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A Parkinsonian syndrome in methcathinone users and the role of manganese.
Stepens A, Logina I, Liguts V, Aldins P, Eksteina I, Platkājis A, Mārtinsone I, Tērauds E, Rozentāle B, Donaghy M. Stepens A, et al. N Engl J Med. 2008 Mar 6;358(10):1009-17. doi: 10.1056/NEJMoa072488. N Engl J Med. 2008. PMID: 18322282 Free article.
Among the 13 former users (2 to 6 years had passed since the last use), lesser degrees of change in the MRI signal were noted. Whole-blood manganese levels (normal level, <209 nmol per liter) averaged 831 nmol per liter (range, 201 to 2102) in the active methcathinone u …
Among the 13 former users (2 to 6 years had passed since the last use), lesser degrees of change in the MRI signal were noted. Whole-blood …
Cognitive profile of patients with manganese-methcathinone encephalopathy.
Ennok M, Sikk K, Haldre S, Taba P. Ennok M, et al. Neurotoxicology. 2020 Jan;76:138-143. doi: 10.1016/j.neuro.2019.10.007. Epub 2019 Oct 31. Neurotoxicology. 2020. PMID: 31678058
Manganese-methcathinone encephalopathy (MME) is a rare parkinsonian syndrome described in drug addicts who have self-injected a home-made mixture containing methcathinone and manganese. We assessed 14 patients with MME and compared their results with 14 match …
Manganese-methcathinone encephalopathy (MME) is a rare parkinsonian syndrome described in drug addicts who have self-injected …
Methcathinone "Kitchen Chemistry" and Permanent Neurological Damage.
Sikk K, Taba P. Sikk K, et al. Int Rev Neurobiol. 2015;120:257-71. doi: 10.1016/bs.irn.2015.02.002. Epub 2015 Mar 12. Int Rev Neurobiol. 2015. PMID: 26070761 Review.
The drug is synthesized from over-the-counter cold remedies containing ephedrine or pseudoephedrine. The final mixture contains a high concentration of manganese if potassium permanganate is used as the oxidant agent. Though manganese is an essential trace element a …
The drug is synthesized from over-the-counter cold remedies containing ephedrine or pseudoephedrine. The final mixture contains a high conce …
Neuropathological Findings in Ephedrone Encephalopathy.
Sanotsky Y, Selikhova M, Fedoryshyn L, Kuzyk P, Matviyenko Y, Semeryak O, Dziewulska D, Holton JL, Lees AJ. Sanotsky Y, et al. Mov Disord. 2020 Oct;35(10):1858-1863. doi: 10.1002/mds.28125. Epub 2020 Jun 16. Mov Disord. 2020. PMID: 32542919
CONCLUSIONS: Clinical findings of l-dopa-unresponsive parkinsonism with dystonia, caused by illicit use of ephedrone, are fully consistent with neuropathological changes in the pallidum, lack of change in the SN, and preserved tyrosine hydroxylase activity. The findings in the ba …
CONCLUSIONS: Clinical findings of l-dopa-unresponsive parkinsonism with dystonia, caused by illicit use of ephedrone, are fully consistent w …
Eye movements in ephedrone-induced parkinsonism.
Bonnet C, Rusz J, Megrelishvili M, Sieger T, Matoušková O, Okujava M, Brožová H, Nikolai T, Hanuška J, Kapianidze M, Mikeladze N, Botchorishvili N, Khatiashvili I, Janelidze M, Serranová T, Fiala O, Roth J, Bergquist J, Jech R, Rivaud-Péchoux S, Gaymard B, Růžička E. Bonnet C, et al. PLoS One. 2014 Aug 12;9(8):e104784. doi: 10.1371/journal.pone.0104784. eCollection 2014. PLoS One. 2014. PMID: 25117825 Free PMC article.
Patients with ephedrone parkinsonism (EP) show a complex, rapidly progressive, irreversible, and levodopa non-responsive parkinsonian and dystonic syndrome due to manganese intoxication. Eye movements may help to differentiate parkinsonian syndromes providing …
Patients with ephedrone parkinsonism (EP) show a complex, rapidly progressive, irreversible, and levodopa non-responsive parkinsonian …
Unusual magnetic resonance imaging of the head in manganese and ephedrone intoxication - a case report.
Jastrzębski K, Gałecki P, Sanchez SI. Jastrzębski K, et al. Pol Merkur Lekarski. 2021 Dec 16;49(294):434-436. Pol Merkur Lekarski. 2021. PMID: 34919088
Manganese intoxication leads to the accumulation of manganese in the brain, mostly in the globus pallidus, which clinically manifests as a L-DOPA - resistant parkinsonian syndrome with specific symptoms, such as spastic-hypokinetic dysarthria and postural ins …
Manganese intoxication leads to the accumulation of manganese in the brain, mostly in the globus pallidus, which clinically ma …
Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up.
Sikk K, Haldre S, Aquilonius SM, Asser A, Paris M, Roose Ä, Petterson J, Eriksson SL, Bergquist J, Taba P. Sikk K, et al. Eur J Neurol. 2013 Jun;20(6):915-20. doi: 10.1111/ene.12088. Epub 2013 Jan 24. Eur J Neurol. 2013. PMID: 23347399
Twenty-four cases were reassessed 9-70 (20 15) months after the initial evaluation. Manganese (Mn) in plasma and hair was analysed by inductively coupled plasma-atom emission spectrometry. ...
Twenty-four cases were reassessed 9-70 (20 15) months after the initial evaluation. Manganese (Mn) in plasma and hair was analysed by …
Grey matter abnormalities in methcathinone abusers with a Parkinsonian syndrome.
Juurmaa J, Menke RA, Vila P, Müürsepp A, Tomberg T, Ilves P, Nigul M, Johansen-Berg H, Donaghy M, Stagg CJ, Stepens A, Taba P. Juurmaa J, et al. Brain Behav. 2016 Aug 18;6(11):e00539. doi: 10.1002/brb3.539. eCollection 2016 Nov. Brain Behav. 2016. PMID: 27843694 Free PMC article.
BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weight …
BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone) …
Parkinsonism and dystonia caused by the illicit use of ephedrone--a longitudinal study.
Selikhova M, Fedoryshyn L, Matviyenko Y, Komnatska I, Kyrylchuk M, Krolicki L, Friedman A, Taylor A, Jäger HR, Lees A, Sanotsky Y. Selikhova M, et al. Mov Disord. 2008 Nov 15;23(15):2224-31. doi: 10.1002/mds.22290. Mov Disord. 2008. PMID: 18785245
The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were carried out. Pubic hair was sampled for manganese. The clinical and radiological picture closely resembled previous reports of chron …
The natural history, response to treatment, and clinical features has been studied, and MR and dopamine transporter SPECT brain imaging were …
21 results