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Page 1
Dasatinib induces lung vascular toxicity and predisposes to pulmonary hypertension.
Guignabert C, Phan C, Seferian A, Huertas A, Tu L, Thuillet R, Sattler C, Le Hiress M, Tamura Y, Jutant EM, Chaumais MC, Bouchet S, Manéglier B, Molimard M, Rousselot P, Sitbon O, Simonneau G, Montani D, Humbert M. Guignabert C, et al. J Clin Invest. 2016 Sep 1;126(9):3207-18. doi: 10.1172/JCI86249. Epub 2016 Aug 2. J Clin Invest. 2016. PMID: 27482885 Free PMC article. Clinical Trial.
Here, we demonstrated that chronic dasatinib therapy causes pulmonary endothelial damage in humans and rodents. We found that dasatinib treatment attenuated hypoxic pulmonary vasoconstriction responses and increased susceptibility to experimental pulmonary …
Here, we demonstrated that chronic dasatinib therapy causes pulmonary endothelial damage in humans and rodents. We found that dasatin …
Recombinant hirudin attenuates pulmonary hypertension and thrombosis in acute pulmonary embolism rat model.
Wei X, Zou Y, Dong S, Chen Y, Li G, Wang B. Wei X, et al. PeerJ. 2024 Apr 5;12:e17039. doi: 10.7717/peerj.17039. eCollection 2024. PeerJ. 2024. PMID: 38590700 Free PMC article.
Moreover, R-hirudin ameliorated histopathological injuries and reduced apoptotic cells and Matrix metalloproteinase-9 (MMP9), vascular cell adhesion molecule-1 (VCAM-1), p-Extracellular signal-regulated kinase (ERK)1/2/ERK1/2, and p-P65/P65 expr …
Moreover, R-hirudin ameliorated histopathological injuries and reduced apoptotic cells and Matrix metalloproteinase-9 (MMP9), vascular …
Caveolin-1 expression during the progression of pulmonary hypertension.
Huang J, Wolk JH, Gewitz MH, Mathew R. Huang J, et al. Exp Biol Med (Maywood). 2012 Aug;237(8):956-65. doi: 10.1258/ebm.2012.011382. Epub 2012 Aug 13. Exp Biol Med (Maywood). 2012. PMID: 22890027
Caveolin-1 plays a pivotal role in maintaining vascular health. Progressive loss of endothelial caveolin-1 and activation of proliferative and anti-apoptotic pathways occur before the onset of monocrotaline (MCT)-induced pulmonary hypertension (PH), and the r …
Caveolin-1 plays a pivotal role in maintaining vascular health. Progressive loss of endothelial caveolin-1 and activation of prolifer …
Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2alpha.
Sun X, Sun BL, Babicheva A, Vanderpool R, Oita RC, Casanova N, Tang H, Gupta A, Lynn H, Gupta G, Rischard F, Sammani S, Kempf CL, Moreno-Vinasco L, Ahmed M, Camp SM, Wang J, Desai AA, Yuan JX, Garcia JGN. Sun X, et al. Am J Respir Cell Mol Biol. 2020 Jul;63(1):92-103. doi: 10.1165/rcmb.2019-0164OC. Am J Respir Cell Mol Biol. 2020. PMID: 32142369 Free PMC article.
We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (PAH) and now examine NAMPT regulation and extracellular NAMPT's (eNAMPT's) role in PAH vascular remodeling. ...Endothelial-to-mesenchy …
We previously demonstrated involvement of NAMPT (nicotinamide phosphoribosyltransferase) in pulmonary arterial hypertension (P …
Intralipid prevents and rescues fatal pulmonary arterial hypertension and right ventricular failure in rats.
Umar S, Nadadur RD, Li J, Maltese F, Partownavid P, van der Laarse A, Eghbali M. Umar S, et al. Hypertension. 2011 Sep;58(3):512-8. doi: 10.1161/HYPERTENSIONAHA.110.168781. Epub 2011 Jul 11. Hypertension. 2011. PMID: 21747043 Free PMC article.
