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A disturbed interaction with accessory cells upon opportunistic infection with Pseudomonas aeruginosa contributes to an impaired IFN-gamma production of NK cells in the lung during sepsis-induced immunosuppression.
Pastille E, Pohlmann S, Wirsdörfer F, Reib A, Flohé SB. Pastille E, et al. Innate Immun. 2015 Feb;21(2):115-26. doi: 10.1177/1753425913517274. Epub 2014 Jan 9. Innate Immun. 2015. PMID: 24406749 Free article.
Impaired resistance to Pseudomonas aeruginosa-induced pneumonia after cecal ligation and puncture (CLP), a mouse model for human polymicrobial sepsis, is associated with decreased IFN-gamma, but increased IL-10, levels in the lung. ...Thus, a disturbed intera …
Impaired resistance to Pseudomonas aeruginosa-induced pneumonia after cecal ligation and puncture (CLP), a mouse model …
Characterization and modulation of the immunosuppressive phase of sepsis.
Muenzer JT, Davis CG, Chang K, Schmidt RE, Dunne WM, Coopersmith CM, Hotchkiss RS. Muenzer JT, et al. Infect Immun. 2010 Apr;78(4):1582-92. doi: 10.1128/IAI.01213-09. Epub 2010 Jan 25. Infect Immun. 2010. PMID: 20100863 Free PMC article.
Using a clinically relevant two-hit model of sepsis, i.e., cecal ligation and puncture (CLP) followed by the induction of Pseudomonas aeruginosa pneumonia, we characterized the host immune response. ...However, by 7 days post-CLP, the host's immune …
Using a clinically relevant two-hit model of sepsis, i.e., cecal ligation and puncture (CLP) followed by the induction of Pseudomonas …
Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1-positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study.
Wang Y, Tian GB, Zhang R, Shen Y, Tyrrell JM, Huang X, Zhou H, Lei L, Li HY, Doi Y, Fang Y, Ren H, Zhong LL, Shen Z, Zeng KJ, Wang S, Liu JH, Wu C, Walsh TR, Shen J. Wang Y, et al. Lancet Infect Dis. 2017 Apr;17(4):390-399. doi: 10.1016/S1473-3099(16)30527-8. Epub 2017 Jan 28. Lancet Infect Dis. 2017. PMID: 28139431
FINDINGS: We identified 21 621 non-duplicate isolates of Enterobacteriaceae, Acinetobacter spp, and Pseudomonas aeruginosa from 18 698 inpatients and 2923 healthy volunteers. ...INTERPRETATION: In 2017, colistin will be formally banned from animal feeds in China and …
FINDINGS: We identified 21 621 non-duplicate isolates of Enterobacteriaceae, Acinetobacter spp, and Pseudomonas aeruginosa fro …
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.
Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS. Inoue S, et al. J Immunol. 2010 Feb 1;184(3):1401-9. doi: 10.4049/jimmunol.0902307. Epub 2009 Dec 21. J Immunol. 2010. PMID: 20026737 Free PMC article.
This study tested the ability of IL-15 to block apoptosis, prevent immunosuppression, and improve survival in sepsis. Mice were made septic using cecal ligation and puncture or Pseudomonas aeruginosa pneumonia. ...Finally, IL-15 increased survival in b …
This study tested the ability of IL-15 to block apoptosis, prevent immunosuppression, and improve survival in sepsis. Mice were made …
Pulmonary infiltrates in immunocompromised patients: diagnosis by cytological examination of bronchoalveolar lavage fluid.
Young JA, Hopkin JM, Cuthbertson WP. Young JA, et al. J Clin Pathol. 1984 Apr;37(4):390-7. doi: 10.1136/jcp.37.4.390. J Clin Pathol. 1984. PMID: 6368604 Free PMC article.
Thirty pulmonary infiltrates in 26 patients were investigated by bronchoalveolar lavage. Sixteen of the patients were on therapeutic immunosuppression for renal disease or transplant and 10 had leukaemia, lymphoma, or allied conditions. ...In seven cases with non-di …
Thirty pulmonary infiltrates in 26 patients were investigated by bronchoalveolar lavage. Sixteen of the patients were on therapeutic …