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1979 1
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1998 1
2002 1
2004 1
2005 2
2006 2
2008 2
2009 1
2010 5
2011 4
2012 6
2013 9
2014 10
2015 10
2016 21
2017 13
2018 19
2019 19
2020 17
2021 26
2022 23
2023 30
2024 14

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216 results

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Page 1
Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus.
Weyrich LS, Duchene S, Soubrier J, Arriola L, Llamas B, Breen J, Morris AG, Alt KW, Caramelli D, Dresely V, Farrell M, Farrer AG, Francken M, Gully N, Haak W, Hardy K, Harvati K, Held P, Holmes EC, Kaidonis J, Lalueza-Fox C, de la Rasilla M, Rosas A, Semal P, Soltysiak A, Townsend G, Usai D, Wahl J, Huson DH, Dobney K, Cooper A. Weyrich LS, et al. Nature. 2017 Apr 20;544(7650):357-361. doi: 10.1038/nature21674. Epub 2017 Mar 8. Nature. 2017. PMID: 28273061 Free article.
Recent genomic data have revealed multiple interactions between Neanderthals and modern humans, but there is currently little genetic evidence regarding Neanderthal behaviour, diet, or disease. ...Differences in diet were also linked to an overall shift in the oral …
Recent genomic data have revealed multiple interactions between Neanderthals and modern humans, but there is currently little genetic …
Arthritis.
Senthelal S, Li J, Ardeshirzadeh S, Thomas MA. Senthelal S, et al. 2023 Jun 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jun 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30085534 Free Books & Documents.
Arthritis is not synonymous with arthralgia, which refers to pain localized to a joint, regardless of the origin of the pain (which may or may not be due to joint inflammation). Arthritis affected both the Neanderthals and ancient Egyptians, but It was not until 1886 that …
Arthritis is not synonymous with arthralgia, which refers to pain localized to a joint, regardless of the origin of the pain (which may or m …
The complete genome sequence of a Neanderthal from the Altai Mountains.
Prüfer K, Racimo F, Patterson N, Jay F, Sankararaman S, Sawyer S, Heinze A, Renaud G, Sudmant PH, de Filippo C, Li H, Mallick S, Dannemann M, Fu Q, Kircher M, Kuhlwilm M, Lachmann M, Meyer M, Ongyerth M, Siebauer M, Theunert C, Tandon A, Moorjani P, Pickrell J, Mullikin JC, Vohr SH, Green RE, Hellmann I, Johnson PL, Blanche H, Cann H, Kitzman JO, Shendure J, Eichler EE, Lein ES, Bakken TE, Golovanova LV, Doronichev VB, Shunkov MV, Derevianko AP, Viola B, Slatkin M, Reich D, Kelso J, Pääbo S. Prüfer K, et al. Nature. 2014 Jan 2;505(7481):43-9. doi: 10.1038/nature12886. Epub 2013 Dec 18. Nature. 2014. PMID: 24352235 Free PMC article.
We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population history of available archaic genomes and 25 present-day human genomes shows that several gene flow events occurred among Neanderthals, De …
We also sequenced the genome of a Neanderthal from the Caucasus to low coverage. An analysis of the relationships and population hist …
Adaptive sequence divergence forged new neurodevelopmental enhancers in humans.
Mangan RJ, Alsina FC, Mosti F, Sotelo-Fonseca JE, Snellings DA, Au EH, Carvalho J, Sathyan L, Johnson GD, Reddy TE, Silver DL, Lowe CB. Mangan RJ, et al. Cell. 2022 Nov 23;185(24):4587-4603.e23. doi: 10.1016/j.cell.2022.10.016. Cell. 2022. PMID: 36423581 Free PMC article.
Here, we demonstrate that the fastest-evolved regions of the human genome, which we term "human ancestor quickly evolved regions" (HAQERs), rapidly diverged in an episodic burst of directional positive selection prior to the human-Neanderthal split, before transitioning to …
Here, we demonstrate that the fastest-evolved regions of the human genome, which we term "human ancestor quickly evolved regions" (HAQERs), …
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity.