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular (RV) hypertrophy and failure. ...Therapy with ILP resulted in 100% survival and prevented PAH-induced RV failure by preserving RV press …
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventric …
Sildenafil stimulates and dexamethasone inhibits pulmonary vascular development in congenital diaphragmatic hernia rat lungs.
Kattan J, Céspedes C, González A, Vio CP. Kattan J, et al. Neonatology. 2014;106(1):74-80. doi: 10.1159/000358226. Epub 2014 May 10. Neonatology. 2014. PMID: 24819293
BACKGROUND: A predictor of neonatal mortality in infants with congenital diaphragmatic hernia (CDH) is disrupted pulmonary vascular development, clinically expressed as pulmonary hypertension. OBJECTIVE: To determine if prenatal corticosteroids and pho …
BACKGROUND: A predictor of neonatal mortality in infants with congenital diaphragmatic hernia (CDH) is disrupted pulmonary vascula …
Vascular endothelial-cadherin downregulation as a feature of endothelial transdifferentiation in monocrotaline-induced pulmonary hypertension.
Nikitopoulou I, Orfanos SE, Kotanidou A, Maltabe V, Manitsopoulos N, Karras P, Kouklis P, Armaganidis A, Maniatis NA. Nikitopoulou I, et al. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L352-63. doi: 10.1152/ajplung.00156.2014. Epub 2016 May 27. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27233997 Free article.
Increased pulmonary vascular resistance in pulmonary hypertension (PH) is caused by vasoconstriction and obstruction of small pulmonary arteries by proliferating vascular cells. ...Mesenchymal markers alpha-smooth muscle actin and vimenti …
Increased pulmonary vascular resistance in pulmonary hypertension (PH) is caused by vasoconstriction and obstruc …
Hepcidin protects pulmonary artery hypertension in rats by activating NF-kappaB/TNF-alpha pathway.
Liu WY, Wang L, Lai YF. Liu WY, et al. Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7573-7581. doi: 10.26355/eurrev_201909_18878. Eur Rev Med Pharmacol Sci. 2019. PMID: 31539149 Free article.
OBJECTIVE: The pulmonary artery hypertension (PAH) model was established in rats in this study. ...Finally, Western blot was conducted to detect the protein expressions of nuclear factor-kappa B (NF-kappaB), tumor necrosis factor-alpha (TNF-alpha), interleuki …
OBJECTIVE: The pulmonary artery hypertension (PAH) model was established in rats in this study. ...Finally, Western blo …
Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium.
Blair LA, Haven AK, Bauer NN. Blair LA, et al. Respir Res. 2016 Oct 20;17(1):133. doi: 10.1186/s12931-016-0445-1. Respir Res. 2016. PMID: 27765042 Free PMC article.
BACKGROUND: Microparticles (MPs) stimulate inflammatory adhesion molecule expression in systemic vascular diseases, however it is unknown whether circulating MPs stimulate localized ICAM-1 expression in the heterogeneically distinct pulmonary endothelium duri …
BACKGROUND: Microparticles (MPs) stimulate inflammatory adhesion molecule expression in systemic vascular diseases, however it …
Transplantation of Mesenchymal Stem Cells Attenuates Pulmonary Hypertension by Normalizing the Endothelial-to-Mesenchymal Transition.
Huang J, Lu W, Ouyang H, Chen Y, Zhang C, Luo X, Li M, Shu J, Zheng Q, Chen H, Chen J, Tang H, Sun D, Yuan JX, Yang K, Wang J. Huang J, et al. Am J Respir Cell Mol Biol. 2020 Jan;62(1):49-60. doi: 10.1165/rcmb.2018-0165OC. Am J Respir Cell Mol Biol. 2020. PMID: 31211918 Free PMC article.
For decades, stem cell therapies for pulmonary hypertension (PH) have progressed from laboratory hypothesis to clinical practice. ...Then, MSCs significantly attenuated the hypoxia-induced EndMT in both the lungs of PH models and primary cultured rat pulmo …
For decades, stem cell therapies for pulmonary hypertension (PH) have progressed from laboratory hypothesis to clinical …
27 results