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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 7
2001 6
2002 8
2003 8
2004 8
2005 5
2006 5
2007 5
2008 2
2009 8
2010 2
2011 6
2012 7
2013 3
2014 4
2015 5
2016 8
2017 11
2018 7
2019 8
2020 5
2021 6
2022 10
2023 5
2024 3

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141 results

Results by year

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Page 1
Non-alcoholic fatty liver disease (NAFLD): a review of pathophysiology, clinical management and effects of weight loss.
Pouwels S, Sakran N, Graham Y, Leal A, Pintar T, Yang W, Kassir R, Singhal R, Mahawar K, Ramnarain D. Pouwels S, et al. BMC Endocr Disord. 2022 Mar 14;22(1):63. doi: 10.1186/s12902-022-00980-1. BMC Endocr Disord. 2022. PMID: 35287643 Free PMC article. Review.
NAFLD is the most common chronic liver disease in the Western world. NAFLD is closely associated with metabolic disorders, including central obesity, dyslipidaemia, hypertension, hyperglycaemia and persistent abnormalities of liver function tests.In general NAFLD is …
NAFLD is the most common chronic liver disease in the Western world. NAFLD is closely associated with metabolic disorders, including …
Pathogenesis and treatment of non-alcoholic steatohepatitis and its fibrosis.
Lee KC, Wu PS, Lin HC. Lee KC, et al. Clin Mol Hepatol. 2023 Jan;29(1):77-98. doi: 10.3350/cmh.2022.0237. Epub 2022 Oct 13. Clin Mol Hepatol. 2023. PMID: 36226471 Free PMC article. Review.
Lipotoxicity, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress would further contribute to hepatocyte injury and death, leading to inflammation and immune dysfunction in the liver. During the healing process, the accumulation of an exces …
Lipotoxicity, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress would further contribute to hepatocyte injury …
AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK. Long MT, et al. Gastroenterology. 2022 Sep;163(3):764-774.e1. doi: 10.1053/j.gastro.2022.06.023. Epub 2022 Jul 14. Gastroenterology. 2022. PMID: 35842345 Free PMC article.
DESCRIPTION: Nonalcoholic fatty liver disease (NAFLD) is well recognized as a leading etiology for chronic liver disease, affecting >25% of the US and global populations. ...BEST PRACTICE ADVICE 8: Current evidence is inadequate to support routine testing for gen …
DESCRIPTION: Nonalcoholic fatty liver disease (NAFLD) is well recognized as a leading etiology for chronic liver disease, affe …
Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages☆.
Lefere S, Puengel T, Hundertmark J, Penners C, Frank AK, Guillot A, de Muynck K, Heymann F, Adarbes V, Defrêne E, Estivalet C, Geerts A, Devisscher L, Wettstein G, Tacke F. Lefere S, et al. J Hepatol. 2020 Oct;73(4):757-770. doi: 10.1016/j.jhep.2020.04.025. Epub 2020 Apr 29. J Hepatol. 2020. PMID: 32360434
Acute liver injury was induced by carbon tetrachloride (CCl(4)). The role of PPARs on macrophage functionality was studied in isolated hepatic macrophages, bone marrow-derived macrophages stimulated with palmitic acid, and circulating monocytes from patients with NA …
Acute liver injury was induced by carbon tetrachloride (CCl(4)). The role of PPARs on macrophage functionality was studied in …
Thiazolidinediones.
[No authors listed] [No authors listed] 2018 Jun 6. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2018 Jun 6. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643709 Free Books & Documents. Review.
Troglitazone was the first thiazolidinedione that received approval for use in the United States (January 1997). However, within a year of its approval, reports of severe liver injury and deaths from acute liver failure began to appear. Cautionary statements …
Troglitazone was the first thiazolidinedione that received approval for use in the United States (January 1997). However, within a year of i …
Thiazolidinedione safety.
Kung J, Henry RR. Kung J, et al. Expert Opin Drug Saf. 2012 Jul;11(4):565-79. doi: 10.1517/14740338.2012.691963. Epub 2012 May 22. Expert Opin Drug Saf. 2012. PMID: 22616948 Review.
AREAS COVERED: This review provides a comprehensive overview of the literature from 2000 onward reporting the known side effects of rosiglitazone and pioglitazone, with commentary on the quality of the data available, putative mechanism of each side effect and clinical sig …
AREAS COVERED: This review provides a comprehensive overview of the literature from 2000 onward reporting the known side effects of rosiglit …
Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.
Lo C, Toyama T, Wang Y, Lin J, Hirakawa Y, Jun M, Cass A, Hawley CM, Pilmore H, Badve SV, Perkovic V, Zoungas S. Lo C, et al. Cochrane Database Syst Rev. 2018 Sep 24;9(9):CD011798. doi: 10.1002/14651858.CD011798.pub2. Cochrane Database Syst Rev. 2018. PMID: 30246878 Free PMC article. Review.
In addition, 2 studies compared sitagliptin to glipizide; and 1 study compared each of sitagliptin to insulin, glitazars to pioglitazone, vildagliptin to sitagliptin, linagliptin to voglibose, and albiglutide to sitagliptin. ...SGLT2 inhibitors may have little or no effect …
In addition, 2 studies compared sitagliptin to glipizide; and 1 study compared each of sitagliptin to insulin, glitazars to pioglitazone …
Pioglitazone.
[No authors listed] [No authors listed] 2018 Jun 6. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2018 Jun 6. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643649 Free Books & Documents. Review.
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury....
Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglit …
PPAR gamma agonist, pioglitazone, rescues liver damage induced by renal ischemia/reperfusion injury.
Elshazly S, Soliman E. Elshazly S, et al. Toxicol Appl Pharmacol. 2019 Jan 1;362:86-94. doi: 10.1016/j.taap.2018.10.022. Epub 2018 Oct 26. Toxicol Appl Pharmacol. 2019. PMID: 30393147
Renal IR increased renal, hepatic and serum levels of tumor necrosis factor-alpha (TNF-alpha) and induced apoptotic cell death in liver. These effects were diminished with pioglitazone. In addition, pioglitazone reduced renal IR-induced oxidative stress in …
Renal IR increased renal, hepatic and serum levels of tumor necrosis factor-alpha (TNF-alpha) and induced apoptotic cell death in liver …
Pioglitazone attenuates tamoxifen-induced liver damage in rats via modulating Keap1/Nrf2/HO-1 and SIRT1/Notch1 signaling pathways: In-vivo investigations, and molecular docking analysis.
Kamel GAM, Elariny HA. Kamel GAM, et al. Mol Biol Rep. 2023 Dec;50(12):10219-10233. doi: 10.1007/s11033-023-08847-x. Epub 2023 Nov 7. Mol Biol Rep. 2023. PMID: 37934372 Free PMC article.
Pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is utilized to treat diabetes mellitus type-2. ...A schematic diagram illustrating the protective effect of PIO against TAM hepatotoxicity. PIO prevented TAM-induced liver …
Pioglitazone (PIO), a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is utilized to treat diabetes mellitus t …
141 results