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heterosynkaryon
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heterosyncaryon
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Horizontal transmission of malignancy: in-vivo fusion of human lymphomas with hamster stroma produces tumors retaining human genes and lymphoid pathology.
PLoS One. 2013;8(2):e55324. doi: 10.1371/journal.pone.0055324. Epub 2013 Feb 6.
PLoS One. 2013.
PMID: 23405135
Free PMC article.
We report the in-vivo fusion of two Hodgkin lymphomas with golden hamster cheek pouch cells, resulting in serially-transplanted (over 5-6 years) GW-532 and GW-584 heterosynkaryon tumor cells displaying both human and hamster DNA (by FISH), lymphoma-like morphology, aggress …
We report the in-vivo fusion of two Hodgkin lymphomas with golden hamster cheek pouch cells, resulting in serially-transplanted (over 5-6 ye …
Horizontal transmission and retention of malignancy, as well as functional human genes, after spontaneous fusion of human glioblastoma and hamster host cells in vivo.
Goldenberg DM, Zagzag D, Heselmeyer-Haddad KM, Berroa Garcia LY, Ried T, Loo M, Chang CH, Gold DV.
Goldenberg DM, et al.
Int J Cancer. 2012 Jul 1;131(1):49-58. doi: 10.1002/ijc.26327. Epub 2011 Aug 30.
Int J Cancer. 2012.
PMID: 21796629
Free PMC article.
Cell fusion in vitro has been used to study cancer, gene mapping and regulation, and the production of antibodies via hybridomas. However, in-vivo heterosynkaryon formation by cell-cell fusion has received less attention. ...
Cell fusion in vitro has been used to study cancer, gene mapping and regulation, and the production of antibodies via hybridomas. However, i …
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