitudinal Gut Microbiota Dysbiosis Underlies Olanzapine-Induced Weight Gain.
Qian L, He X, Liu Y, Gao F, Lu W, Fan Y, Gao Y, Wang W, Zhu F, Wang Y, Ma X. Qian L, et al. Microbiol Spectr. 2023 Aug 17;11(4):e0005823. doi: 10.1128/spectrum.00058-23. Epub 2023 Jun 1. Microbiol Spectr. 2023. PMID: 37260381 Free PMC article.
Olanzapine is one of the most effective medicines available for stabilizing schizophrenia spectrum disorders. ...Olanzapine significantly induced body weight gain (up to a 2.1-fold change), which was accompanied by hepatic inflammation and increased plasma …
Olanzapine is one of the most effective medicines available for stabilizing schizophrenia spectrum disorders. ...Olanzapine si …
Metabolic Effects of Aripiprazole and Olanzapine Multiple-Dose Treatment in a Randomised Crossover Clinical Trial in Healthy Volunteers: Association with Pharmacogenetics.
Koller D, Almenara S, Mejía G, Saiz-Rodríguez M, Zubiaur P, Román M, Ochoa D, Navares-Gómez M, Santos-Molina E, Pintos-Sánchez E, Abad-Santos F. Koller D, et al. Adv Ther. 2021 Feb;38(2):1035-1054. doi: 10.1007/s12325-020-01566-w. Epub 2020 Dec 5. Adv Ther. 2021. PMID: 33278020 Free PMC article. Clinical Trial.
RESULTS: Olanzapine induced hyperprolactinaemia but aripiprazole did not. Dopamine D3 receptor (DRD3) Ser/Gly and ATP binding cassette subfamily B member 1 (ABCB1) rs10280101, rs12720067 and rs11983225 polymorphisms and cytochrome P450 3A (CYP3A) phenotype had an impact on …
RESULTS: Olanzapine induced hyperprolactinaemia but aripiprazole did not. Dopamine D3 receptor (DRD3) Ser/Gly and ATP binding cassett …
Effects of olanzapine and haloperidol on the metabolic status of healthy men.
Vidarsdottir S, de Leeuw van Weenen JE, Frölich M, Roelfsema F, Romijn JA, Pijl H. Vidarsdottir S, et al. J Clin Endocrinol Metab. 2010 Jan;95(1):118-25. doi: 10.1210/jc.2008-1815. Epub 2009 Nov 11. J Clin Endocrinol Metab. 2010. PMID: 19906788 Clinical Trial.
Also, the glycerol rate of appearance (a measure of lipolysis rate) was not affected by either drug. Olanzapine, but not haloperidol, blunted the insulin-induced decline of plasma free fatty acid and triglyceride concentrations. ...Moreover, olanzapine …
Also, the glycerol rate of appearance (a measure of lipolysis rate) was not affected by either drug. Olanzapine, but not haloperidol, …
Alterations in sorting and secretion of hepatic apoA5 induce hypertriglyceridemia due to short-term use of olanzapine.
Huang PP, Zhu WQ, Xiao JM, Zhang YQ, Li R, Yang Y, Shen L, Luo F, Dai W, Lian PA, Tang YX, Ran JL, Huang XS. Huang PP, et al. Front Pharmacol. 2022 Aug 12;13:935362. doi: 10.3389/fphar.2022.935362. eCollection 2022. Front Pharmacol. 2022. PMID: 36034782 Free PMC article.
However, the effects and underlying mechanisms of short-term use of olanzapine on circulating triglyceride levels remain poorly understood. ...We demonstrated that short-term use of olanzapine increased plasma triglyceride and decreased plasm …
However, the effects and underlying mechanisms of short-term use of olanzapine on circulating triglyceride levels remain poorl …
Hyperglycemia and antipsychotic medications.
Haupt DW, Newcomer JW. Haupt DW, et al. J Clin Psychiatry. 2001;62 Suppl 27:15-26; discussion 40-1. J Clin Psychiatry. 2001. PMID: 11806485 Review.
However, case reports and recent controlled studies suggest that clozapine and olanzapine treatment may also be associated with adverse effects on glucose metabolism independent of adiposity. Dyslipidemia is a feature of type 2 diabetes, and antipsychotics such as clozapin …
However, case reports and recent controlled studies suggest that clozapine and olanzapine treatment may also be associated with adver …
75 results