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Nat Rev Immunol. 2011 Jul 15;11(8):551-8. doi: 10.1038/nri3020.

Interrogating the repertoire: broadening the scope of peptide-MHC multimer analysis.

Author information

  • 1Department of Microbiology and Immunology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA. mmdavis@stanford.edu

Abstract

Labelling antigen-specific T cells with peptide-MHC multimers has provided an invaluable way to monitor T cell-mediated immune responses. A number of recent developments in this technology have made these multimers much easier to make and use in large numbers. Furthermore, enrichment techniques have provided a greatly increased sensitivity that allows the analysis of the naive T cell repertoire directly. Thus, we can expect a flood of new information to emerge in the coming years.

PMID:
21760610
[PubMed - indexed for MEDLINE]
PMCID:
PMC3699324
Free PMC Article

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