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2011 | 1 |
2016 | 1 |
2020 | 1 |
2024 | 0 |
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Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors.
Methods. 2016 Oct 1;108:130-41. doi: 10.1016/j.ymeth.2016.04.007. Epub 2016 Apr 7.
Methods. 2016.
PMID: 27064001
Free PMC article.
Review.
These procedures were used in the discovery of biologically active compounds that inhibited the DNA unwinding function catalyzed by the human WRN helicase-nuclease defective in the premature aging disorder Werner syndrome. We describe in vitro and in v …
These procedures were used in the discovery of biologically active compounds that inhibited the DNA unwinding function catalyzed by the huma …
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.
Aggarwal M, Sommers JA, Shoemaker RH, Brosh RM Jr.
Aggarwal M, et al.
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. doi: 10.1073/pnas.1006423108. Epub 2011 Jan 10.
Proc Natl Acad Sci U S A. 2011.
PMID: 21220316
Free PMC article.
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was used to identify molecules that modulate DNA unwinding by Werner syndrome helicase (WRN), mutated in the premature …
Modulation of DNA repair proteins by small molecules has attracted great interest. An in vitro helicase activity screen was us …
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Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans.
Yang X, Zhang M, Dai Y, Sun Y, Aman Y, Xu Y, Yu P, Zheng Y, Yang J, Zhu X.
Yang X, et al.
Aging (Albany NY). 2020 Sep 9;12(17):16852-16866. doi: 10.18632/aging.103578. Epub 2020 Sep 9.
Aging (Albany NY). 2020.
PMID: 32902411
Free PMC article.
Currently there is no cure for AD and PD, and the development of novel drug candidates is demanding. Spermidine is a small anti-aging molecule with elimination of damaged mitochondria via the process of mitophagy identified as a molecular mechanism of action. …
Currently there is no cure for AD and PD, and the development of novel drug candidates is demanding. Spermidine is a small anti-ag …
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