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Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles.

Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R.

Proc Natl Acad Sci U S A. 2016 May 2. pii: 201603840. [Epub ahead of print]


GQ-16, a TZD-Derived Partial PPARγ Agonist, Induces the Expression of Thermogenesis-Related Genes in Brown Fat and Visceral White Fat and Decreases Visceral Adiposity in Obese and Hyperglycemic Mice.

Coelho MS, de Lima CL, Royer C, Silva JB, Oliveira FC, Christ CG, Pereira SA, Bao SN, Lima MC, Pitta MG, Pitta IR, Neves FA, Amato AA.

PLoS One. 2016 May 3;11(5):e0154310. doi: 10.1371/journal.pone.0154310. eCollection 2016.


Visceral adiposity predicts subclinical white matter hyperintensities in middle-aged adults.

Pasha EP, Birdsill A, Parker P, Elmenshawy A, Tanaka H, Haley AP.

Obes Res Clin Pract. 2016 Apr 28. pii: S1871-403X(16)30015-1. doi: 10.1016/j.orcp.2016.04.003. [Epub ahead of print]


A polyphenol-rich fraction obtained from table grapes decreases adiposity, insulin resistance and markers of inflammation and impacts gut microbiota in high-fat-fed mice.

Collins B, Hoffman J, Martinez K, Grace M, Lila MA, Cockrell C, Nadimpalli A, Chang E, Chuang CC, Zhong W, Mackert J, Shen W, Cooney P, Hopkins R, McIntosh M.

J Nutr Biochem. 2016 Feb 26;31:150-165. doi: 10.1016/j.jnutbio.2015.12.021. [Epub ahead of print]


Heat Shock Factor-1 Knockout Enhances Cholesterol 7α Hydroxylase (CYP7A1) and Multidrug Transporter (MDR1) Gene Expressions to Attenuate Atherosclerosis.

Krishnamurthy K, Glaser S, Alpini G, Cardounel AJ, Liu Z, Ilangovan G.

Cardiovasc Res. 2016 Apr 30. pii: cvw094. [Epub ahead of print]


Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes.

Huttala O, Mysore R, Sarkanen JR, Heinonen T, Olkkonen VM, Ylikomi T.

Cell Tissue Res. 2016 Apr 29. [Epub ahead of print]


Prostaglandin E2 Exerts Multiple Regulatory Actions on Human Obese Adipose Tissue Remodeling, Inflammation, Adaptive Thermogenesis and Lipolysis.

García-Alonso V, Titos E, Alcaraz-Quiles J, Rius B, Lopategi A, López-Vicario C, Jakobsson PJ, Delgado S, Lozano J, Clària J.

PLoS One. 2016 Apr 28;11(4):e0153751. doi: 10.1371/journal.pone.0153751. eCollection 2016.


Depot- and sex-specific effects of maternal obesity in offspring's adipose tissue.

Lecoutre S, Deracinois B, Laborie C, Eberlé D, Guinez C, Panchenko PE, Lesage J, Vieau D, Junien C, Gabory A, Breton C.

J Endocrinol. 2016 Apr 27. pii: JOE-16-0037. [Epub ahead of print]


White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways.

Barquissau V, Beuzelin D, Pisani DF, Beranger GE, Mairal A, Montagner A, Roussel B, Tavernier G, Marques MA, Moro C, Guillou H, Amri EZ, Langin D.

Mol Metab. 2016 Mar 18;5(5):352-65. doi: 10.1016/j.molmet.2016.03.002. eCollection 2016 May.


Thioesterase superfamily member 1 suppresses cold thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids in brown adipose tissue.

Okada K, LeClair KB, Zhang Y, Li Y, Ozdemir C, Krisko TI, Hagen SJ, Betensky RA, Banks AS, Cohen DE.

Mol Metab. 2016 Feb 23;5(5):340-51. doi: 10.1016/j.molmet.2016.02.002. eCollection 2016 May.


Dietary intervention in obese dams protects male offspring from WAT induction of TRPV4, adiposity, and hyperinsulinemia.

Janoschek R, Bae-Gartz I, Vohlen C, Alcázar MA, Dinger K, Appel S, Dötsch J, Hucklenbruch-Rother E.

Obesity (Silver Spring). 2016 Apr 23. doi: 10.1002/oby.21486. [Epub ahead of print]


Treadmill Intervention Attenuates the Cafeteria Diet-Induced Impairment of Stress-Coping Strategies in Young Adult Female Rats.

Cigarroa I, Lalanza JF, Caimari A, Del Bas JM, Capdevila L, Arola L, Escorihuela RM.

PLoS One. 2016 Apr 21;11(4):e0153687. doi: 10.1371/journal.pone.0153687. eCollection 2016.


Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism.

Tang Y, Wallace M, Sanchez-Gurmaches J, Hsiao WY, Li H, Lee PL, Vernia S, Metallo CM, Guertin DA.

Nat Commun. 2016 Apr 21;7:11365. doi: 10.1038/ncomms11365.


Protein kinase A induces UCP1 expression in specific adipose depots to increase energy expenditure and improve metabolic health.

Dickson LM, Gandhi S, Layden BT, Cohen RN, Wicksteed B.

Am J Physiol Regul Integr Comp Physiol. 2016 Apr 20:ajpregu.00114.2016. doi: 10.1152/ajpregu.00114.2016. [Epub ahead of print]


Betatrophin expression is promoted in obese hyperinsulinemic type 2 but not type 1 diabetic mice.

Li E, Nakata M, Shinozaki A, Yang Y, Zhang B, Yada T.

Endocr J. 2016 Apr 19. [Epub ahead of print]


Hypoxia-inducible factor prolyl hydroxylase 1 (PHD1) deficiency promotes hepatic steatosis and liver-specific insulin resistance in mice.

Thomas A, Belaidi E, Aron-Wisnewsky J, van der Zon GC, Levy P, Clement K, Pepin JL, Godin-Ribuot D, Guigas B.

Sci Rep. 2016 Apr 20;6:24618. doi: 10.1038/srep24618.


Marrow Adipose Tissue: Trimming the Fat.

Scheller EL, Cawthorn WP, Burr AA, Horowitz MC, MacDougald OA.

Trends Endocrinol Metab. 2016 Apr 16. pii: S1043-2760(16)30002-9. doi: 10.1016/j.tem.2016.03.016. [Epub ahead of print] Review.


Gpr97 is dispensable for metabolic syndrome but is involved in macrophage inflammation in high-fat diet-induced obesity in mice.

Shi J, Zhang X, Wang S, Wang J, Du B, Wang Z, Liu M, Jiang W, Qian M, Ren H.

Sci Rep. 2016 Apr 19;6:24649. doi: 10.1038/srep24649.


Body mass index and the visceral adipose tissue expression of IL-6 and TNF-alpha are associated with the morphological severity of non-alcoholic fatty liver disease in individuals with class III obesity.

Jorge AS, Andrade JM, Paraíso AF, Jorge GC, Silveira CM, de Souza LR, Santos EP, Guimaraes AL, Santos SH, De-Paula AM.

Obes Res Clin Pract. 2016 Apr 12. pii: S1871-403X(16)30006-0. doi: 10.1016/j.orcp.2016.03.009. [Epub ahead of print]


Obesity and Cancer: Concepts and Challenges.

Argolo DF, Iyengar NM, Hudis CA.

Indian J Surg Oncol. 2015 Dec;6(4):390-8. doi: 10.1007/s13193-015-0483-z. Epub 2015 Nov 23. Erratum in: Indian J Surg Oncol. 2015 Dec;6(4):399.

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