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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1866 1
1872 1
1875 1
1885 1
1889 1
1891 5
1893 1
1899 1
1926 1
1928 2
1936 1
1947 1
1950 2
1951 1
1954 2
1956 2
1957 3
1959 1
1960 1
1961 2
1963 1
1964 2
1965 1
1966 2
1967 2
1968 3
1969 1
1970 1
1971 3
1972 2
1973 2
1974 2
1975 7
1976 8
1977 8
1978 12
1979 20
1980 19
1981 14
1982 21
1983 43
1984 79
1985 97
1986 137
1987 136
1988 178
1989 219
1990 292
1991 345
1992 410
1993 461
1994 486
1995 589
1996 617
1997 651
1998 696
1999 719
2000 757
2001 765
2002 814
2003 790
2004 828
2005 850
2006 903
2007 946
2008 1002
2009 958
2010 976
2011 987
2012 1053
2013 1074
2014 1099
2015 1119
2016 1139
2017 1047
2018 1124
2019 1107
2020 1279
2021 1271
2022 1192
2023 1179
2024 475

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28,560 results

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Page 1
Immortality of cell lines: challenges and advantages of establishment.
Maqsood MI, Matin MM, Bahrami AR, Ghasroldasht MM. Maqsood MI, et al. Cell Biol Int. 2013 Oct;37(10):1038-45. doi: 10.1002/cbin.10137. Epub 2013 Jun 24. Cell Biol Int. 2013. PMID: 23723166 Review.
Meanwhile, discovering the exact mechanisms of immortality, a major challenge for science yet, is believed to open new gateways toward understanding and treatment of cancer in the long term. This review summarises the methods involved in establishing immortality, it …
Meanwhile, discovering the exact mechanisms of immortality, a major challenge for science yet, is believed to open new gateways towar …
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.
Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE. Boukamp P, et al. J Cell Biol. 1988 Mar;106(3):761-71. doi: 10.1083/jcb.106.3.761. J Cell Biol. 1988. PMID: 2450098 Free PMC article.
In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but has resulted in cell lines with altered differentiation. We have established a spontaneously transformed human epit …
In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has b …
Cellular senescence, rejuvenation and potential immortality.
Sheldrake AR. Sheldrake AR. Proc Biol Sci. 2022 Mar 9;289(1970):20212434. doi: 10.1098/rspb.2021.2434. Epub 2022 Mar 2. Proc Biol Sci. 2022. PMID: 35232226 Free PMC article. Review.
The universal senescence paradigm sees senescence as inevitable in all cells. Damage accumulates. The potential immortality paradigm sees some cells as potentially immortal, especially unicellular organisms, germ cells and cancerous cells. ...If so, our understandin …
The universal senescence paradigm sees senescence as inevitable in all cells. Damage accumulates. The potential immortality paradigm …
Immortalizing Cells for Human Consumption.
Soice E, Johnston J. Soice E, et al. Int J Mol Sci. 2021 Oct 28;22(21):11660. doi: 10.3390/ijms222111660. Int J Mol Sci. 2021. PMID: 34769088 Free PMC article. Review.
Immortal cell lines have a long and complicated story, from the first recognized immortal human cell lines taken from Henrietta Lacks, to today, where they are used to assay toxicity and produce therapeutics, to the future, where they could be used to create meat wi …
Immortal cell lines have a long and complicated story, from the first recognized immortal human cell lines taken from Henriett …
Testicular cell lines.
Rahman NA, Huhtaniemi IT. Rahman NA, et al. Mol Cell Endocrinol. 2004 Dec 30;228(1-2):53-65. doi: 10.1016/j.mce.2003.05.001. Mol Cell Endocrinol. 2004. PMID: 15541572 Review.
The range of in vivo or in vitro immortalized cell lines currently available provides a variety of model systems for studies of normal and pathological cell functions. ...The TG techniques also enable the production of cell lines with specific characteristics, through inse …
The range of in vivo or in vitro immortalized cell lines currently available provides a variety of model systems for studies of norma …
Homologous plasmid recombination is elevated in immortally transformed cells.
Finn GK, Kurz BW, Cheng RZ, Shmookler Reis RJ. Finn GK, et al. Mol Cell Biol. 1989 Sep;9(9):4009-17. doi: 10.1128/mcb.9.9.4009-4017.1989. Mol Cell Biol. 1989. PMID: 2550810 Free PMC article.
The levels of intramolecular plasmid recombination, following transfection of a plasmid substrate for homologous recombination into normal and immortally transformed cells, have been examined by two independent assays. ...Such events, yielding predominantly deletions betwe …
The levels of intramolecular plasmid recombination, following transfection of a plasmid substrate for homologous recombination into normal a …
Accumulation and altered localization of telomere-associated protein TRF2 in immortally transformed and tumor-derived human breast cells.
Nijjar T, Bassett E, Garbe J, Takenaka Y, Stampfer MR, Gilley D, Yaswen P. Nijjar T, et al. Oncogene. 2005 May 5;24(20):3369-76. doi: 10.1038/sj.onc.1208482. Oncogene. 2005. PMID: 15735711
Upregulation of TRF2 protein was apparently due to differences in post-transcriptional regulation, as mRNA levels remained comparable in finite lifespan and immortal HMEC. TRF2 protein was not upregulated by the oncogenic agents alone in the absence of immortalization …
Upregulation of TRF2 protein was apparently due to differences in post-transcriptional regulation, as mRNA levels remained comparable in fin …
Chapitre 5. Killing Immortals.
Tammi M. Tammi M. J Int Bioethique Ethique Sci. 2020;30(4):119-127. doi: 10.3917/jibes.304.0119. J Int Bioethique Ethique Sci. 2020. PMID: 35723987
The problem with the organisms hydra, small fresh-water polyps (Hydra viridissima and Hydra littoralis) is that they are biologically immortal. They seem to never age. Their natural life span is, assuming they live in perfect conditions, eternal.However, while a hydra does …
The problem with the organisms hydra, small fresh-water polyps (Hydra viridissima and Hydra littoralis) is that they are biologically imm …
Immortal ethics.
Harris J. Harris J. Ann N Y Acad Sci. 2004 Jun;1019:527-34. doi: 10.1196/annals.1297.098. Ann N Y Acad Sci. 2004. PMID: 15247080
This article draws on ideas published in my "Intimations of Immortality" essay in Science (Vol. 288, No. 5463, p. 59, April 7, 2000) and my "Intimations of Immortality-The Ethics and Justice of Life Extending Therapies" in editor Michael Freeman's Current Legal Prob …
This article draws on ideas published in my "Intimations of Immortality" essay in Science (Vol. 288, No. 5463, p. 59, April 7, 2000) …
Telomerase, immortality and cancer.
Krupp G, Bonatz G, Parwaresch R. Krupp G, et al. Biotechnol Annu Rev. 2000;6:103-40. doi: 10.1016/s1387-2656(00)06020-8. Biotechnol Annu Rev. 2000. PMID: 11193292 Review.
In contrast to mammals, indeterminately growing multicellular organisms, like fish and crustaceae, maintain unlimited growth potential or 'immortality' in all somatic tissues throughout their entire life. Also this cell immortalization is brought about by maintainin …
In contrast to mammals, indeterminately growing multicellular organisms, like fish and crustaceae, maintain unlimited growth potential or ' …
28,560 results
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