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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1902 1
1957 1
1963 1
1964 2
1966 4
1968 1
1970 1
1971 2
1972 4
1973 1
1974 5
1975 3
1976 2
1977 3
1978 3
1980 1
1981 3
1982 4
1983 2
1985 3
1986 5
1987 8
1988 6
1989 4
1990 5
1991 7
1992 9
1993 16
1994 12
1995 27
1996 18
1997 35
1998 33
1999 37
2000 45
2001 49
2002 48
2003 60
2004 44
2005 70
2006 73
2007 69
2008 85
2009 72
2010 79
2011 90
2012 99
2013 92
2014 109
2015 95
2016 94
2017 120
2018 120
2019 118
2020 116
2021 109
2022 123
2023 116
2024 36

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2,178 results

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Page 1
Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress.
Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV. Liu X, et al. Nat Cancer. 2022 Jul;3(7):866-884. doi: 10.1038/s43018-022-00389-8. Epub 2022 Jun 2. Nat Cancer. 2022. PMID: 35654861 Free PMC article.
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-41) that binds LIPA …
Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosoma …
Novel LIPA-Targeted Therapy for Treating Ovarian Cancer.
Collier AB, Viswanadhapalli S, Gopalam R, Lee TK, Kassees K, Parra K, Sharma G, Reese TC, Liu X, Yang X, Ebrahimi B, Pratap UP, Mahajan M, Arnold WC, Baker A, Chen CY, Elmore ST, Subbarayalu P, Sareddy GR, Valente PT, Kost ER, Ahn JM, Vadlamudi RK. Collier AB, et al. Cancers (Basel). 2024 Jan 24;16(3):500. doi: 10.3390/cancers16030500. Cancers (Basel). 2024. PMID: 38339252 Free PMC article.
However, the role of LIPA and theutility of ERX-41 to treat OCa remain unknown. Expression analysis using the TNMplot web tool, TCGA data sets, and immunohistochemistry analysis using a tumor tissue array showed that LIPA is highly expressed in OCa tissues, compared …
However, the role of LIPA and theutility of ERX-41 to treat OCa remain unknown. Expression analysis using the TNMplot web tool, TCGA …
LIPA gene mutations affect the composition of lipoproteins: Enrichment in ACAT-derived cholesteryl esters.
Arnaboldi L, Ossoli A, Giorgio E, Pisciotta L, Lucchi T, Grigore L, Pavanello C, Granata A, Pasta A, Arosio B, Azzolino D, Baragetti A, Castelnuovo S, Corsini A, Catapano AL, Calabresi L, Gomaraschi M. Arnaboldi L, et al. Atherosclerosis. 2020 Mar;297:8-15. doi: 10.1016/j.atherosclerosis.2020.01.026. Epub 2020 Jan 31. Atherosclerosis. 2020. PMID: 32058863 Free article.
Further insights into the impact of LIPA gene mutations on lipid/lipoprotein metabolism are limited. Aim of the study was to investigate the effect of carrying one or two mutant LIPA alleles on lipoprotein composition and function. METHODS: Lipoproteins were isolate …
Further insights into the impact of LIPA gene mutations on lipid/lipoprotein metabolism are limited. Aim of the study was to investig …
First LIPA Mutational Analysis in Egyptian Patients Reveals One Novel Variant: Wolman Disease.
Elaraby NM, Galal ER, Abdel-Hamid M, Elbendary HM, Elbadry M, Mekkawy MK, Ashaat NA, Mounir SM, Ashaat EA. Elaraby NM, et al. J Mol Neurosci. 2023 Aug;73(7-8):598-607. doi: 10.1007/s12031-023-02139-6. Epub 2023 Jul 20. J Mol Neurosci. 2023. PMID: 37470904 Free PMC article.
Lysosomal acid lipase (LAL) is a necessary enzyme for the hydrolysis of both triglycerides (TGs) and cholesteryl esters (CEs) in the lysosome. Deficiency of this enzyme encoded by the lipase A (LIPA) gene leads to LAL deficiency (LAL-D). A severe disease subtype of LAL-D i …
Lysosomal acid lipase (LAL) is a necessary enzyme for the hydrolysis of both triglycerides (TGs) and cholesteryl esters (CEs) in the lysosom …
Wolman disease presenting with hemophagocytic lymphohistiocytosis syndrome and a novel LIPA gene variant: a case report and review of the literature.
Asna Ashari K, Azari-Yam A, Shahrooei M, Ziaee V. Asna Ashari K, et al. J Med Case Rep. 2023 Aug 29;17(1):369. doi: 10.1186/s13256-023-04116-4. J Med Case Rep. 2023. PMID: 37641143 Free PMC article. Review.
