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Year Number of Results
2012 1
2014 5
2015 7
2016 1
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The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation.
Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA. Lesiak A, et al. J Neurosci. 2014 Jan 15;34(3):717-25. doi: 10.1523/JNEUROSCI.2884-13.2014. J Neurosci. 2014. PMID: 24431430 Free PMC article.
Nanomolar concentrations of PCB 95, a NDL congener with potent RyR activity, significantly increased spine density and the frequency of miniature EPSCs in primary dissociated rat hippocampal cultures coincident with upregulation of miR132. Inhibition of RyR, CREB, or mi …
Nanomolar concentrations of PCB 95, a NDL congener with potent RyR activity, significantly increased spine density and the frequency of mini …
Neuronal Development-Related miRNAs as Biomarkers for Alzheimer's Disease, Depression, Schizophrenia and Ionizing Radiation Exposure.
Segaran RC, Chan LY, Wang H, Sethi G, Tang FR. Segaran RC, et al. Curr Med Chem. 2021;28(1):19-52. doi: 10.2174/0929867327666200121122910. Curr Med Chem. 2021. PMID: 31965936 Review.
In the brain tissue, blood, or cerebral spinal fluid (CSF), 11, 55, or 28 miRNAs are involved in the development of AD respectively, 89, 50, 19 miRNAs in depression, and 102, 35, 8 miRNAs in schizophrenia. We compared miRNAs regulating neuronal development to those involve …
In the brain tissue, blood, or cerebral spinal fluid (CSF), 11, 55, or 28 miRNAs are involved in the development of AD respectively, 89, 50, …
Advances in Roles of miR-132 in the Nervous System.
Qian Y, Song J, Ouyang Y, Han Q, Chen W, Zhao X, Xie Y, Chen Y, Yuan W, Fan C. Qian Y, et al. Front Pharmacol. 2017 Oct 25;8:770. doi: 10.3389/fphar.2017.00770. eCollection 2017. Front Pharmacol. 2017. PMID: 29118714 Free PMC article. Review.
The dysregulation of miR-132 results in the occurrence and exacerbation of neural developmental, degenerative diseases, like Alzheimer's disease, Parkinson's disease and epilepsy, neural infection and psychiatric disorders including disturbance of consciousness, cognition and mem …
The dysregulation of miR-132 results in the occurrence and exacerbation of neural developmental, degenerative diseases, like Alzheimer's dis …
miRNAs as potential diagnostic biomarkers and pharmacogenomic indicators in psychiatric disorders.
Tsermpini EE, Kalogirou CI, Kyriakopoulos GC, Patrinos GP, Stathopoulos C. Tsermpini EE, et al. Pharmacogenomics J. 2022 Jul;22(4):211-222. doi: 10.1038/s41397-022-00283-7. Epub 2022 Jun 20. Pharmacogenomics J. 2022. PMID: 35725816 Review.
We provide herein a detailed overview of circulating miRNAs and their expression profiles as biomarkers in schizophrenia, bipolar disorder and major depressive disorder and their role in response to specific treatments. ...
We provide herein a detailed overview of circulating miRNAs and their expression profiles as biomarkers in schizophrenia, bipolar dis …
Association study of H2AFZ with schizophrenia in a Japanese case-control sample.
Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T. Jitoku D, et al. J Neural Transm (Vienna). 2015 Jun;122(6):915-23. doi: 10.1007/s00702-014-1332-x. Epub 2014 Nov 13. J Neural Transm (Vienna). 2015. PMID: 25392085
We did not detect any significant genetic association of these SNPs with schizophrenia in this cohort. However, we observed a significant association of SNP02 (rs2276939) in the male patients with schizophrenia (allelic P = 0.003, genotypic P = 0.008). ...The presen …
We did not detect any significant genetic association of these SNPs with schizophrenia in this cohort. However, we observed a signifi …
A preliminary analysis of microRNA as potential clinical biomarker for schizophrenia.
Sun XY, Zhang J, Niu W, Guo W, Song HT, Li HY, Fan HM, Zhao L, Zhong AF, Dai YH, Guo ZM, Zhang LY, Lu J, Zhang QL. Sun XY, et al. Am J Med Genet B Neuropsychiatr Genet. 2015 Apr;168B(3):170-8. doi: 10.1002/ajmg.b.32292. Epub 2015 Feb 5. Am J Med Genet B Neuropsychiatr Genet. 2015. PMID: 25656957
MicroRNAs (miRNA, miR) have been implicated as promising blood-based biomarkers for schizophrenia patients. This study aimed to clinically validate miRNA as potential schizophrenia biomarkers. ...We conclude that miR-30e, miR-181b, miR-34a, miR-346 and miR-7 combine …
MicroRNAs (miRNA, miR) have been implicated as promising blood-based biomarkers for schizophrenia patients. This study aimed to clini …
MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function.
Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C. Miller BH, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3125-30. doi: 10.1073/pnas.1113793109. Epub 2012 Feb 6. Proc Natl Acad Sci U S A. 2012. PMID: 22315408 Free PMC article.
Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. ...The cyclic AMP-responsive element binding- and NMDA-regulated microRNA miR-132 was significantly down-regulated in both the …
Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopm …
EZH1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia.
Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C. Johnstone AL, et al. Neurobiol Dis. 2018 Nov;119:149-158. doi: 10.1016/j.nbd.2018.08.005. Epub 2018 Aug 9. Neurobiol Dis. 2018. PMID: 30099093
Here, we aimed to identify novel epigenetic targets of the schizophrenia-associated microRNA 132 (miR-132). METHODS: Histone modifications were quantified by immunodetection in response to viral-mediated overexpression of miR-132 while a luminescent reporter system was use …
Here, we aimed to identify novel epigenetic targets of the schizophrenia-associated microRNA 132 (miR-132). METHODS: Histone modifica …
Aberrant microRNA expression in peripheral plasma and mononuclear cells as specific blood-based biomarkers in schizophrenia patients.
Sun XY, Lu J, Zhang L, Song HT, Zhao L, Fan HM, Zhong AF, Niu W, Guo ZM, Dai YH, Chen C, Ding YF, Zhang LY. Sun XY, et al. J Clin Neurosci. 2015 Mar;22(3):570-4. doi: 10.1016/j.jocn.2014.08.018. Epub 2014 Dec 6. J Clin Neurosci. 2015. PMID: 25487174
Findings from multiple studies on microRNA (miRNA) expression profiling in schizophrenia patients have produced conflicting results. In order to investigate miRNA as specific biomarkers in the peripheral plasma and peripheral blood mononuclear cells (PBMC) of schizophre …
Findings from multiple studies on microRNA (miRNA) expression profiling in schizophrenia patients have produced conflicting results. …
Non-coding RNA dysregulation in the amygdala region of schizophrenia patients contributes to the pathogenesis of the disease.
Liu Y, Chang X, Hahn CG, Gur RE, Sleiman PAM, Hakonarson H. Liu Y, et al. Transl Psychiatry. 2018 Feb 2;8(1):44. doi: 10.1038/s41398-017-0030-5. Transl Psychiatry. 2018. PMID: 29391398 Free PMC article.
Schizophrenia (SCZ) is a neuropsychiatric disorder with a complex genetic etiology. ...
Schizophrenia (SCZ) is a neuropsychiatric disorder with a complex genetic etiology. ...
20 results