Faux P, Ding L, Ramirez-Aristeguieta LM, Chacón-Duque JC, Comini M, Mendoza-Revilla J, Fuentes-Guajardo M, Jaramillo C, Arias W, Hurtado M, Villegas V, Granja V, Barquera R, Everardo-Martínez P, Quinto-Sánchez M, Gómez-Valdés J, Villamil-Ramírez H, Silva de Cerqueira CC, Hünemeier T, Ramallo V, Gonzalez-José R, Schüler-Faccini L, Bortolini MC, Acuña-Alonzo V, Canizales-Quinteros S, Poletti G, Gallo C, Rothhammer F, Rojas W, Schmid AB, Adhikari K, Bennett DL, Ruiz-Linares A. Faux P, et al. Commun Biol. 2023 Oct 10;6(1):958. doi: 10.1038/s42003-023-05286-z. Commun Biol. 2023. PMID: 37816865 Free PMC article.
Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. ...Our findings support the reported associatio …
Three functional variants in the SCN9A gene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from …
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals.
Pinson A, Xing L, Namba T, Kalebic N, Peters J, Oegema CE, Traikov S, Reppe K, Riesenberg S, Maricic T, Derihaci R, Wimberger P, Pääbo S, Huttner WB. Pinson A, et al. Science. 2022 Sep 9;377(6611):eabl6422. doi: 10.1126/science.abl6422. Epub 2022 Sep 9. Science. 2022. PMID: 36074851
Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis during neocortex development. ...Our data suggest that neocortical neurogenesis in modern humans differs from that in Neanderthals....
Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis dur …
Svante Paabo, reader of the Neanderthal genome.
Wielgus K, Danielewski M, Walkowiak J. Wielgus K, et al. Acta Physiol (Oxf). 2023 Jan;237(1):e13902. doi: 10.1111/apha.13902. Epub 2022 Nov 23. Acta Physiol (Oxf). 2023. PMID: 36394417 Free PMC article. No abstract available.
A high-coverage genome sequence from an archaic Denisovan individual.
Meyer M, Kircher M, Gansauge MT, Li H, Racimo F, Mallick S, Schraiber JG, Jay F, Prüfer K, de Filippo C, Sudmant PH, Alkan C, Fu Q, Do R, Rohland N, Tandon A, Siebauer M, Green RE, Bryc K, Briggs AW, Stenzel U, Dabney J, Shendure J, Kitzman J, Hammer MF, Shunkov MV, Derevianko AP, Patterson N, Andrés AM, Eichler EE, Slatkin M, Reich D, Kelso J, Pääbo S. Meyer M, et al. Science. 2012 Oct 12;338(6104):222-6. doi: 10.1126/science.1224344. Epub 2012 Aug 30. Science. 2012. PMID: 22936568 Free PMC article.
Insights into human genetic variation and population history from 929 diverse genomes.
Bergström A, McCarthy SA, Hui R, Almarri MA, Ayub Q, Danecek P, Chen Y, Felkel S, Hallast P, Kamm J, Blanché H, Deleuze JF, Cann H, Mallick S, Reich D, Sandhu MS, Skoglund P, Scally A, Xue Y, Durbin R, Tyler-Smith C. Bergström A, et al. Science. 2020 Mar 20;367(6484):eaay5012. doi: 10.1126/science.aay5012. Science. 2020. PMID: 32193295 Free PMC article.
We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agriculturalist groups in the past 10,000 years, and a contrast between single Neanderthal but multiple Denisovan source populations contri …
We also find deep and gradual population separations within Africa, contrasting population size histories between hunter-gatherer and agricu …
The contribution of Neanderthal introgression and natural selection to neurodegenerative diseases.
Chen Z, Reynolds RH, Pardiñas AF, Gagliano Taliun SA, van Rheenen W, Lin K, Shatunov A, Gustavsson EK, Fogh I, Jones AR, Robberecht W, Corcia P, Chiò A, Shaw PJ, Morrison KE, Veldink JH, van den Berg LH, Shaw CE, Powell JF, Silani V, Hardy JA, Houlden H, Owen MJ, Turner MR, Ryten M, Al-Chalabi A. Chen Z, et al. Neurobiol Dis. 2023 May;180:106082. doi: 10.1016/j.nbd.2023.106082. Epub 2023 Mar 15. Neurobiol Dis. 2023. PMID: 36925053 Free article.
In this study, we aimed to quantify the genome-wide contribution of Neanderthal introgression and positive selection to the heritability of complex neurodegenerative disorders to address these questions. ...We found no evidence for enrichment of positively-selected SNPs in …
In this study, we aimed to quantify the genome-wide contribution of Neanderthal introgression and positive selection to the heritabil …
216 results