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Dissolving microneedles for enhanced local delivery of capsaicin to rat skin tissue.
Ito Y, Kobuchi S, Inoue G, Kakumu E, Aoki M, Sakaeda T, Takada K. Ito Y, et al. J Drug Target. 2017 Jun;25(5):420-424. doi: 10.1080/1061186X.2016.1266650. Epub 2016 Dec 14. J Drug Target. 2017. PMID: 27918217
The pharmacological activity of capsaicin DMNs was compared to that of capsaicin cream as a positive control, by measuring the idiospasm of depilated rat skin. The time required to achieve 50% idiospasm suppression was 26.3 1.9 min and 53.0 2.3 min for low-dose and …
The pharmacological activity of capsaicin DMNs was compared to that of capsaicin cream as a positive control, by measuring the idiospasm …
Dissolving microneedles to obtain rapid local anesthetic effect of lidocaine at skin tissue.
Ito Y, Ohta J, Imada K, Akamatsu S, Tsuchida N, Inoue G, Inoue N, Takada K. Ito Y, et al. J Drug Target. 2013 Sep;21(8):770-5. doi: 10.3109/1061186X.2013.811510. Epub 2013 Jul 1. J Drug Target. 2013. PMID: 23808605
Pharmacological activity of DMs were compared to lidocaine cream by the suppression of idiospasm of hair-removed rat skin. Type 1, 2 and 3 DMs showed faster onset time, 5 min, than lidocaine cream. ...
Pharmacological activity of DMs were compared to lidocaine cream by the suppression of idiospasm of hair-removed rat skin. Type 1, 2 …