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Results: 1 to 20 of 23

1.

The endothelial protein C receptor enhances hemostasis of FVIIa administration in hemophilic mice in vivo.

Pavani G, Ivanciu L, Faella A, Marcos-Contreras OA, Margaritis P.

Blood. 2014 Aug 14;124(7):1157-65. doi: 10.1182/blood-2014-04-567297. Epub 2014 Jun 23.

PMID:
24957146
[PubMed - in process]
Free PMC Article
2.

An engineered U1 small nuclear RNA rescues splicing defective coagulation F7 gene expression in mice.

Balestra D, Faella A, Margaritis P, Cavallari N, Pagani F, Bernardi F, Arruda VR, Pinotti M.

J Thromb Haemost. 2014 Feb;12(2):177-85.

PMID:
24738135
[PubMed - indexed for MEDLINE]
3.

An engineered U1 small nuclear RNA rescues splicing-defective coagulation F7 gene expression in mice.

Balestra D, Faella A, Margaritis P, Cavallari N, Pagani F, Bernardi F, Arruda VR, Pinotti M.

J Thromb Haemost. 2014 Feb;12(2):177-185. doi: 10.1111/jth.12471.

PMID:
24735116
[PubMed - as supplied by publisher]
Free PMC Article
4.

Does rFVIIa work solo in hemophilia?

Margaritis P.

Blood. 2014 Mar 13;123(11):1631-3. doi: 10.1182/blood-2014-01-551275. No abstract available.

PMID:
24627522
[PubMed - indexed for MEDLINE]
5.

Cellular localization and characterization of cytosolic binding partners for Gla domain-containing proteins PRRG4 and PRRG2.

Yazicioglu MN, Monaldini L, Chu K, Khazi FR, Murphy SL, Huang H, Margaritis P, High KA.

J Biol Chem. 2013 Sep 6;288(36):25908-14. doi: 10.1074/jbc.M113.484683. Epub 2013 Jul 19.

PMID:
23873930
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Gene-based continuous expression of FVIIa for the treatment of hemophilia.

Margaritis P.

Front Biosci (Schol Ed). 2012 Jan 1;4:287-99. Review.

PMID:
22202061
[PubMed - indexed for MEDLINE]
7.

ARFI ultrasound monitoring of hemorrhage and hemostasis in vivo in canine von Willebrand disease and hemophilia.

Scola MR, Nichols TC, Zhu H, Caughey MC, Merricks EP, Raymer RA, Margaritis P, High KA, Gallippi CM.

Ultrasound Med Biol. 2011 Dec;37(12):2126-32. doi: 10.1016/j.ultrasmedbio.2011.09.006. Epub 2011 Oct 26.

PMID:
22033127
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia.

Ivanciu L, Toso R, Margaritis P, Pavani G, Kim H, Schlachterman A, Liu JH, Clerin V, Pittman DD, Rose-Miranda R, Shields KM, Erbe DV, Tobin JF, Arruda VR, Camire RM.

Nat Biotechnol. 2011 Oct 23;29(11):1028-33. doi: 10.1038/nbt.1995.

PMID:
22020385
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Mutation in the factor VII hepatocyte nuclear factor 4α-binding site contributes to factor VII deficiency.

Zheng XW, Kudaravalli R, Russell TT, DiMichele DM, Gibb C, Russell JE, Margaritis P, Pollak ES.

Blood Coagul Fibrinolysis. 2011 Oct;22(7):624-7. doi: 10.1097/MBC.0b013e3283497699.

PMID:
21760481
[PubMed - indexed for MEDLINE]
10.

Catalytic domain modification and viral gene delivery of activated factor VII confers hemostasis at reduced expression levels and vector doses in vivo.

Margaritis P, Roy E, Faella A, Downey HD, Ivanciu L, Pavani G, Zhou S, Bunte RM, High KA.

Blood. 2011 Apr 14;117(15):3974-82. doi: 10.1182/blood-2010-09-309732. Epub 2011 Feb 16. Erratum in: Blood. 2012 May 10;119(19):4577.

PMID:
21325603
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Gene therapy in haemophilia--going for cure?

Margaritis P, High KA.

Haemophilia. 2010 May;16 Suppl 3:24-8. doi: 10.1111/j.1365-2516.2010.02256.x. Review.

PMID:
20586798
[PubMed - indexed for MEDLINE]
12.

Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B.

Nichols TC, Raymer RA, Franck HW, Merricks EP, Bellinger DA, DeFriess N, Margaritis P, Arruda VR, Kay MA, High KA.

Haemophilia. 2010 May;16 Suppl 3:19-23. doi: 10.1111/j.1365-2516.2010.02255.x. Review.

PMID:
20586797
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Long-term expression of canine FVIIa in hemophilic dogs.

Margaritis P.

Thromb Res. 2010 Apr;125 Suppl 1:S60-2. doi: 10.1016/j.thromres.2010.01.040. Epub 2010 Feb 10. Review.

PMID:
20149416
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Successful treatment of canine hemophilia by continuous expression of canine FVIIa.

Margaritis P, Roy E, Aljamali MN, Downey HD, Giger U, Zhou S, Merricks E, Dillow A, Ezban M, Nichols TC, High KA.

Blood. 2009 Apr 16;113(16):3682-9. doi: 10.1182/blood-2008-07-168377. Epub 2008 Dec 23.

PMID:
19109232
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Over-expression of factor VIIa in vivo.

Margaritis P.

Thromb Res. 2008;122 Suppl 1:S70-2. doi: 10.1016/S0049-3848(08)70023-9. Review.

PMID:
18691505
[PubMed - indexed for MEDLINE]
16.

Long-term expression of murine activated factor VII is safe, but elevated levels cause premature mortality.

Aljamali MN, Margaritis P, Schlachterman A, Tai SJ, Roy E, Bunte R, Camire RM, High KA.

J Clin Invest. 2008 May;118(5):1825-34. doi: 10.1172/JCI32878.

PMID:
18398505
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A viable mouse model of factor X deficiency provides evidence for maternal transfer of factor X.

Tai SJ, Herzog RW, Margaritis P, Arruda VR, Chu K, Golden JA, Labosky PA, High KA.

J Thromb Haemost. 2008 Feb;6(2):339-45. Epub 2007 Nov 23.

PMID:
18036190
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.

Yang C, Feng J, Song W, Wang J, Tsai B, Zhang Y, Scaringe WA, Hill KA, Margaritis P, High KA, Sommer SS.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15394-9. Epub 2007 Sep 19.

PMID:
17881586
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A novel missense mutation responsible for factor VII deficiency in research Beagle colonies.

Callan MB, Aljamali MN, Margaritis P, Griot-Wenk ME, Pollak ES, Werner P, Giger U, High KA.

J Thromb Haemost. 2006 Dec;4(12):2616-22. Epub 2006 Sep 8.

PMID:
16961583
[PubMed - indexed for MEDLINE]
20.

Advances in gene therapy using factor VIIa in hemophilia.

Margaritis P, High KA.

Semin Hematol. 2006 Jan;43(1 Suppl 1):S101-4. Review.

PMID:
16427374
[PubMed - indexed for MEDLINE]

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