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Evaluation of tests of hypothalamic-pituitary-adrenal axis function used to measure effects of inhaled corticosteroids.
Bernstein DI, Allen DB. Bernstein DI, et al. Ann Allergy Asthma Immunol. 2007 Feb;98(2):118-27. doi: 10.1016/S1081-1206(10)60683-7. Ann Allergy Asthma Immunol. 2007. PMID: 17304877 Review.
OBJECTIVES: To review the evidence supporting the evaluation of hypothalamic-pituitary-adrenal (HPA) axis function as a measure of systemic exposure and clinical adverse events, discuss factors that affect systemic exposure to inhaled cor …
OBJECTIVES: To review the evidence supporting the evaluation of hypothalamic-pituitary-adrenal (HPA) axis fun …
Hypothalamic-Pituitary-Adrenal Activity in Adverse Events Reporting After Placebo Administration.
Benedetti F, Amanzio M, Giovannelli F, Craigs-Brackhahn K, Shaibani A. Benedetti F, et al. Clin Pharmacol Ther. 2021 Nov;110(5):1349-1357. doi: 10.1002/cpt.2388. Epub 2021 Aug 23. Clin Pharmacol Ther. 2021. PMID: 34365636
Here, we studied 192 healthy subjects who received placebo oxygen through a mask after reading (READ) or not reading (NO-READ) a list of possible adverse events of oxygen breathing: headache, chest pain, abdominal pain, and cough. The whole hypothalamus-pituitary-adrenal axis …
Here, we studied 192 healthy subjects who received placebo oxygen through a mask after reading (READ) or not reading (NO-READ) a list of pos …
Effect of Long-term Inhaled Corticosteroids on the Hypothalamic-Pituitary-Adrenal Axis in Children with Asthma.
Hema LS, Kumar P, Goyal JP, Vyas V, Singh K. Hema LS, et al. Indian J Pediatr. 2024 May;91(5):441-447. doi: 10.1007/s12098-023-04706-6. Epub 2023 Jul 7. Indian J Pediatr. 2024. PMID: 37418102
OBJECTIVES: To assess the effect of the long-term use of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrenal (HPA) axis. METHODS: Children (5-18 y) diagnosed with asthma and on ICS therapy for 6 mo were included. ...Post-ACTH stimulatio …
OBJECTIVES: To assess the effect of the long-term use of inhaled corticosteroids (ICS) on the hypothalamic-pituitary-adrena …
Suppression of hypothalamic-pituitary-adrenal axis activity with inhaled flunisolide and fluticasone propionate in adult asthma patients.
Casale TB, Nelson HS, Stricker WE, Raff H, Newman KB. Casale TB, et al. Ann Allergy Asthma Immunol. 2001 Nov;87(5):379-85. doi: 10.1016/S1081-1206(10)62918-3. Ann Allergy Asthma Immunol. 2001. PMID: 11730179 Clinical Trial.
BACKGROUND: Suppression of the hypothalamic-pituitary-adrenal (HPA) axis, a potential systemic effect of inhaled corticosteroid therapy, can be quantified by monitoring serum, urinary, and salivary cortisol levels. OBJECTIVES: 1) Compare the effects on …
BACKGROUND: Suppression of the hypothalamic-pituitary-adrenal (HPA) axis, a potential systemic effect of inhaled …
Inhaled fluticasone furoate/vilanterol does not affect hypothalamic-pituitary-adrenal axis function in adolescent and adult asthma: randomised, double-blind, placebo-controlled study.
Allen A, Schenkenberger I, Trivedi R, Cole J, Hicks W, Gul N, Jacques L. Allen A, et al. Clin Respir J. 2013 Oct;7(4):397-406. doi: 10.1111/crj.12026. Epub 2013 Jun 5. Clin Respir J. 2013. PMID: 23578031 Free PMC article. Clinical Trial.
FF is in development as a once-daily treatment for asthma as monotherapy and in combination with vilanterol (VI), a long-acting beta2 agonist. Corticosteroids can have systemic effects on hypothalamic-pituitary-adrenal (HPA) axis function, poten …
FF is in development as a once-daily treatment for asthma as monotherapy and in combination with vilanterol (VI), a long-acting beta2 agonis …
Effects of fluticasone propionate, triamcinolone acetonide, prednisone, and placebo on the hypothalamic-pituitary-adrenal axis.
