Sort by

Send to

Choose Destination

Search results

Items: 1 to 20 of 33


A new view of transcriptome complexity and regulation through the lens of local splicing variations.

Vaquero-Garcia J, Barrera A, Gazzara MR, González-Vallinas J, Lahens NF, Hogenesch JB, Lynch KW, Barash Y.

Elife. 2016 Feb 1;5. pii: e11752. doi: 10.7554/eLife.11752.


Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy.

Sotillo E, Barrett DM, Black KL, Bagashev A, Oldridge D, Wu G, Sussman R, Lanauze C, Ruella M, Gazzara MR, Martinez NM, Harrington CT, Chung EY, Perazzelli J, Hofmann TJ, Maude SL, Raman P, Barrera A, Gill S, Lacey SF, Melenhorst JJ, Allman D, Jacoby E, Fry T, Mackall C, Barash Y, Lynch KW, Maris JM, Grupp SA, Thomas-Tikhonenko A.

Cancer Discov. 2015 Dec;5(12):1282-95. doi: 10.1158/2159-8290.CD-15-1020. Epub 2015 Oct 29.


Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation.

Martinez NM, Agosto L, Qiu J, Mallory MJ, Gazzara MR, Barash Y, Fu XD, Lynch KW.

Genes Dev. 2015 Oct 1;29(19):2054-66. doi: 10.1101/gad.267245.115.


TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells.

Yarosh CA, Tapescu I, Thompson MG, Qiu J, Mallory MJ, Fu XD, Lynch KW.

Nucleic Acids Res. 2015 Oct 15;43(18):9006-16. doi: 10.1093/nar/gkv816. Epub 2015 Aug 10.


Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T-cell signaling.

Mallory MJ, Allon SJ, Qiu J, Gazzara MR, Tapescu I, Martinez NM, Fu XD, Lynch KW.

Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2139-48. doi: 10.1073/pnas.1423695112. Epub 2015 Apr 13.


Thoughts on NGS, alternative splicing and what we still need to know.

Lynch KW.

RNA. 2015 Apr;21(4):683-4. doi: 10.1261/rna.050419.115. No abstract available.


Stem-loop recognition by DDX17 facilitates miRNA processing and antiviral defense.

Moy RH, Cole BS, Yasunaga A, Gold B, Shankarling G, Varble A, Molleston JM, tenOever BR, Lynch KW, Cherry S.

Cell. 2014 Aug 14;158(4):764-77. doi: 10.1016/j.cell.2014.06.023.


An optogenetic gene expression system with rapid activation and deactivation kinetics.

Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH.

Nat Chem Biol. 2014 Mar;10(3):196-202. doi: 10.1038/nchembio.1430. Epub 2014 Jan 12.


In silico to in vivo splicing analysis using splicing code models.

Gazzara MR, Vaquero-Garcia J, Lynch KW, Barash Y.

Methods. 2014 May 1;67(1):3-12. doi: 10.1016/j.ymeth.2013.11.006. Epub 2013 Dec 7.


Paralogs hnRNP L and hnRNP LL exhibit overlapping but distinct RNA binding constraints.

Smith SA, Ray D, Cook KB, Mallory MJ, Hughes TR, Lynch KW.

PLoS One. 2013 Nov 11;8(11):e80701. doi: 10.1371/journal.pone.0080701. eCollection 2013.


Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.

Shankarling G, Cole BS, Mallory MJ, Lynch KW.

Mol Cell Biol. 2014 Jan;34(1):71-83. doi: 10.1128/MCB.00740-13. Epub 2013 Oct 28.


A compendium of RNA-binding motifs for decoding gene regulation.

Ray D, Kazan H, Cook KB, Weirauch MT, Najafabadi HS, Li X, Gueroussov S, Albu M, Zheng H, Yang A, Na H, Irimia M, Matzat LH, Dale RK, Smith SA, Yarosh CA, Kelly SM, Nabet B, Mecenas D, Li W, Laishram RS, Qiao M, Lipshitz HD, Piano F, Corbett AH, Carstens RP, Frey BJ, Anderson RA, Lynch KW, Penalva LO, Lei EP, Fraser AG, Blencowe BJ, Morris QD, Hughes TR.

Nature. 2013 Jul 11;499(7457):172-7. doi: 10.1038/nature12311.


Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

Tsai PL, Chiou NT, Kuss S, García-Sastre A, Lynch KW, Fontoura BM.

PLoS Pathog. 2013;9(6):e1003460. doi: 10.1371/journal.ppat.1003460. Epub 2013 Jun 27.


Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn.

Martinez NM, Lynch KW.

Immunol Rev. 2013 May;253(1):216-36. doi: 10.1111/imr.12047. Review.


hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.

Vu NT, Park MA, Shultz JC, Goehe RW, Hoeferlin LA, Shultz MD, Smith SA, Lynch KW, Chalfant CE.

J Biol Chem. 2013 Mar 22;288(12):8575-84. doi: 10.1074/jbc.M112.443333. Epub 2013 Feb 8.


hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly.

Chiou NT, Shankarling G, Lynch KW.

Mol Cell. 2013 Mar 7;49(5):972-82. doi: 10.1016/j.molcel.2012.12.025. Epub 2013 Feb 7.


Alternative splicing networks regulated by signaling in human T cells.

Martinez NM, Pan Q, Cole BS, Yarosh CA, Babcock GA, Heyd F, Zhu W, Ajith S, Blencowe BJ, Lynch KW.

RNA. 2012 May;18(5):1029-40. doi: 10.1261/rna.032243.112. Epub 2012 Mar 27.


PSF controls expression of histone variants and cellular viability in thymocytes.

Heyd F, Lynch KW.

Biochem Biophys Res Commun. 2011 Nov 4;414(4):743-9. doi: 10.1016/j.bbrc.2011.09.149. Epub 2011 Oct 6.


Degrade, move, regroup: signaling control of splicing proteins.

Heyd F, Lynch KW.

Trends Biochem Sci. 2011 Aug;36(8):397-404. doi: 10.1016/j.tibs.2011.04.003. Epub 2011 May 17. Review.

Items per page

Supplemental Content

Loading ...
Write to the Help Desk