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1953 2
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1980 2
1984 1
1985 3
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1987 5
1988 1
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1993 13
1994 14
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1996 17
1997 7
1998 13
1999 20
2000 18
2001 13
2002 15
2003 25
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2007 15
2008 17
2009 16
2010 21
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2012 22
2013 8
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2015 14
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442 results

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Page 1
Hygromycin A in the Lymelight.
Arnaboldi PM, Narasimhan S. Arnaboldi PM, et al. Cell Host Microbe. 2021 Nov 10;29(11):1599-1601. doi: 10.1016/j.chom.2021.10.007. Cell Host Microbe. 2021. PMID: 34762823 Free article.
In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten antibiotic, Hygromycin A, as a spirochete-specific antibacterial that is conducive to gut health....
In a recent paper in Cell, Leimer et al. demonstrate the utility of a long-forgotten antibiotic, Hygromycin A, as a spirochete …
A selective antibiotic for Lyme disease.
Leimer N, Wu X, Imai Y, Morrissette M, Pitt N, Favre-Godal Q, Iinishi A, Jain S, Caboni M, Leus IV, Bonifay V, Niles S, Bargabos R, Ghiglieri M, Corsetti R, Krumpoch M, Fox G, Son S, Klepacki D, Polikanov YS, Freliech CA, McCarthy JE, Edmondson DG, Norris SJ, D'Onofrio A, Hu LT, Zgurskaya HI, Lewis K. Leimer N, et al. Cell. 2021 Oct 14;184(21):5405-5418.e16. doi: 10.1016/j.cell.2021.09.011. Epub 2021 Oct 6. Cell. 2021. PMID: 34619078 Free PMC article.
Hygromycin A targets the ribosomes and is taken up by B. burgdorferi, explaining its selectivity. Hygromycin A cleared the B. burgdorferi infection in mice, including animals that ingested the compound in a bait, and was less disruptive to the fecal mi …
Hygromycin A targets the ribosomes and is taken up by B. burgdorferi, explaining its selectivity. Hygromycin A c …
Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis.
Ding X, Yuan T, Chen W, Wang X, Chu Y, Liu X, Hu Y, Hu L. Ding X, et al. J Antibiot (Tokyo). 2022 Mar;75(3):176-180. doi: 10.1038/s41429-022-00506-w. Epub 2022 Jan 21. J Antibiot (Tokyo). 2022. PMID: 35064242
On the basis of the one strain-many compounds (OSMAC) strategy, two new hygromycin A derivatives (3, 4), together with six known compounds were isolated from a medicinal plant inter rhizospheric Streptomyces in Pulsatilla chinensis. ...
On the basis of the one strain-many compounds (OSMAC) strategy, two new hygromycin A derivatives (3, 4), together with six kno …
Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A.
Chen CW, Leimer N, Syroegin EA, Dunand C, Bulman ZP, Lewis K, Polikanov YS, Svetlov MS. Chen CW, et al. Nat Commun. 2023 Jul 14;14(1):4196. doi: 10.1038/s41467-023-39653-5. Nat Commun. 2023. PMID: 37452045 Free PMC article.
Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and drug-resistant bacteria, only a few known drug pairs exhibit synergy/cooperativity in killing bacteria. Here, we discover that well-known ribos …
Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and dru …
Hygromycin A, a novel inhibitor of ribosomal peptidyltransferase.
Guerrero MD, Modolell J. Guerrero MD, et al. Eur J Biochem. 1980 Jun;107(2):409-14. doi: 10.1111/j.1432-1033.1980.tb06044.x. Eur J Biochem. 1980. PMID: 6156832 Free article.
The action of hygromycin A on peptidyl transfer is similar to that of chloramphenicol, an antibiotic that shares some common structural features with hygromycin A. ...Hygromycin A is a more potent agent than chloramphenicol and binds quit …
The action of hygromycin A on peptidyl transfer is similar to that of chloramphenicol, an antibiotic that shares some common s …
A myo-inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A.
Akintubosun MO, Higgins MA. Akintubosun MO, et al. Beilstein J Org Chem. 2024 Mar 14;20:589-596. doi: 10.3762/bjoc.20.51. eCollection 2024. Beilstein J Org Chem. 2024. PMID: 38505238 Free PMC article.
Hygromycin A is a broad-spectrum antibiotic that contains a furanose, cinnamic acid, and aminocyclitol moieties. ...
Hygromycin A is a broad-spectrum antibiotic that contains a furanose, cinnamic acid, and aminocyclitol moieties. ...
Biosynthetic origin of hygromycin A.
Habib el-SE, Scarsdale JN, Reynolds KA. Habib el-SE, et al. Antimicrob Agents Chemother. 2003 Jul;47(7):2065-71. doi: 10.1128/AAC.47.7.2065-2071.2003. Antimicrob Agents Chemother. 2003. PMID: 12821448 Free PMC article.
Hygromycin A, an antibiotic produced by Streptomyces hygroscopicus, is an inhibitor of bacterial ribosomal peptidyl transferase. ...Incorporation of [carboxy-(13)C]-4-hydroxybenzoic acid and intact incorporation of [2,3-(13)C(2)]propionate are consistent with a poly …
Hygromycin A, an antibiotic produced by Streptomyces hygroscopicus, is an inhibitor of bacterial ribosomal peptidyl transferas …
Production of hygromycin A analogs in Streptomyces hygroscopicus NRRL 2388 through identification and manipulation of the biosynthetic gene cluster.
Palaniappan N, Ayers S, Gupta S, Habib el-S, Reynolds KA. Palaniappan N, et al. Chem Biol. 2006 Jul;13(7):753-64. doi: 10.1016/j.chembiol.2006.05.013. Chem Biol. 2006. PMID: 16873023
A 31.5 kb genomic DNA region covering the hygromycin A biosynthetic gene cluster has been identified, cloned, and sequenced. The hygromycin gene cluster has 29 ORFs which can be assigned to hygromycin A resistance as well as regulation and biosynthesis …
A 31.5 kb genomic DNA region covering the hygromycin A biosynthetic gene cluster has been identified, cloned, and sequenced. T …
442 results