Li JT, Goldstein MF, Gross GN, Noonan MJ, Weisberg S, Edwards L, Reed KD, Rogenes PR. Li JT, et al. J Allergy Clin Immunol. 1999 Apr;103(4):622-9. doi: 10.1016/s0091-6749(99)70234-4. J Allergy Clin Immunol. 1999. PMID: 10200011 Clinical Trial.
BACKGROUND: Many clinicians are reluctant to prescribe inhaled corticosteroids because of concerns over potential effects on the hypothalamic-pituitary-adrenal axis. OBJECTIVE: The purpose of this study was to compare the adrenal responses to 6-hour co …
BACKGROUND: Many clinicians are reluctant to prescribe inhaled corticosteroids because of concerns over potential effects on the hypothal …
Hypothalamic-pituitary-adrenal axis function after inhaled corticosteroids: unreliability of urinary free cortisol estimation.
Fink RS, Pierre LN, Daley-Yates PT, Richards DH, Gibson A, Honour JW. Fink RS, et al. J Clin Endocrinol Metab. 2002 Oct;87(10):4541-6. doi: 10.1210/jc.2002-020287. J Clin Endocrinol Metab. 2002. PMID: 12364432 Clinical Trial.
Free cortisol in the urine (UFC) is frequently measured in clinical research to assess whether inhaled corticosteroids (ICS) cause suppression of the hypothalamic-pituitary-adrenal axis. Thirteen healthy male subjects received single inhaled dos …
Free cortisol in the urine (UFC) is frequently measured in clinical research to assess whether inhaled corticosteroids (ICS) cause su …
Copeptin response to panic provocation with CO2 in healthy adults.
Müller JC, Walter C, Leibold N, Wiedemann K, Kellner M, Demiralay C. Müller JC, et al. J Psychiatr Res. 2023 Sep;165:225-232. doi: 10.1016/j.jpsychires.2023.07.006. Epub 2023 Jul 22. J Psychiatr Res. 2023. PMID: 37517243
Additional to the psychological response, the physiological symptoms are an important aspect of the experienced panic. However, data on the extent of hypothalamic-pituitary-adrenal (HPA)-axis activation during panic attacks is inconsistent. ...During a …
Additional to the psychological response, the physiological symptoms are an important aspect of the experienced panic. However, data on the …
Hypothalamic-pituitary-adrenal axis effects of mometasone furoate/formoterol fumarate vs fluticasone propionate/salmeterol administered through metered-dose inhaler.
Kosoglou T, Hubbell J, Cutler DL, Johnson-Levonas AO, Xu D, Kantesaria BS, Kim K, Miller SD. Kosoglou T, et al. Chest. 2013 Dec;144(6):1795-1802. doi: 10.1378/chest.13-0505. Chest. 2013. PMID: 24077095 Clinical Trial.
BACKGROUND: The effects of mometasone furoate and fluticasone propionate on the hypothalamic-pituitary-adrenal axis were compared when administered from combination metered-dose inhaler (MDI) products. METHODS: In a randomized, open-label, placebo-cont …
BACKGROUND: The effects of mometasone furoate and fluticasone propionate on the hypothalamic-pituitary-adrenal axis …
Comparative clinical pharmacology of mometasone furoate, fluticasone propionate and fluticasone furoate.
Daley-Yates PT, Deans A, Mehta R, Sousa AR. Daley-Yates PT, et al. Pulm Pharmacol Ther. 2022 Dec;77:102171. doi: 10.1016/j.pupt.2022.102171. Epub 2022 Oct 13. Pulm Pharmacol Ther. 2022. PMID: 36243386 Clinical Trial.
AIMS: To investigate the pharmacokinetics and effects on the hypothalamic-pituitary-adrenal (HPA) axis of mometasone furoate (MF), fluticasone propionate (FP) and fluticasone furoate (FF). ...Study 3: Inhaled FP and FF had similar systemic bioavailabil …
AIMS: To investigate the pharmacokinetics and effects on the hypothalamic-pituitary-adrenal (HPA) axis of mometa …
43 results