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Results: 1 to 20 of 246

1.

Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence.

Zelent B, Raimondo A, Barrett A, Buettger CW, Chen P, Gloyn AL, Matschinsky FM.

Biochem J. 2014 May 1;459(3):551-64. doi: 10.1042/BJ20131363.

PMID:
24568320
[PubMed - indexed for MEDLINE]
2.

Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.

Roat R, Rao V, Doliba NM, Matschinsky FM, Tobias JW, Garcia E, Ahima RS, Imai Y.

PLoS One. 2014 Feb 5;9(2):e86815. doi: 10.1371/journal.pone.0086815. eCollection 2014.

PMID:
24505268
[PubMed - in process]
Free PMC Article
3.

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators.

Szlyk B, Braun CR, Ljubicic S, Patton E, Bird GH, Osundiji MA, Matschinsky FM, Walensky LD, Danial NN.

Nat Struct Mol Biol. 2014 Jan;21(1):36-42. doi: 10.1038/nsmb.2717. Epub 2013 Dec 8.

PMID:
24317490
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Metabolic signaling in fuel-induced insulin secretion.

Prentki M, Matschinsky FM, Madiraju SR.

Cell Metab. 2013 Aug 6;18(2):162-85. doi: 10.1016/j.cmet.2013.05.018. Epub 2013 Jun 20. Review.

PMID:
23791483
[PubMed - indexed for MEDLINE]
Free Article
5.

GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?

Matschinsky FM.

Trends Pharmacol Sci. 2013 Feb;34(2):90-9. doi: 10.1016/j.tips.2012.11.007. Epub 2013 Jan 7.

PMID:
23305809
[PubMed - indexed for MEDLINE]
6.

Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.

Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.

J Biol Chem. 2013 Feb 8;288(6):3938-51. doi: 10.1074/jbc.M112.385682. Epub 2012 Dec 24.

PMID:
23266825
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Repair of diverse diabetic defects of β-cells in man and mouse by pharmacological glucokinase activation.

Doliba NM, Fenner D, Zelent B, Bass J, Sarabu R, Matschinsky FM.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:109-19. doi: 10.1111/j.1463-1326.2012.01652.x. Review.

PMID:
22928571
[PubMed - indexed for MEDLINE]
8.

GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation.

Negahdar M, Aukrust I, Johansson BB, Molnes J, Molven A, Matschinsky FM, Søvik O, Kulkarni RN, Flatmark T, Njølstad PR, Bjørkhaug L.

Biochim Biophys Acta. 2012 Nov;1822(11):1705-15. doi: 10.1016/j.bbadis.2012.07.005. Epub 2012 Jul 20.

PMID:
22820548
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.

Sarabu R, Bizzarro FT, Corbett WL, Dvorozniak MT, Geng W, Grippo JF, Haynes NE, Hutchings S, Garofalo L, Guertin KR, Hilliard DW, Kabat M, Kester RF, Ka W, Liang Z, Mahaney PE, Marcus L, Matschinsky FM, Moore D, Racha J, Radinov R, Ren Y, Qi L, Pignatello M, Spence CL, Steele T, Tengi J, Grimsby J.

J Med Chem. 2012 Aug 23;55(16):7021-36. doi: 10.1021/jm3008689. Epub 2012 Aug 1.

PMID:
22809456
[PubMed - indexed for MEDLINE]
10.

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics.

Nissim I, Horyn O, Nissim I, Daikhin Y, Wehrli SL, Yudkoff M, Matschinsky FM.

Biochem J. 2012 Jun 15;444(3):537-51. doi: 10.1042/BJ20120163.

PMID:
22448977
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Thermal stability of glucokinase (GK) as influenced by the substrate glucose, an allosteric glucokinase activator drug (GKA) and the osmolytes glycerol and urea.

Zelent B, Buettger C, Grimsby J, Sarabu R, Vanderkooi JM, Wand AJ, Matschinsky FM.

Biochim Biophys Acta. 2012 May;1824(5):769-84. doi: 10.1016/j.bbapap.2012.03.003. Epub 2012 Mar 16.

PMID:
22446163
[PubMed - indexed for MEDLINE]
Free Article
12.

Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.

Cullen KS, Matschinsky FM, Agius L, Arden C.

Diabetes. 2011 Dec;60(12):3175-85. doi: 10.2337/db11-0423. Epub 2011 Oct 25.

PMID:
22028181
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Doliba NM, Qin W, Najafi H, Liu C, Buettger CW, Sotiris J, Collins HW, Li C, Stanley CA, Wilson DF, Grimsby J, Sarabu R, Naji A, Matschinsky FM.

Am J Physiol Endocrinol Metab. 2012 Jan 1;302(1):E87-E102. doi: 10.1152/ajpendo.00218.2011. Epub 2011 Sep 27.

PMID:
21952036
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.

Fenner D, Odili S, Hong HK, Kobayashi Y, Kohsaka A, Siepka SM, Vitaterna MH, Chen P, Zelent B, Grimsby J, Takahashi JS, Matschinsky FM, Bass J.

J Biol Chem. 2011 Nov 11;286(45):39560-72. doi: 10.1074/jbc.M111.269100. Epub 2011 Sep 15.

PMID:
21921030
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Mutational analysis of allosteric activation and inhibition of glucokinase.

Zelent B, Odili S, Buettger C, Zelent DK, Chen P, Fenner D, Bass J, Stanley C, Laberge M, Vanderkooi JM, Sarabu R, Grimsby J, Matschinsky FM.

Biochem J. 2011 Dec 1;440(2):203-15. doi: 10.1042/BJ20110440.

PMID:
21831042
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Green tea polyphenols control dysregulated glutamate dehydrogenase in transgenic mice by hijacking the ADP activation site.

Li C, Li M, Chen P, Narayan S, Matschinsky FM, Bennett MJ, Stanley CA, Smith TJ.

J Biol Chem. 2011 Sep 30;286(39):34164-74. doi: 10.1074/jbc.M111.268599. Epub 2011 Aug 3.

PMID:
21813650
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Glucokinase activators for diabetes therapy: May 2010 status report.

Matschinsky FM, Zelent B, Doliba N, Li C, Vanderkooi JM, Naji A, Sarabu R, Grimsby J.

Diabetes Care. 2011 May;34 Suppl 2:S236-43. doi: 10.2337/dc11-s236. No abstract available.

PMID:
21525462
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects.

Matschinsky FM, Zelent B, Doliba NM, Kaestner KH, Vanderkooi JM, Grimsby J, Berthel SJ, Sarabu R.

Handb Exp Pharmacol. 2011;(203):357-401. doi: 10.1007/978-3-642-17214-4_15. Review.

PMID:
21484579
[PubMed - indexed for MEDLINE]
19.

Glucokinase activators (GKAs) promise a new pharmacotherapy for diabetics.

Matschinsky FM, Porte D.

F1000 Med Rep. 2010 Jun 16;2. pii: 43. doi: 10.3410/M2-43.

PMID:
20948841
[PubMed]
Free PMC Article
20.

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA.

J Biol Chem. 2010 Oct 8;285(41):31806-18. doi: 10.1074/jbc.M110.123638. Epub 2010 Jul 29.

PMID:
20670938
[PubMed - indexed for MEDLINE]
Free PMC Article

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