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Page 1
Showing results for isotype
Your search for icotype retrieved no results
Isotype selection for antibody-based cancer therapy.
Vukovic N, van Elsas A, Verbeek JS, Zaiss DMW. Vukovic N, et al. Clin Exp Immunol. 2021 Mar;203(3):351-365. doi: 10.1111/cei.13545. Epub 2020 Nov 30. Clin Exp Immunol. 2021. PMID: 33155272 Free PMC article. Review.
Thus, for many mAbs, Fc-mediated effector functions critically contribute to the efficacy of treatment. As immunoglobulin (Ig) isotypes differ in their ability to bind to Fc receptors on immune cells as well as in their ability to activate complement, they differ in …
Thus, for many mAbs, Fc-mediated effector functions critically contribute to the efficacy of treatment. As immunoglobulin (Ig) iso …
Isotype determination of antibodies.
Hornbeck P, Fleisher TA, Papadopoulos NM. Hornbeck P, et al. Curr Protoc Immunol. 2001 May;Chapter 2:Unit 2.2. doi: 10.1002/0471142735.im0202s01. Curr Protoc Immunol. 2001. PMID: 18432767 Review.
The immunologist's approach to such a problem is to consider the antibody or immunoglobulin molecules themselves as antigens and to use anti-immunoglobulin antibodies as the specific and sensitive agents of detection. ...
The immunologist's approach to such a problem is to consider the antibody or immunoglobulin molecules themselves as antigens and to u …
Antibody Isotype Switching in Vertebrates.
Senger K, Hackney J, Payandeh J, Zarrin AA. Senger K, et al. Results Probl Cell Differ. 2015;57:295-324. doi: 10.1007/978-3-319-20819-0_13. Results Probl Cell Differ. 2015. PMID: 26537387 Review.
The humoral or antibody-mediated immune response in vertebrates has evolved to respond to diverse antigenic challenges in various anatomical locations. Diversification of the immunoglobulin heavy chain (IgH) constant region via isotype switching allows for remarkabl …
The humoral or antibody-mediated immune response in vertebrates has evolved to respond to diverse antigenic challenges in various anatomical …
Isotype Specific Assembly of B Cell Antigen Receptors and Synergism With Chemokine Receptor CXCR4.
Maity PC, Datta M, Nicolò A, Jumaa H. Maity PC, et al. Front Immunol. 2018 Dec 18;9:2988. doi: 10.3389/fimmu.2018.02988. eCollection 2018. Front Immunol. 2018. PMID: 30619343 Free PMC article. Review.
Among five known isotypes, IgM and IgD are the common B cell antigen receptors (BCRs) that are co-expressed in naive B cells. ...Interestingly, the cytoskeleton network beneath the membrane controls the BCR isotype-specific organization and its interaction with co-r …
Among five known isotypes, IgM and IgD are the common B cell antigen receptors (BCRs) that are co-expressed in naive B cells. ...Inte …
Isotype control of B cell signaling.
Silver K, Cornall RJ. Silver K, et al. Sci STKE. 2003 May 27;2003(184):pe21. doi: 10.1126/stke.2003.184.pe21. Sci STKE. 2003. PMID: 12771436 Review.
The B cell receptor (BCR) consists of an antigen-binding membrane immunoglobulin (mIg) associated with the CD79alpha and CD79beta heterodimer. ...After antigenic stimulation, B cells undergo isotype switching to yield IgG, IgE, or IgA. Recent research suggests that …
The B cell receptor (BCR) consists of an antigen-binding membrane immunoglobulin (mIg) associated with the CD79alpha and CD79beta het …
Influence of immunoglobulin isotype on therapeutic antibody function.
Beers SA, Glennie MJ, White AL. Beers SA, et al. Blood. 2016 Mar 3;127(9):1097-101. doi: 10.1182/blood-2015-09-625343. Epub 2016 Jan 13. Blood. 2016. PMID: 26764357 Free PMC article. Review.
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is essential to improve outcome. It has become clear over recent years that isotype choice is vital to therapeutic success with agents that …
Monoclonal antibody (mAb) therapeutics are revolutionizing cancer treatment; however, not all tumors respond, and agent optimization is esse …
The role of BCR isotype in B-cell development and activation.
Surova E, Jumaa H. Surova E, et al. Adv Immunol. 2014;123:101-39. doi: 10.1016/B978-0-12-800266-7.00003-0. Adv Immunol. 2014. PMID: 24840949 Review.
In this chapter, we summarize and discuss the accumulated knowledge on the role of the mu, delta, and gamma HC isotypes of the conventional and precursor BCR in B-cell differentiation, selection, and engagement with (auto)antigens....
In this chapter, we summarize and discuss the accumulated knowledge on the role of the mu, delta, and gamma HC isotypes of the conven …
Regulation of isotype switching.
Vercelli D, Geha RS. Vercelli D, et al. Curr Opin Immunol. 1992 Dec;4(6):794-7. doi: 10.1016/0952-7915(92)90064-l. Curr Opin Immunol. 1992. PMID: 1466804 Review.
In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of germ line transcription by isotype-specific cytokines is emerging as a crucial mechanism for increasing the accessibility of a particula …
In the past year, our understanding of the mechanisms that regulate isotype switching has significantly progressed. Activation of ger …
Isotype Determination of Antibodies.
Hornbeck P, Fleisher TA, Papadopoulos NM. Hornbeck P, et al. Curr Protoc Immunol. 2017 Feb 2;116:2.2.1-2.2.7. doi: 10.1002/cpim.19. Curr Protoc Immunol. 2017. PMID: 28150862
The serological class of the protein is determined by the structure of the antibody constant region. Several methods of class or isotype determination are outlined in this unit: sandwich ELISA, electrophoresis, and immunofixation, or use of a variety of commercially availa …
The serological class of the protein is determined by the structure of the antibody constant region. Several methods of class or isotype …
Isotype switching in CD5 B cells.
Whitmore AC, Haughton G, Arnold LW. Whitmore AC, et al. Ann N Y Acad Sci. 1992 May 4;651:143-51. doi: 10.1111/j.1749-6632.1992.tb24603.x. Ann N Y Acad Sci. 1992. PMID: 1376029 Review. No abstract available.
256,892 results
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