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PMC Images search for myelin schizophrenia

Figure 1Oligodendrocyte and myelin and synaptic function

Oligodendrocytes wrap axons and form electrical insulation, myelin that enhances conduction of nerve impulses. Altered oligodendrocytes and myelin reduces conduction velocity. Also impairment in oligodendrocytes and myelin alters axonal growth/sprouting and synaptic plasticity in the synapse.

Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia

Prog Neurobiol. 2011 January;93(1):13-24.
Figure 6

Electron micrographs of oligodendrocytes and microglia in white matter from control subjects (a) and from subjects with schizophrenia (b–d). Dystrophic changes of oligodendrocyte, Ol, (b). Activated microglia in close apposition to swollen astrocytic process (Ap) containing myelin debris in schizophrenia brain (c) Microglial cell participates in phagocytosis of myelin membranous debris in schizophrenia (d). Scale bars = 2 μm.

Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study

Schizophr Res Treatment. 2011;2011:325789.
Figure 3

Graphic representation of potential WM changes in schizophrenia consistent with our T2 findings. The T2 of each metabolite is represented by the size of the starburst pattern. Note that in schizophrenia a reduction in myelin content would lead to prolonged water T2, while reduction in axon size as well as changes in intracellular macromolecules (represented by shading) would lead to shorter NAA T2.

WATER AND METABOLITE TRANSVERSE T2 RELAXATION TIME ABNORMALITIES IN THE WHITE MATTER IN SCHIZOPHRENIA

Schizophr Res. 2012 May;137(1-3):241-245.
Figure 5

Electron micrographs of white matter from control brain (a) and from the brains of subjects with schizophrenia (b–d). Both thinly myelinated (b, c) and axons with focal lysis of myelin sheath (d) as well as some axons with abnormally thick myelin sheaths (Figure 1(b)) were observed in schizophrenia in contrast to controls. Ap: astrocytic process, Mg: microglial cell. Ol: oligodendrocyte. Scale bars = 2 μm.

Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study

Schizophr Res Treatment. 2011;2011:325789.

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Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia. [PLoS One. 2012]
Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia.
Matthews PR, Eastwood SL, Harrison PJ. PLoS One. 2012; 7(6):e38211. Epub 2012 Jun 1.
White matter changes in schizophrenia: evidence for myelin-related dysfunction. [Arch Gen Psychiatry. 2003]
White matter changes in schizophrenia: evidence for myelin-related dysfunction.
Davis KL, Stewart DG, Friedman JI, Buchsbaum M, Harvey PD, Hof PR, Buxbaum J, Haroutunian V. Arch Gen Psychiatry. 2003 May; 60(5):443-56.
Myelin, copper, and the cuprizone model of schizophrenia. [Front Biosci (Schol Ed). 2011]
Myelin, copper, and the cuprizone model of schizophrenia.
Herring NR, Konradi C. Front Biosci (Schol Ed). 2011 Jan 1; 3:23-40. Epub 2011 Jan 1.

68 free full-text articles in PubMed Central

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques. [Front Integr Neurosci. 2013]
Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques.
Du F, Ongür D. Front Integr Neurosci. 2013; 7:24. Epub 2013 Apr 11.
What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia. [Front Integr Neurosci. 2013]
What does anisotropy measure? Insights from increased and decreased anisotropy in selective fiber tracts in schizophrenia.
Alba-Ferrara LM, de Erausquin GA. Front Integr Neurosci. 2013; 7:9. Epub 2013 Mar 11.
Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia. [PLoS One. 2013]
Discovery, validation and characterization of Erbb4 and Nrg1 haplotypes using data from three genome-wide association studies of schizophrenia.
Agim ZS, Esendal M, Briollais L, Uyan O, Meschian M, Martinez LA, Ding Y, Basak AN, Ozcelik H. PLoS One. 2013; 8(1):e53042. Epub 2013 Jan 3.