BACKGROUND: Wolman disease is a rare disease caused by the absence of functional liposomal acid lipase due to mutations in LIPA gene. It presents with organomegaly, malabsorption, and adrenal calcifications. ...The genetic analysis revealed after his demise was compatible …
BACKGROUND: Wolman disease is a rare disease caused by the absence of functional liposomal acid lipase due to mutations in LIPA gene. …
Study on the bio-function of lipA gene in Aspergillus flavus.
Bai W, Feng T, Lan F, Lin G, Li Y, Fasoyin OE, Liu Y, Jia K. Bai W, et al. Genes Genomics. 2019 Jan;41(1):107-111. doi: 10.1007/s13258-018-0744-7. Epub 2018 Sep 27. Genes Genomics. 2019. PMID: 30264213
LipA coding lipoic acid synthetase was knocked out using homologous recombination. ...The growth was suppressed in lipA. The formation of conidia and sclerotia was also reduced when lipA gene was deleted. ...
LipA coding lipoic acid synthetase was knocked out using homologous recombination. ...The growth was suppressed in lipA. The f …
A Novel Variant in the LIPA Gene Associated with Distinct Phenotype.
Sarajlija A, Armengol L, Maver A, Kitic I, Prokic D, Cehic M, Djuricic MS, Peterlin B. Sarajlija A, et al. Balkan J Med Genet. 2023 Mar 1;25(1):93-100. doi: 10.2478/bjmg-2022-0010. eCollection 2022 Jun. Balkan J Med Genet. 2023. PMID: 36880034 Free PMC article.
Deficiency of lysosomal acid lipase (LAL-D) is caused by biallelic pathogenic variants in the LIPA gene. Spectrum of LAL-D ranges from early onset of hepatosplenomegaly and psychomotor regression (Wolman disease) to a more chronic course (cholesteryl ester storage disease …
Deficiency of lysosomal acid lipase (LAL-D) is caused by biallelic pathogenic variants in the LIPA gene. Spectrum of LAL-D ranges fro …
ArgR directly inhibits lipA transcription in Pseudomonas protegens Pf-5.
Ying W, Wang XL, Shi HQ, Yan LW, Zhang BH, Li HQ, Yang JY, Zha DM. Ying W, et al. Biochimie. 2019 Dec;167:34-41. doi: 10.1016/j.biochi.2019.08.018. Epub 2019 Sep 3. Biochimie. 2019. PMID: 31491441
The results demonstrated that ArgR inhibits lipA expression at the transcriptional level. Further results showed that the inhibition of lipA transcription by ArgR is mediated by binding to the ArgR binding site of lipA promoter to produce steric hindrance, in …
The results demonstrated that ArgR inhibits lipA expression at the transcriptional level. Further results showed that the inhibition …
Functional Characterization of LIPA (Lysosomal Acid Lipase) Variants Associated With Coronary Artery Disease.
Evans TD, Zhang X, Clark RE, Alisio A, Song E, Zhang H, Reilly MP, Stitziel NO, Razani B. Evans TD, et al. Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2480-2491. doi: 10.1161/ATVBAHA.119.313443. Epub 2019 Oct 24. Arterioscler Thromb Vasc Biol. 2019. PMID: 31645127 Free PMC article.
We sought to functionally investigate the net impact of this locus on LIPA and whether rs1051338 could disrupt LIPA processing and function to explain coronary artery disease risk. ...CONCLUSIONS: Our findings show that common LIPA exonic variants in the sign …
We sought to functionally investigate the net impact of this locus on LIPA and whether rs1051338 could disrupt LIPA processing …
Therapeutic efficacy of rscAAVrh74.miniCMV.LIPA gene therapy in a mouse model of lysosomal acid lipase deficiency.
Lam P, Ashbrook A, Zygmunt DA, Yan C, Du H, Martin PT. Lam P, et al. Mol Ther Methods Clin Dev. 2022 Aug 4;26:413-426. doi: 10.1016/j.omtm.2022.08.001. eCollection 2022 Sep 8. Mol Ther Methods Clin Dev. 2022. PMID: 36092360 Free PMC article.
Recent clinical studies have shown efficacy of enzyme replacement therapy for both forms of LAL-D; however, no gene therapy approach has yet been developed for clinical use. Here, we show that rscAAVrh74.miniCMV.LIPA gene therapy can significantly improve disease symptoms …
Recent clinical studies have shown efficacy of enzyme replacement therapy for both forms of LAL-D; however, no gene therapy approach has yet …
2,178 results

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