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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1828 1
1839 1
1842 1
1843 1
1844 1
1846 1
1855 1
1857 1
1867 1
1883 2
1900 1
1901 1
1916 2
1920 1
1923 2
1924 1
1933 2
1936 1
1939 1
1941 1
1945 1
1947 1
1948 4
1949 2
1950 2
1951 7
1952 4
1953 6
1954 7
1955 4
1956 3
1957 6
1958 6
1959 1
1960 3
1961 3
1962 6
1963 6
1964 12
1965 11
1966 8
1967 8
1968 11
1969 14
1970 9
1971 12
1972 10
1973 14
1974 13
1975 56
1976 54
1977 57
1978 44
1979 53
1980 56
1981 76
1982 60
1983 80
1984 96
1985 100
1986 95
1987 107
1988 103
1989 135
1990 155
1991 171
1992 169
1993 224
1994 193
1995 204
1996 259
1997 318
1998 360
1999 396
2000 522
2001 540
2002 619
2003 637
2004 728
2005 881
2006 962
2007 1105
2008 1227
2009 1292
2010 1392
2011 1644
2012 1757
2013 1860
2014 2000
2015 2106
2016 2020
2017 2096
2018 2212
2019 2261
2020 2473
2021 2643
2022 2507
2023 2447
2024 981

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38,400 results

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Page 1
The role of Notch receptors in transcriptional regulation.
Wang H, Zang C, Liu XS, Aster JC. Wang H, et al. J Cell Physiol. 2015 May;230(5):982-8. doi: 10.1002/jcp.24872. J Cell Physiol. 2015. PMID: 25418913 Free PMC article. Review.
Notch receptor signaling is mediated by tightly regulated proteolytic cleavages that lead to the assembly of a nuclear Notch transcription complex, which drives the expression of downstream target genes and thereby executes Notch's functions. Thus, und …
Notch receptor signaling is mediated by tightly regulated proteolytic cleavages that lead to the assembly of a nuclear Notch t …
Notch Pathway: A Journey from Notching Phenotypes to Cancer Immunotherapy.
Monticone G, Miele L. Monticone G, et al. Adv Exp Med Biol. 2021;1287:201-222. doi: 10.1007/978-3-030-55031-8_13. Adv Exp Med Biol. 2021. PMID: 33034034 Review.
The study of Notch has greatly contributed to the understanding of cancer biology and a substantial effort has been spent in designing Notch-targeting therapies. ...However, this means that Notch-based therapies must be highly specific to avoid off-target eff …
The study of Notch has greatly contributed to the understanding of cancer biology and a substantial effort has been spent in designin …
The Notch Pathway in Breast Cancer Progression.
Kontomanolis EN, Kalagasidou S, Pouliliou S, Anthoulaki X, Georgiou N, Papamanolis V, Fasoulakis ZN. Kontomanolis EN, et al. ScientificWorldJournal. 2018 Jul 8;2018:2415489. doi: 10.1155/2018/2415489. eCollection 2018. ScientificWorldJournal. 2018. PMID: 30111989 Free PMC article. Review.
In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progression and the therapeutic role of Notch's inhibition. ...The cross-talk of Notch and estrogens, the effect of Notch …
In this review, the authors summarize the current knowledge about the impact of the Notch signaling pathway in breast cancer progress …
Notch notches lupus.
Tsokos GC. Tsokos GC. Kidney Int. 2020 Feb;97(2):251-253. doi: 10.1016/j.kint.2019.10.018. Kidney Int. 2020. PMID: 31980071 Free article.
The multifaceted Notch signaling pathway appears to tame the autoimmune response and protect lupus-prone mice from inflammation and damage....
The multifaceted Notch signaling pathway appears to tame the autoimmune response and protect lupus-prone mice from inflammation and d …
Current Thoughts of Notch's Role in Myoblast Regulation and Muscle-Associated Disease.
Gerrard JC, Hay JP, Adams RN, Williams JC 3rd, Huot JR, Weathers KM, Marino JS, Arthur ST. Gerrard JC, et al. Int J Environ Res Public Health. 2021 Nov 29;18(23):12558. doi: 10.3390/ijerph182312558. Int J Environ Res Public Health. 2021. PMID: 34886282 Free PMC article. Review.
The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch's contribution to the muscle repair process in adult tissue is complex and obscure but necessary. ...Understanding the mechanisms of Notch's …
The evolutionarily conserved signaling pathway Notch is unequivocally essential for embryogenesis. Notch's contribution …
Context-dependent regulation of Notch signaling in glial development and tumorigenesis.
Guo R, Han D, Song X, Gao Y, Li Z, Li X, Yang Z, Xu Z. Guo R, et al. Sci Adv. 2023 Nov 10;9(45):eadi2167. doi: 10.1126/sciadv.adi2167. Epub 2023 Nov 10. Sci Adv. 2023. PMID: 37948517 Free PMC article.
Inhibiting Notch in glial progenitors does not affect cell generation but instead accelerates the growth of Notch-deprived oligodendrocyte progenitor cells (OPCs) and OPC-related glioma. ...Our study reveals Notch's context-dependent function, promotin …
Inhibiting Notch in glial progenitors does not affect cell generation but instead accelerates the growth of Notch-deprived oli …
Notch Signaling and Tissue Patterning in Embryology: An Introduction.
Reichrath J, Reichrath S. Reichrath J, et al. Adv Exp Med Biol. 2020;1218:1-7. doi: 10.1007/978-3-030-34436-8_1. Adv Exp Med Biol. 2020. PMID: 32060868
The attention of science first turned to the gene that later earned the name Notch over a century ago, when the American scientist John S. Dexter discovered in his laboratory at Olivet College the characteristic notched-wing phenotype (a nick or notch in the …
The attention of science first turned to the gene that later earned the name Notch over a century ago, when the American scientist Jo …
Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?
Zhang M, Biswas S, Qin X, Gong W, Deng W, Yu H. Zhang M, et al. Cancer Med. 2016 Aug;5(8):2048-60. doi: 10.1002/cam4.731. Epub 2016 May 26. Cancer Med. 2016. PMID: 27228302 Free PMC article. Review.
Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the pathogenesis of SCCs. In this review, evidences highlighting NOTCH's role in different types of SCCs are summarized. Moreover, …
Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the …
Oncogenic programmes and Notch activity: an 'organized crime'?
Dominguez M. Dominguez M. Semin Cell Dev Biol. 2014 Apr;28:78-85. doi: 10.1016/j.semcdb.2014.04.012. Epub 2014 Apr 26. Semin Cell Dev Biol. 2014. PMID: 24780858 Review.
The fly eye is not only a non-vital organ but its stereotyped size and disposition also means it is easy to screen for mutations that cause tumours and metastases and provides ample opportunities to test cancer theories and to unravel unanticipated nexus between Notch and …
The fly eye is not only a non-vital organ but its stereotyped size and disposition also means it is easy to screen for mutations that cause …
Notch signalling and haematopoietic stem cell formation during embryogenesis.
Gering M, Patient R. Gering M, et al. J Cell Physiol. 2010 Jan;222(1):11-6. doi: 10.1002/jcp.21905. J Cell Physiol. 2010. PMID: 19725072 Review.
The Notch signalling pathway is repeatedly employed during embryonic development and adult homeostasis of a variety of tissues. ...Here, we review its role in the development of haematopoietic stem cells during vertebrate embryogenesis and put it into the context of Not …
The Notch signalling pathway is repeatedly employed during embryonic development and adult homeostasis of a variety of tissues. ...He …
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