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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated Histone acetylation.

Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA.

J Lipid Res. 2016 Mar 24. pii: jlr.M067447. [Epub ahead of print]


Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function.

Yi JK, Xu R, Jeong E, Mileva I, Truman JP, Lin CL, Wang K, Snider J, Wen S, Obeid LM, Hannun YA, Mao C.

Oncotarget. 2016 Mar 19. doi: 10.18632/oncotarget.8195. [Epub ahead of print]


Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.

Xu R, Wang K, Mileva I, Hannun YA, Obeid LM, Mao C.

Oncotarget. 2016 Mar 1. doi: 10.18632/oncotarget.7825. [Epub ahead of print]


CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles.

Carroll BL, Pulkoski-Gross MJ, Hannun YA, Obeid LM.

Oncotarget. 2016 Feb 22. doi: 10.18632/oncotarget.7566. [Epub ahead of print]


New role for ceramide in the pheromone response.

Matmati N, Kitagaki H, Hannun YA.

Cell Cycle. 2016 Mar 3;15(5):617-8. doi: 10.1080/15384101.2016.1143271. No abstract available.


Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast.

Chen PW, Fonseca LL, Hannun YA, Voit EO.

PLoS One. 2016 Jan 19;11(1):e0146839. doi: 10.1371/journal.pone.0146839. eCollection 2016.


Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ.

Biochem J. 2016 Mar 15;473(6):743-55. doi: 10.1042/BJ20150586. Epub 2016 Jan 8.


Substantial contribution of extrinsic risk factors to cancer development.

Wu S, Powers S, Zhu W, Hannun YA.

Nature. 2016 Jan 7;529(7584):43-7. doi: 10.1038/nature16166. Epub 2015 Dec 16.


Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.

Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C.

PLoS Genet. 2015 Oct 16;11(10):e1005591. doi: 10.1371/journal.pgen.1005591. eCollection 2015 Oct.


Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.

Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski J, Hicks WL, Krebs MP, Naggert J, Hannun YA, Dunn TM, Nishina PM.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12962-7. doi: 10.1073/pnas.1516733112. Epub 2015 Oct 5.


Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.

Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM.

J Biol Chem. 2015 Oct 16;290(42):25356-73. doi: 10.1074/jbc.M115.658658. Epub 2015 Aug 28.


Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.

Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid LM, Yaegashi N, Grabowski GA, Hannun YA.

PLoS One. 2015 Aug 27;10(8):e0136633. doi: 10.1371/journal.pone.0136633. eCollection 2015.


Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.

Casasampere M, Camacho L, Cingolani F, Casas J, Egido-Gabás M, Abad JL, Bedia C, Xu R, Wang K, Canals D, Hannun YA, Mao C, Fabrias G.

J Lipid Res. 2015 Oct;56(10):2019-28. doi: 10.1194/jlr.D061564. Epub 2015 Aug 18.


Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast.

Chen PW, Fonseca LL, Hannun YA, Voit EO.

PLoS Comput Biol. 2015 Aug 4;11(8):e1004373. doi: 10.1371/journal.pcbi.1004373. eCollection 2015 Aug.


Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM.

FASEB J. 2015 Nov;29(11):4654-69. doi: 10.1096/fj.15-274340. Epub 2015 Jul 24.


Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.

Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA.

Structure. 2015 Aug 4;23(8):1482-91. doi: 10.1016/j.str.2015.06.013. Epub 2015 Jul 16.


Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.

Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE.

PLoS One. 2015 Jul 13;10(7):e0133032. doi: 10.1371/journal.pone.0133032. eCollection 2015.


IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA.

PLoS One. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314. eCollection 2015.


A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.

Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM.

FASEB J. 2015 Jul;29(7):2803-13. doi: 10.1096/fj.15-270413. Epub 2015 Mar 24.

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