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Year Number of Results
1946 1
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1971 1
1973 5
1974 1
1975 1
1976 10
1977 45
1978 118
1979 160
1980 190
1981 219
1982 252
1983 257
1984 241
1985 182
1986 222
1987 209
1988 271
1989 222
1990 331
1991 326
1992 296
1993 368
1994 314
1995 260
1996 336
1997 308
1998 315
1999 423
2000 430
2001 479
2002 440
2003 386
2004 488
2005 487
2006 516
2007 531
2008 563
2009 500
2010 518
2011 447
2012 346
2013 318
2014 373
2015 343
2016 295
2017 289
2018 323
2019 333
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2024 111

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14,732 results

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Page 1
Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.
Pinho-Ribeiro FA, Verri WA Jr, Chiu IM. Pinho-Ribeiro FA, et al. Trends Immunol. 2017 Jan;38(1):5-19. doi: 10.1016/j.it.2016.10.001. Epub 2016 Oct 25. Trends Immunol. 2017. PMID: 27793571 Free PMC article. Review.
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving avoidance. ...Therefore, the dialog between nociceptor neurons and the immune system is a fundamental aspect of inflammation, both acute and chronic. ...
Nociceptor sensory neurons protect organisms from danger by eliciting pain and driving avoidance. ...Therefore, the dialog between …
Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection.
Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Yang D, et al. Cell. 2022 Oct 27;185(22):4190-4205.e25. doi: 10.1016/j.cell.2022.09.024. Epub 2022 Oct 14. Cell. 2022. PMID: 36243004 Free PMC article.
Nociceptor ablation led to decreased mucus thickness and dysbiosis, while chemogenetic nociceptor activation or capsaicin treatment induced mucus growth. ...Notably, commensal microbes activated nociceptors to control homeostatic CGRP release. In the absence …
Nociceptor ablation led to decreased mucus thickness and dysbiosis, while chemogenetic nociceptor activation or capsaicin trea …
Decoding nociceptor-DC dialogues.
Crosson T, Talbot S. Crosson T, et al. Immunity. 2023 May 9;56(5):906-908. doi: 10.1016/j.immuni.2023.04.016. Immunity. 2023. PMID: 37163991
Neuro-immune interactions link physiological and immune responses in host defense. Hanc et al.(1) report that nociceptors attract dendritic cells (DCs) via the chemokine (C-C motif) ligand 2 (CCL2), initiate a "sentinel" DC program via the neuropeptide calcitonin gene-rela …
Neuro-immune interactions link physiological and immune responses in host defense. Hanc et al.(1) report that nociceptors attract den …
Persistent nociceptor hyperactivity as a painful evolutionary adaptation.
Walters ET, Crook RJ, Neely GG, Price TJ, Smith ESJ. Walters ET, et al. Trends Neurosci. 2023 Mar;46(3):211-227. doi: 10.1016/j.tins.2022.12.007. Epub 2023 Jan 5. Trends Neurosci. 2023. PMID: 36610893 Free PMC article. Review.
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been linked to persistent electrical hyperactivity of the sensory neurons (nociceptors) specialized to detect damaging stimuli and/or inflammation. ...While the assumption of maladaptiven …
Chronic pain caused by injury or disease of the nervous system (neuropathic pain) has been linked to persistent electrical hyperactivity of …
Nociceptor-Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain.
Menon N, Kishen A. Menon N, et al. Biomolecules. 2023 Jul 31;13(8):1193. doi: 10.3390/biom13081193. Biomolecules. 2023. PMID: 37627258 Free PMC article. Review.
Studies have investigated neuroanatomy and measured the levels of biomolecules such as cytokines and neuropeptides in human saliva, gingival crevicular fluid, or blood/serum samples in apical periodontitis (AP) to validate the possible role of trigeminal nociceptors in inf …
Studies have investigated neuroanatomy and measured the levels of biomolecules such as cytokines and neuropeptides in human saliva, gingival …
Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense.
Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Lai NY, et al. Cell. 2020 Jan 9;180(1):33-49.e22. doi: 10.1016/j.cell.2019.11.014. Epub 2019 Dec 5. Cell. 2020. PMID: 31813624 Free PMC article.
Dorsal root ganglia nociceptors protect against STm colonization, invasion, and dissemination from the gut. ...These findings reveal a major role for nociceptor neurons in sensing and defending against enteric pathogens....
Dorsal root ganglia nociceptors protect against STm colonization, invasion, and dissemination from the gut. ...These findings reveal …
Nociceptor plasticity: A closer look.
Pace MC, Passavanti MB, De Nardis L, Bosco F, Sansone P, Pota V, Barbarisi M, Palagiano A, Iannotti FA, Panza E, Aurilio C. Pace MC, et al. J Cell Physiol. 2018 Apr;233(4):2824-2838. doi: 10.1002/jcp.25993. Epub 2017 Jun 15. J Cell Physiol. 2018. PMID: 28488779 Review.
Nociceptors are receptors specifically involved in detecting a tissue damage and transducing it in an electrical signal. Nociceptor activation provoked by any kind of acute lesion is related to the release of several mediators of inflammation, within the framework o …
Nociceptors are receptors specifically involved in detecting a tissue damage and transducing it in an electrical signal. Nocicepto …
Nociceptor Signalling through ion Channel Regulation via GPCRs.
Salzer I, Ray S, Schicker K, Boehm S. Salzer I, et al. Int J Mol Sci. 2019 May 20;20(10):2488. doi: 10.3390/ijms20102488. Int J Mol Sci. 2019. PMID: 31137507 Free PMC article. Review.
This function of nociceptors relies on the coordinated operation of a variety of ion channels. ...Thereby, this review provides information on how ion channel modulation via G protein coupled receptors in nociceptors can be exploited to provide improved analgesic th …
This function of nociceptors relies on the coordinated operation of a variety of ion channels. ...Thereby, this review provides infor …
Role of TMEM100 in mechanically insensitive nociceptor un-silencing.
Nees TA, Wang N, Adamek P, Zeitzschel N, Verkest C, La Porta C, Schaefer I, Virnich J, Balkaya S, Prato V, Morelli C, Begay V, Lee YJ, Tappe-Theodor A, Lewin GR, Heppenstall PA, Taberner FJ, Lechner SG. Nees TA, et al. Nat Commun. 2023 Apr 5;14(1):1899. doi: 10.1038/s41467-023-37602-w. Nat Commun. 2023. PMID: 37019973 Free PMC article.
Mechanically silent nociceptors are sensory afferents that are insensitive to noxious mechanical stimuli under normal conditions but become sensitized to such stimuli during inflammation. Using RNA-sequencing and quantitative RT-PCR we demonstrate that inflammation upregul …
Mechanically silent nociceptors are sensory afferents that are insensitive to noxious mechanical stimuli under normal conditions but …
Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain.
Walters ET. Walters ET. Brain Behav Evol. 2023;98(6):314-330. doi: 10.1159/000535552. Epub 2023 Nov 30. Brain Behav Evol. 2023. PMID: 38035556 Review.
In mammals, OA and SA are often initiated within the protected nociceptor soma long after an inducing injury. Generation of OA or SA in nociceptor somata may be very rare in invertebrates, but prolonged afterdischarge in nociceptor somata readily occurs in se …
In mammals, OA and SA are often initiated within the protected nociceptor soma long after an inducing injury. Generation of OA or SA …
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