Zhonghua Gan Zang Bing Za Zhi. 2007 Nov;15(11):825-7.

[Effect of epigallocatechin-3-gallate on the invasiveness of hepatocarcinoma cells in vitro].

[Article in Chinese]

Lu L, Liu HM, Tang WX.

Source

Hangzhou No. 6 Hospital, China. luli7711@163.com

Abstract

OBJECTIVE:

The effect of EGCG on the invasion of HepG2 cells in vitro was studied.

METHODS:

The expressions of MUC1 in HepG2 cells before and after they were treated with EGCG were studied with immunohistochemistry. The effects of EGCG on the invasion of HepG2 cells were evaluated using Transwell chambers attached with polycarbonate filters and reconstituted basement membranes (Matrigel). Gelatin zymography was performed to detect the secretion of MMP-2 and MMP-9.

RESULTS:

EGCG reduced the expression of MUC1, suppressed significantly the invasion of tumor cells into the basement membranes (P < 0.01) and reduced the secretion of MMP-2, MMP-9.

CONCLUSION:

EGCG has anti-invasion effects on HepG2 cells.

PMID:: 18357659; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Liver Cancer - MedlinePlus Health Information

Supplemental Content

Related citations

Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator. [J Oral Pathol Med. 2007]
Epigallocatechin-3-gallate inhibits the invasion of human oral cancer cells and decreases the productions of matrix metalloproteinases and urokinase-plasminogen activator.
Ho YC, Yang SF, Peng CY, Chou MY, Chang YC. J Oral Pathol Med. 2007 Nov; 36(10):588-93.
Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7. [Life Sci. 2009]
Multifunctional effect of epigallocatechin-3-gallate (EGCG) in downregulation of gelatinase-A (MMP-2) in human breast cancer cell line MCF-7.
Sen T, Moulik S, Dutta A, Choudhury PR, Banerji A, Das S, Roy M, Chatterjee A. Life Sci. 2009 Feb 13; 84(7-8):194-204. Epub 2008 Dec 3.
Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells. [Ann N Y Acad Sci. 2007]
Phenolic phytochemicals derived from red pine (Pinus densiflora) inhibit the invasion and migration of SK-Hep-1 human hepatocellular carcinoma cells.
Lee SJ, Lee KW, Hur HJ, Chun JY, Kim SY, Lee HJ. Ann N Y Acad Sci. 2007 Jan; 1095:536-44.
Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cells. [Arch Biochem Biophys. 2002]
Enhanced expression of matrix metalloproteinase-9 by hepatitis B virus infection in liver cells.
Chung TW, Moon SK, Lee YC, Kim JG, Ko JH, Kim CH. Arch Biochem Biophys. 2002 Dec 15; 408(2):147-54.
Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. [Cancer. 2001]
Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate.
Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R, Albini A. Cancer. 2001 Feb 15; 91(4):822-32.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Search details

Recent activity

Clear Turn Off Turn On

[Effect of epigallocatechin-3-gallate on the invasiveness of hepatocarcinoma cel...
[Effect of epigallocatechin-3-gallate on the invasiveness of hepatocarcinoma cells in vitro].
Zhonghua Gan Zang Bing Za Zhi. 2007 Nov ;15(11):825-7.

PubMed
muc1 EGCG (1)
PubMed
Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity
Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity
NIHPA Author Manuscripts. 2009 Nov 4; 85(19-20): 663-669.

PMC
Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, wh...
Oncogenic RAS mutations in myeloma cells selectively induce cox-2 expression, which participates in enhanced adhesion to fibronectin and chemoresistance
Blood. 2006 Jun 1; 107(11): 4484-4490.

PMC
MUC1-C ONCOPROTEIN FUNCTIONS AS A DIRECT ACTIVATOR OF THE NF-κB p65 TRANSCRIPTIO...
MUC1-C ONCOPROTEIN FUNCTIONS AS A DIRECT ACTIVATOR OF THE NF-κB p65 TRANSCRIPTION FACTOR
NIHPA Author Manuscripts. 2009 Sep 1; 69(17): 7013-7021.

PMC

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

[Effect of epigallocatechin-3-gallate on the invasiveness of hepatocarcinoma cells in vitro].

Source

Abstract

OBJECTIVE:

METHODS:

RESULTS:

CONCLUSION:

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Medical

Supplemental Content

Related citations

Related information

Search details

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information