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Arch Pediatr Adolesc Med. 2012 Apr;166(4):350-5. doi: 10.1001/archpediatrics.2011.1501. Epub 2012 Jan 2.

Hospitalizations for intussusception before and after the reintroduction of rotavirus vaccine in the United States.

Author information

  • 1Department of Pediatrics, University of Michigan, 300 N Ingalls, Ann Arbor, MI 48109, USA. josephzi@umich.edu

Abstract

OBJECTIVE:

To determine whether hospital discharges for intussusception in children younger than 1 year have changed since the reintroduction of rotavirus vaccine in the United States.

DESIGN:

Serial cross-sectional analysis.

SETTING:

US hospitals.

PARTICIPANTS:

Children younger than 1 year with a discharge diagnosis of intussusception identified in the Kids' Inpatient Database, a series of nationally representative data sets of pediatric hospital discharges in the United States with 4 available years prior to vaccine reintroduction (1997, 2000, 2003, and 2006) and 1 year after (2009).

MAIN EXPOSURES:

Hospital discharge before vs after rotavirus vaccine reintroduction.

OUTCOME MEASURES:

Total number and rate of hospital discharges for infants younger than 1 year with a diagnosis of intussusception (International Classification of Diseases, Ninth Revision, Clinical Modification code 560.0).

RESULTS:

From 1997 to 2006, there was no change in the total number of hospital discharges for intussusception, with a small decrease in the rate of intussusception discharges (41.6 [95% CI, 36.7-46.5] to 36.5 [95% CI, 31.7-41.2] per 100,000 infants). Based on the trend, the predicted rate of discharges for intussusception in 2009 was 36.0 (95% CI, 30.2-41.8) per 100,000 infants. The measured rate of hospital discharges for intussusception in 2009 was 33.3 (95% CI, 29.0-37.6) per 100,000 infants.

CONCLUSION:

The reintroduction of rotavirus vaccine since 2006 has not resulted in a detectable increase in the number of hospital discharges for intussusception among US infants.

PMID:
22213609
[PubMed - indexed for MEDLINE]
PMCID:
PMC3442774
Free PMC Article
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